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UnknownThe pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer.
Not available
S-EPMC10005955 | biostudies-literature
ProteomicsA CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation
Controlled gene expression is achieved through the intricate regulation of Pol II progression through transcription-cycle checkpoints. While the contribution of CDK9 for Pol II pause-release is well established, the requirement for other CDKs has not been fully elucidated. Here we propose a new role...
ORGANISM(S): Homo sapiens (Human) 
2025-09-09 | PXD066230 | Pride
Cdk11 Transcription Pause-release Leukaemia 
TranscriptomicsPredicting the evolution of metastatic disease in breast cancer: results from 50 years of autopsies
This is a genomic analysis of breast cancer metastasis using array based CGH and is part of a large study investigating the patterns and evolution of metastases from breast cancer using autopsy material accumulated over the last 50 years from a single institution. The samples used in the genomic pro...
ORGANISM(S): Homo sapiens 
2013-11-11 | E-GEOD-46826 | biostudies-arrayexpress
TranscriptomicsMetastatic breast cancer to the brain: set 2
Background: Metastases to the brain from breast cancer have a high mortality. Basal-like and HER2 positive breast cancers appear to have a high propensity to spread to the brain. The mechanisms that allow cells to colonise the brain are unclear. Methods: We have analysed matched and unpaired samples...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-14683 | biostudies-arrayexpress
TranscriptomicsMetastatic breast cancer to the brain: set 1
Background: Metastases to the brain from breast cancer have a high mortality. Basal-like and HER2 positive breast cancers appear to have a high propensity to spread to the brain. The mechanisms that allow cells to colonise the brain are unclear. Methods: We have analysed matched and unpaired samples...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-14682 | biostudies-arrayexpress
UnknownMetastatic breast cancer to the brain: set 2
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-14683 | biostudies-other
UnknownThe relationship between markers of antenatal iron stores and birth outcomes differs by malaria prevention regimen-a prospective cohort study.
Not available
S-EPMC8491429 | biostudies-literature
ProteomicsThe V-ATPase complex component RNAseK is required for lysosomal hydrolase delivery and autophagosome degradation
Autophagy is a finely orchestrated process required for the lysosomal degradation of cytosolic components. The final degradation step is essential for clearing autophagic cargo and recycling macromolecules. Using a CRISPR/Cas9-based screen, we identify RNAseK, a highly conserved transmembrane protei...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-02 | PXD042079 | Pride
Dia-ms Autophagosome degradation Rnasek Lysosome 
TranscriptomicsProtein Arginine Methyltransferase 6 dependent gene expression and splicing: Association with breast cancer outcomes
Protein arginine methyltransferase-6 (PRMT6) regulates steroid-dependent transcription and alternative splicing, and is implicated in endocrine system development and function, cell death, cell cycle, gene expression and cancer. Despite its role in these processes, little is known about its function...
ORGANISM(S): Homo sapiens 
2012-08-01 | E-GEOD-36542 | biostudies-arrayexpress
GenomicsWhole Genome Association Study of Bipolar Disorder

The goal of the project is to identify genes that make individuals more susceptible to bipolar disorder (manic depressive illness) and to better understand the brain pathways involved in the disease.

Dataset versioning

  • Version 1: European-American (EA) ancestr...
phs000017.v3.p1 | EGA
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