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MetabolomicsCancer-cell-secreted exosomal miR-105 promotes tumour growth through the Myc-dependent metabolic reprogramming of stromal cells
Cancer and other cells residing in the same niche engage various modes of interactions to synchronize and to buffer the negative effects of environmental changes. Extracellular miRNAs have been recently implicated in the intercellular crosstalk. Here we show a mechanistic model involving breast-canc...
2018-07-10 | MTBLS626 | MetaboLights
ProteomicsSILAC proteomic analysis of secreted proteins from PLC cells expressing EV or PRSS35
Since PRSS35 only exhibited tumor suppressive effects in mice, but not in the cultured cells, we speculated that some factors in the microenvironment are affected by PRSS35. To explore this possibility, we performed SILAC proteomic analysis in conjunction with RNA sequencing to identify secreted pro...
ORGANISM(S): Homo sapiens (Human) 
2023-02-15 | PXD033579 | Pride
Ev Prss35 Plc Secreted proteins 
TranscriptomicsExpression analysis of the Theileria parva subtelomere-encoded variable secreted protein gene family
The protozoan parasite Theileria parva infects and transforms bovine lymphocytes inducing uncontrolled proliferation. The transforming schizont resides free in the host cell cytoplasm and it is assumed that proteins released from the parasite contribute to host cell transformation and parasite pers...
ORGANISM(S): Theileria parva 
2010-05-15 | E-GEOD-14093 | biostudies-arrayexpress
TranscriptomicsDsbA plays a critical and multi-faceted role in the production of secreted virulence factors by Erwinia carotovora
Erwinia carotovora subsp. atroseptica (Eca) is an enterobacterial phytopathogen causing economically-significant soft rot disease. Pathogenesis is mediated by multiple secreted virulence factors, many of which are secreted by the Type II (Out) secretion system. DsbA catalyses the introduction of dis...
ORGANISM(S): Pectobacterium carotovorum 
2010-06-20 | E-GEOD-10647 | biostudies-arrayexpress
GenomicsMultiplex, multimodal mapping of variant functional effects in secreted proteins
Multiplex, multimodal mapping of variant functional effects in secreted proteins
PRJNA1014772 | ENA
TranscriptomicsGene expression profiling in the human pathogenic dermatophyte Trichophyton rubrum during growth on proteins
Dermatophytes are highly specialized filamentous fungi which cause the majority of superficial mycoses in humans and animals. The high secreted proteolytic activity of these microorganisms during growth on proteins is assumed to be linked with their particular ability to exclusively infect keratiniz...
ORGANISM(S): Trichophyton rubrum 
2008-12-30 | E-GEOD-11711 | biostudies-arrayexpress
GenomicsComprehensive understanding of identities and antigenicities of surface and secreted proteins in Toxoplasma gondii tachyzoites
Comprehensive understanding of identities and antigenicities of surface and secreted proteins in Toxoplasma gondii tachyzoites
PRJNA407885 | ENA
TranscriptomicsSecreted and membrane-associated genes
Large-scale identification of secreted and membrane-associated gene products using DNA microarrays. This study is described more fully in Diehn M et al.(2000) Nat Genet 25:58-62
ORGANISM(S): Homo sapiens 
2002-06-27 | E-GEOD-48 | biostudies-arrayexpress
GenomicsIsolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues
Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues
PRJNA892075 | ENA
TranscriptomicsGene expression in aerial hyphae in response to rep1 deletion in Ustilago maydis
The rep1 gene of the maize pathogen Ustilago maydis encodes a pre-pro-protein that is processed in the secretory pathway into 11 peptides. These so-called repellents form amphipathic amyloid fibrils at the surface of aerial hyphae. Strains in which the rep1 gene is inactivated (M-bM-^HM-^Frep1 strai...
ORGANISM(S): Ustilago maydis 
2011-05-01 | E-GEOD-21490 | biostudies-arrayexpress
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