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Crohn’s disease (CD) and ulcerative colitis are chronic inflammatory bowel diseases (IBD) of which the etiology and pathogenesis are not completely understood. In paediatric patients, the disease tends to be more severe and aggressive then in adults. Here, we perform a proteomic approach on ascendin...
ORGANISM(S): Homo sapiens (Human) 
2021-08-26 | PXD024229 | Pride
Colonic aspirates were collected at diagnostic colonoscopy from inflammatory bowel disease (IBD) and control, treatment-naive children. The colonic mucosal-luminal interface (MLI) proteomes were analyzed for 18 control and 42 IBD patients by liquid-chromatography mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2018-03-19 | PXD006383 | Pride
Mucosal-luminal interface (MLI) samples were collected from a cohort of children with new-onset IBD and microbial cells were harvested and processed for metaproteomic analysis. Deep metaproteomics data analysis was then performed for better understanding the MLI microbiota functions in the developme...
ORGANISM(S): human gut metagenome 
2018-08-03 | PXD007819 | Pride
Microbial dysbiosis has been identified in adult inflammatory bowel disease (IBD) patients. However, microbial composition and functional interplay between host genetics and microorganisms in early IBD onset remain poorly defined. Here, we identified and demonstrated the causal effect of Atopobium ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD000690 | Pride
We sought to identify proteins that enable differentiation between CD and UC in children with new onset IBD. Mucosal biopsies were obtained from children undergoing baseline diagnostic endoscopy prior to therapeutic interventions. Using a super-stable isotope labeling with amino acids in cell cultur...
ORGANISM(S): Homo sapiens (Human) 
2018-11-06 | PXD005086 | Pride
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