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TranscriptomicsDNA copy number profiles of premalignant endobronchial lesions: a validated predictor for endobronchial cancer
Individuals who present with premalignant endobronchial lesions are considered at high risk of lung cancer. Nonetheless, premalignant lesions behave erratically and only a minority progresses towards lung cancer. Therefore, biomarkers need to be discovered that can aid in assessing an individual’s r...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-45287 | biostudies-arrayexpress
TranscriptomicsDetecting novel genes with sparse arrays
Species-specific genes play an important role in defining the phenotype of an organism. However, current gene prediction methods can only efficiently find genes that share features such as sequence similarity or general sequence characteristics with previously known genes. Novel sequencing methods a...
ORGANISM(S): Hypocrea jecorina 
2010-08-12 | E-GEOD-12960 | biostudies-arrayexpress
UnknownAAV2-BDNF promotes respiratory axon plasticity and recovery of diaphragm function following spinal cord injury.
Not available
S-EPMC6894085 | biostudies-literature
ProteomicsEffect of the combined loss of tomosyn (STXBP5) and tomosyn-2 (STXBP5L) on the proteome of primary mouse hippocampal neurons
Tomosyn (STXBP5) is a non-canonical SNARE protein enriched in many secretory cells and implicated in regulation of exocytosis. In neurons, loss of tomosyn affects fusion of synaptic vesicles. Here, we examined the impact of the loss of tomosyn (STXBP5) and its close paralog, tomosyn-2 (STXBP5L), on ...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-19 | PXD038442 | Pride
Tomosyn Stxbp5 Swath Neuron Synapse Mouse Primaryculture 
TranscriptomicsTranscription profiling of human NF1 heterozygous (NF1+/-) melanocytes from a Neurofibromatosis type 1 patient and NF1 wild type (NF1+/+) melanocytes of a healthy control patient
One of the major primary features of the neurocutaneous genetic disorder Neurofibromatosis type 1 are the hyperpigmentary café-au-lait macules where dysregulation of melanocyte development, proliferation and differentiation is considered to play a key etiopathogenic role. To gain better insight in t...
ORGANISM(S): Homo sapiens 
2005-02-05 | E-MEXP-258 | biostudies-arrayexpress
TranscriptomicsGene Expression in Prokaryotic Microbial Assemblages Across Salinity Gradients in the Columbia River Coastal Margin
Analysis of microbial gene expression in response to physical and chemical gradients forming in the Columbia River, estuary, plume and coastal ocean was done in the context of the environmental data base. Gene expression was analyzed for 2,234 individual genes that were selected from fully sequenced...
ORGANISM(S): uncultured prokaryote 
2010-09-10 | E-GEOD-18303 | biostudies-arrayexpress
OtherCooperative induction of apoptosis in nras mutant melanoma by inhibition of mek and rock
Data from ProteomeXchange, PXD ID: PXD000528. Experiment: GM_NKI_NRAS_Phospho_Mix2, file: OR9_20130426_GM_NKI_NRAS_Phospho_Mix2_repl1_ReRunFr10.mzml. Published as part of Pigment Cell Melanoma Res. 2015 Feb 28 . From the Abstract: {{i}} No effective targeted therapy is currently available for NRAS ...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320014056 | GPMDB
Resource Reanalysis 
ProteomicsInteractomes of GluA1 and GluA3 subunit containing AMPARs reveal distinct protein composition
The AMPA glutamate receptor (AMPAR) is the major type of synaptic excitatory ionotropic receptor in the brain. The most abundant AMPAR subtypes in the hippocampus are GluA1/2 and GluA2/3 heterotetramers. Each subtype contributes differentially to mechanisms of synaptic plasticity, which may be in pa...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-12 | PXD031603 | Pride
Proteomics Prrt1 Glua1/2 Tarp- γ8 Subcomplexes Ampar Glua2/3 Ms-dap 
UnknownAre Patient Expectations and Illness Perception Associated with Patient-reported Outcomes from Surgical Decompression in de Quervain's Tenosynovitis?
Not available
S-EPMC8052037 | biostudies-literature
ProteomicsReduced mGluR5 activity modulates mitochondrial function in the synapse
The metabotropic glutamate receptor 5 (mGluR5) is a G-protein coupled receptor with an important role in synaptic function at multiple levels. In physiological conditions, mGluR5 is an essential modulator of synaptic plasticity, learning and memory; whereas in pathological conditions, it is an ackno...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-27 | PXD023809 | Pride
Mitochondria Dia Swath Brain Metabotropic glutamate receptor 5 Synapse Mass spectrometry Mice Mglur5 Ctep 
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