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ProteomicsA primary human T-cell spectral library to facilitate large scale quantitative T-cell proteomics
A primary human T-cell spectral library to facilitate large scale quantitative T-cell proteomics
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD019542 | Pride
Human t-cells Swath-ms Proteomics 
ProteomicsA primary human T-cell spectral library to facilitate large scale quantitative T-cell proteomics
Comprehensive spectral libraries are essential in sequential window acquisition of all theoretical mass spectra (SWATH-MS) based high throughput proteomic studies. Even though SWATH-MS assays provide robust quantitative proteomics data its applications to human T-cell studies are limited by the lack...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD019446 | Pride
Human Swath Spectral library Primary t-cells 
GenomicsGenetic Basis of Hepatosplenic T Cell Lymphoma (HSTL)
Hepatosplenic T cell lymphoma (HSTL) is a rare and lethal lymphoma; the genetic drivers of this disease are unknown.  Through whole exome sequencing of 68 HSTLs, we define recurrently mutated driver genes and copy number alterations in the disease. Chromatin modifying genes including SETD2, INO80 an...
EGAS00001002182 | EGA
ProteomicsCul5 regulates CD4+ T cell fate choice and allergic inflammation
Antigen encounter directs CD4+ T cells to differentiate into T-helper or -regulatory cells. This process focuses the immune response on the invading pathogen and limits tissue damage. Mechanisms that govern -helper versus -regulatory fate remain poorly understood. Here, we show that the E3 ubiquitin...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD028492 | Pride
Cis T-cell Asthma Allergy Cul5 Crl5 Cd4 Ubiquitin 
ModelsPuniya2021 - Naive CD4+ T cell metabolic model
CD4+ T cells are critical components in the human immune system. They produce cytokines to fight against pathogens and abnormal cells and stimulate other cells, such as B cells, macrophages, and neutrophils, to generate an immune response. Naive CD4+ T cells are precursor cells that can differentia...
2023-11-27 | MODEL1909260003 | BioModels
FROG 
TranscriptomicsChanges in gene expression after epigentic targeted therapy in T-cell prolymphocytic leukemia (T-PLL)
Epigenetic therapy overcame alemtuzumab resistance in patients with relapsed T-cell prolymphocytic leukemia and induced the expression of treatment related genes. Method: patient PBMCs from Ficoll, normal patient PBMCS enriched for CD3+/CD8+ or CD3+/CD8+/CD45RA+/CCR7- were extracted in Trizol. Con...
ORGANISM(S): Homo sapiens 
2015-07-08 | E-GEOD-67368 | biostudies-arrayexpress
ModelsT-LGL Survival Network 2008
T cell large granular lymphocyte (T-LGL) leukemia features a clonal expansion of antigen-primed, competent, cytotoxic T lymphocytes (CTL). To systematically understand signaling components that determine the survival of CTL in T-LGL leukemia, we constructed a T-LGL survival signaling network by inte...
2176 | Cell Collective
Genomicsena-DATASET-DAVELAB-22-03-2017-21:30:50:663-38 - samples
Whole exome sequencing of hepatosplenic T cell lymphoma (HSTL) tumors, paired normals, and cell lines, including (1) 68 exome capture, paired-end Illumina Hiseq sequencing, BAM files from HSTL tumor samples, (2) 20 exome capture, paired-end Illumina Hiseq sequencing, BAM files from HSTL paired norma...
EGAD00001003246 | EGA
UnknownApplication of a PK-PD Modeling and Simulation-Based Strategy for Clinical Translation of Antibody-Drug Conjugates: a Case Study with Trastuzumab Emtansine (T-DM1).
Not available
S-EPMC5849468 | biostudies-literature
UnknownMulti Targeted CAR-T Cell Therapies for B-Cell Malignancies.
Not available
S-EPMC6423158 | biostudies-literature
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