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ProteomicsA SIRT7-dependent acetylation switch regulates early B-cell differentiation and lineage commitment through PAX5
B lymphopoiesis is a key developmental event orchestrated by a complex combinatorial action of lineage-specific transcription factors. In early B cell progenitors, lineage commitment is directly mediated by the master regulator PAX5, whose deficiency is commonly associated with B cell Acute Lymphobl...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-20 | PXD046457 | Pride
Sirtuins Sirt7 Acetylation Pax5 B cell progenitors Pre-b cell Hematopoiesis Immunoaffinity 
ProteomicsActivity of the novel BTK inhibitor TG-1701 is associated with the disruption of the Ikaros signaling pathway in responder B-NHL patients and with sensitization to anti-CD20 therapy in B-NHL xenografts
Covalent Bruton's tyrosine kinase inhibitors (BTKis) have transformed the treatment of B-cell non-Hodgkin lymphoma (B-NHL), including chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), but their activity has been limited by off-target toxicity and acquired drug resistance. TG-1701 is...
ORGANISM(S): Homo sapiens (Human) 
2021-09-22 | PXD023231 | Pride
Xenografts Tmt B-nhl Btk Maxquant Tg-1701 Phosphoproteomics Ikaros 
UnknownmiR-28-based combination therapy impairs aggressive B cell lymphoma growth by rewiring DNA replication.
Not available
S-EPMC10585006 | biostudies-literature
GenomicsDNA-seq of an ELMSeq reporter cassette to study impact of C-terminal sequence variations on protein abundance
A ELMSeq reporter cassette was created to monitor Dam levels by methylation, and introduced in the genome. The regions of 6 nt upstream and 6 nt downstream the stop codon were randomized to study their effect on gene expression. The ELMSeq reporter cassette was composed of: promoter - dam - random N...
ORGANISM(S): Mycoplasma pneumoniae 
2020-05-04 | E-MTAB-8223 | biostudies-arrayexpress
TranscriptomicsExpression data from MALD1 and MCL cases
Patients with conventional mantle cell lymphoma (MCL) show an aggressive clinical behavior. However, cases fulfilling the WHO criteria for MCL, but that remain asymptomatic without treatment, have been reported. In an attempt to understand this heterogeneity, we have compared 17 typical cases of MCL...
ORGANISM(S): Homo sapiens 
2013-12-23 | E-GEOD-45717 | biostudies-arrayexpress
UnknownCharacterization of monoamine oxidase-B (MAO-B) as a biomarker of reactive astrogliosis in Alzheimer's disease and related dementias.
Not available
S-EPMC10991006 | biostudies-literature
UnknownRisk assessment of 'Candidatus Liberibacter solanacearum' transmission by the psyllids Bactericera trigonica and B. tremblayi from Apiaceae crops to potato.
Not available
S-EPMC5377357 | biostudies-literature
UnknownDesigning Fast-Dissolving Orodispersible Films of Amphotericin B for Oropharyngeal Candidiasis.
Not available
S-EPMC6723921 | biostudies-literature
UnknownHow accurate are accurate force-fields for B-DNA?
Not available
S-EPMC5397185 | biostudies-literature
UnknownSolid-phase total synthesis and structure proof of callipeltin B.
Not available
S-EPMC2582558 | biostudies-literature
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