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TranscriptomicsGenome-wide analysis of SIK2 regulated genes and pathways
Identification of SIK2 regulated genes and pathways after SIK2 knock-down and overexpression of a wild-type and kinase-dead SIK2. The hypothesis is that SIK2 regulated gene expression via CREB1 Total RNAs were obtained after SIK2 gene was knocked down with siRNA and after a wild-type SIK2 or a kinas...
ORGANISM(S): Homo sapiens 
2015-01-12 | E-GEOD-45711 | biostudies-arrayexpress
ProteomicsSIK2-dependent Phosphoproteome and Interactome upon Salmonella infection
HeLa cells transfected with non-targeting control- and anti-SIK2 siRNA were left uninfected or infected with Salmonella and lysed 30 min pi. Following tryptic-digest peptides were labeled using TMT-pro 16-plex and phosphopeptides enriched. The endogenously tagged SIK2-HA IP workflow. Hela wild type ...
ORGANISM(S): Homo sapiens (Human) 
2021-05-06 | PXD021859 | Pride
Homo sapiens (human) 
ProteomicsSIK2 phosphorylation in response to glucagon or insulin in murine hepatocytes
The phosphorylation state of human HA-tagged-SIK2, adenovirally introduced in murine hepatocytes (C57/BL/6 strain) was analysed in unstimulated and in response to glucagon- or insulin- treated conditions. Background:- LKB1 is a master kinase that regulates metabolism and growth through AMPK and 12 o...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2014-08-08 | PXD001032 | Pride
Hepatic glucose production Hepatocytes Camp Crtc2 Ampk Glucagon Ampk-related kinase Lkb1 Sik2 Insulin Creb 
TranscriptomicsGenome-wide analysis of SIK2 regulated genes and pathways
Identification of SIK2 regulated genes and pathways after SIK2 knock-down and overexpression of a wild-type and kinase-dead SIK2. The hypothesis is that SIK2 regulated gene expression via CREB1
ORGANISM(S): Homo sapiens 
2015-01-12 | GSE45711 | GEO
UnknownSIK2 regulates CRTCs, HDAC4 and glucose uptake in adipocytes.
Not available
S-EPMC4311129 | biostudies-literature
UnknownSIK2 orchestrates actin-dependent host response upon Salmonella infection.
Not available
S-EPMC8126862 | biostudies-literature
UnknownSIK2 promotes ovarian cancer cell motility and metastasis by phosphorylating MYLK.
Not available
S-EPMC9251837 | biostudies-literature
UnknownReversible acetylation regulates salt-inducible kinase (SIK2) and its function in autophagy.
Not available
S-EPMC3585058 | biostudies-literature
GenomicsLKB1-SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition
LKB1-SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition
PRJNA976301 | ENA
UnknownSIK2 Restricts Autophagic Flux To Support Triple-Negative Breast Cancer Survival.
Not available
S-EPMC5126292 | biostudies-literature
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