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TranscriptomicsAffymetrix SNP 6.0 profiles of 10 Human B-NHL lines
B-cell Non Hodgkin Lymphoma are a heterogenous group chracterized by a variety of genetic changes, including translocations, deletions and amplifications. Here we analyzed 10 B-NHL lines by Affymetrix SNP 6.0 to detect copy number changes. Specifically, we aim to identify cell lines suitable for te...
ORGANISM(S): Homo sapiens 
2012-04-02 | E-GEOD-36967 | biostudies-arrayexpress
ProteomicsActivity of the novel BTK inhibitor TG-1701 is associated with the disruption of the Ikaros signaling pathway in responder B-NHL patients and with sensitization to anti-CD20 therapy in B-NHL xenografts
Covalent Bruton's tyrosine kinase inhibitors (BTKis) have transformed the treatment of B-cell non-Hodgkin lymphoma (B-NHL), including chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), but their activity has been limited by off-target toxicity and acquired drug resistance. TG-1701 is...
ORGANISM(S): Homo sapiens (Human) 
2021-09-22 | PXD023231 | Pride
Xenografts Tmt B-nhl Btk Maxquant Tg-1701 Phosphoproteomics Ikaros 
TranscriptomicsCopy number variation analysis on a non-Hodgkin lymphoma case-control study identifies an 11q25 duplication associated with diffuse large B-cell lymphoma
Recent GWAS have identified several susceptibility loci for NHL. Despite these successes, much of the heritable variation in NHL risk remains to be explained. Common copy-number variants are important genomic sources of variability, and hence a potential source to explain part of this missing herita...
ORGANISM(S): Homo sapiens 
2014-09-23 | E-GEOD-58718 | biostudies-arrayexpress
Transcriptomics3D culture of AIDS-NHL cells influences gene expression related to B-cell development, proliferation and survival
Full title: Three-dimensional culture of AIDS-NHL cells influences gene expression related to B-cell development, proliferation and survival The AIDS-NHL-derived cell line, UMCL01-101, representing diffuse large B-cell lymphoma of immunoblastic morphology (AIDS-IBL), was grown in conventional, stati...
ORGANISM(S): Homo sapiens 
2010-03-07 | E-GEOD-18826 | biostudies-arrayexpress
ProteomicsProteomics after co-immunoprecipitation of myosin/MHC B/UNC-54 (with a Gly387Arg mutation) from C. elegans worms grown on nhl-1 or F40A3.6 RNAi compared to control RNAi
This project includes 20 samples after immunoprecipitation of C. elegans myosin heavy chain B (MHC B/UNC-54/F11C3.3, UniProt P02566 with a Gly387Arg mutation) in 4 replicates of 4 conditions. Lysates from a myosin-misfolding C. elegans strain (unc-54(e1301) with a Gly387Arg substitution in MHC B) gr...
ORGANISM(S): Caenorhabditis elegans 
2024-07-16 | PXD045076 | Pride
Myosin C. elegans Co-immunoprecipitation Rnai Interactome Muscle 
GenomicsPatient-Derived Lymphoma Spheroids Reveal Predictive Markers of Glofitamab Resistance in Relapsed/Refractory B-NHL
Patient-Derived Lymphoma Spheroids Reveal Predictive Markers of Glofitamab Resistance in Relapsed/Refractory B-NHL
PRJNA1309107 | ENA
TranscriptomicsMolecular characterization of the chromosome 7 in SMZL
Splenic marginal zone lymphomas (SMZL) are an uncommon type of B-cell non-Hodgkin’s lymphoma (NHL-B) in which no specific chromosomal translocations have been described. In contrast, the most frequent cytogenetic abnormality is the loss of the long arm of chromosome 7 (7q). Previous reports have loc...
ORGANISM(S): Homo sapiens 
2011-10-10 | E-GEOD-31203 | biostudies-arrayexpress
GenomicsGenome-wide maps of chromatin state in Germinal Center B cells.
Protection against deadly pathogens requires the production of high-affinity antibodies by B cells. High-affinity antibody-forming cells are generated in germinal centers (GC) as a result of a developmental program that is commonly altered in B cell malignancies. Identification of regulators of the ...
ORGANISM(S): Mus musculus 
2013-12-11 | E-GEOD-50912 | biostudies-arrayexpress
TranscriptomicsExpression data from human NHL cell lines treated with agonistic antibodies
CD20 is a clinically validated target for Non-Hodgkin’s lymphomas and autoimmune diseases. Interactions of CD20 with the B cell receptor (BCR) and components of the BCR signaling cascade have been reported. In this study we show that antibodies against CD20 or activation of the BCR by specific antib...
ORGANISM(S): Homo sapiens 
2013-07-23 | E-GEOD-23394 | biostudies-arrayexpress
GenomicsEffect of EZH2 inhibition and CART19 on gene expression of B-NHL cell lines (OCI-ly18 and SU-DHL-4)
Effect of EZH2 inhibition and CART19 on gene expression of B-NHL cell lines (OCI-ly18 and SU-DHL-4)
PRJNA1109534 | ENA
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