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ProteomicsSerial In-solution digestion protocol for mass spectrometry-based glycomics and proteomics analysis
Advancement in mass spectrometry has revolutionised the field of proteomics. However, there remains a gap in the analysis of protein post-translational modifications (PTMs), particularly for glycosylation. Glycosylation, the most common form of PTM, is involved in most biological processes; thus, an...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Mus musculus (Mouse) 
2020-04-30 | PXD017513 | Pride
Glycosaminoglycans Proteomics Mass spectrometry Glycomics Proteoglycans Fasp Extracellular matrix. 
ProteomicsIn-depth matrisome and glycoproteomic analysis of glioblastoma human brain tissue
Glioblastoma (GBM) is the most common and malignant primary brain tumor. The extracellular matrix (ECM), also known as the matrisome, helps determine glioma invasion, adhesion, and growth. Little attention, however, has been paid to glycosylation of the ECM components that constitute the majority of...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD028931 | Pride
Glycosylation Proteomics Chondroitin sulfate Glycoproteins Glycosaminoglycans Mass-spectrometry Glioblastoma Matrisome Heparan sulfate Proteoglycans Glycomics Extracellular matrix 
ProteomicsIntegrative glycomic and proteomic analysis of mouse striatum and lateral hypothalamus following cocaine and methamphetamine treatment
Drug abuse is a major concern with few therapeutic options. Heparan sulfate (HS) and chondroitin sulfate (CS) interact with a plethora of growth factors and their receptors, and have profound effects on cellular signaling. Thus, targeting these dynamic interactions represents a novel therapeutic mod...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-04 | PXD038576 | Pride
Chondroitin sulfate Mass-spectrometry Lateral hypothalamus Striatum Glycomics Drug abuse Methamphetamine Cocaine Proteomics Addiction Glycosaminoglycans Heparan sulfate Neurobiology Proteoglycans 
ProteomicsFocal clusters of peri-synaptic matrix contribute to activity-dependent plasticity and memory
Experience-dependent learning depends on synaptic plasticity. Recent findings show that effective integration of novel salient information requires coordinated processes of homo- and hetero- synaptic plasticity onto neighboring dendritic branches. In this work, we hypothesized that activity-dependen...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-10 | PXD047129 | Pride
Synaptic plasticity Cs56 clusters Extracellular matrix Versican. Learning and memory 
ProteomicsGPC3-mediated metabolic rewiring of diabetic mesenchymal stromal cells enhances their cardioprotective functions via pyruvate kinase M2 activation
Mesenchymal stromal cells (MSC) are promising stem cell therapy for treating cardiovascular and other degenerative diseases. Diabetes affects the functional capability of MSC and impedes cell-based therapy. Despite numerous studies, the impact of diabetes on MSC myocardial reparative activity, metab...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-04 | PXD055228 | Pride
Metabolomics Immunomodulation Mesenchymal stromal cells Heart failure Glypican 
ProteomicsQuantitative proteomics analysis of paired colorectal cancer and non-tumorigenic tissues reveal proteins and pathways perturbed in colorectal cancer
Proteomics is a dynamic field emerged dramatically the post genomic era which has been extensively employed to study altered protein expression to gain insight into the development process and pathways involved in cancer and uncover potential protein markers. Membrane proteomes of an expanded cohort...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-06-16 | MSV000079828 | MassIVE
ProteomicsIntegrated Proteomic and Genomic Analysis of Gastric Cancer Patient Tissues
Patient tissue samples raw data: ERBB2 positive and ERBB2 negative
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-08-05 | MSV000079211 | MassIVE
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