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MetabolomicsIntegrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection
The metabolic effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on human blood plasma were characterized using multi-platform metabolic phenotyping with Nuclear Magnetic Resonance (NMR) spectroscopy and liquid chromatography-mass spectrometry (LC-MS). Quantitative mea...
2021-01-29 | MTBLS2014 | MetaboLights
MetabolomicsGNPS-Passive accumulation of alkaloids in non-toxic frogs challenges paradigms of the origins of acquired chemical defenses
Paper Title: Passive accumulation of alkaloids in non-toxic frogs challenges paradigms of the origins of acquired chemical defenses. Author List; Rebecca D Tarvin, Jeffrey L Coleman, David A Donoso, Mileidy Betancourth-Cundar, Karem Lopez-Hervas, Kimberly S Gleason, J Ryan Sanders, Jacqueline M Smit...
ORGANISM(S): Multiple Frog Species 
MSV000095866 | GNPS
ProteomicsAngiogenic and Immunologic Proteins Identified by Deep Proteomic Profiling of Human Choroidal and Retinal Vascular Endothelial Cells
PURPOSE Diseases that involve choroidal or retinal endothelial vascular cells are leading causes of vision loss: age-related macular degeneration, retinal ischemic vasculopathies and non-infectious posterior uveitis. Proteins differentially expressed by these endothelial cell populations are potenti...
ORGANISM(S): Homo sapiens (Human) 
2018-03-26 | PXD005972 | Pride
Protein expression Mudpit Tandem mass spectrometry Human Cell culture Endothelial cells Proteomics Choroid Linear ion trap Spectral counting Retina 
ProteomicsIdentifying a novel hydroxysteroid dehydrogenase enzyme that is capable of testosterone biosynthesis in the mouse
Androgens, such as testosterone and dihydrotestosterone (DHT), are essential for male sexual development, masculinisation, spermatogenesis, and general lifelong health. Androgens are predominantly synthesised in the testes of mice (~95%) by highly specialised cells known as the Leydig cells. There a...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-12 | PXD050748 | Pride
Androgens Alternate pathway Hsd17b7 Canonical pathway Testosterone Srd5a1 Testosterone biosynthesis Hsd17b3 
TranscriptomicsA unique role of Cohesin-SA1 in gene regulation and development
This SuperSeries is composed of the following subset Series: GSE32234: A unique role of Cohesin-SA1 in gene regulation and development [Expression] GSE32319: A unique role of Cohesin-SA1 in gene regulation and development [Chip-Seq] Refer to individual Series
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-32320 | biostudies-arrayexpress
ProteomicsProteogenomic Analysis of Human Colon Carcinoma Cell Lines LIM1215, LIM1899 and LIM2405
In this study, we have integrated shotgun proteomics approach to compare the protein expression profiles of 3 human colon cancer cell lines (LIM1215, LIM1899 and LIM2405) representing alternative forms of colorectal cancer. We have performed detailed analysis of our proteomics data (coupled with RNA...
ORGANISM(S): Homo sapiens (Human) 
2013-03-13 | PXD000120 | Pride
Colon cancer 
TranscriptomicsSmall Marine Neurotoxin Elicits Common Antibody Response in Zebrafish and Sea Lions
The neurotoxic amino acid, domoic acid, is naturally produced by marine phytoplankton and presents a significant health threat to marine mammal and human populations. Currently, diagnostic tools to assess exposure are not available, yet concerns regarding health impacts associated with low-level re...
ORGANISM(S): Danio rerio 
2013-01-03 | E-GEOD-34716 | biostudies-arrayexpress
GenomicsA unique role of Cohesin-SA1 in gene regulation and development [ChIP-Seq]
Vertebrates have two cohesin complexes that consist of Smc1, Smc3, Rad21/Scc1 and either SA1 or SA2, but their functional specificity is unclear. Mouse embryos lacking SA1 show developmental delay and die before birth. Comparison of the genome wide distribution of cohesin in wild-type and SA1-null c...
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-32319 | biostudies-arrayexpress
TranscriptomicsmicroRNAs in C. elegans, P. pacificus, and S. ratti: Conserved miRNAs are candidate post-transcriptional regulators of developmental arrest in free-living and parasitic nematodes
Animal development is complex yet surprisingly robust. Animals may develop alternative phenotypes conditional on environmental changes. Under unfavorable conditions C. elegans larvae enter the dauer stage, a developmentally arrested, long-lived, and stress-resistant state. Dauer larvae of free-livin...
ORGANISM(S): Pristionchus pacificus 
2013-07-04 | E-GEOD-41402 | biostudies-arrayexpress
ProteomicsSplice-Switching Oligonucleotide-mediated Correction of a Deep Intronic Splice-variant in TIMMDC1 in Cells of Patients with Severe Early Onset Neurodegenerative Disorder.
TIMMDC1 encodes the Translocase of Inner Mitochondrial Membrane Domain-Containing protein 1 (TIMMDC1) subunit of complex I of the electron transport chain responsible for ATP production. We studied a consanguineous family with two affected children, now deceased, who presented with failure to thrive...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD029707 | Pride
Human Sso Dia Mitochondrial disease Timmdc1 
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