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MetabolomicsDifferent regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly
Vesicle associated membrane protein 2 (VAMP2/synaptobrevin2), a core SNARE protein residing on synaptic vesicles (SVs), forms helix bundles with syntaxin-1 and SNAP25 for the SNARE assembly. Prior to the SNARE assembly, the structure of VAMP2 is unclear. Here, by using in-cell NMR spectroscopy, we d...
2021-10-06 | MTBLS1503 | MetaboLights
ProteomicsSyntaxin5’s flexibility in SNARE pairing supports Golgi functions
The intracellular transport system is an evolutionally conserved, essential, and highly regulated network of organelles and small transport carriers that traffic protein and lipid cargoes within the cell. The Conserved Oligomeric Golgi (COG) complex is the major Golgi Multisubunit Tethering Complex....
ORGANISM(S): Homo sapiens (Human) 
2023-06-26 | PXD036741 | Pride
Membrane trafficking Golgi Bet1l Vti1b Snap29 Gor1 Gosr2 Cog Snares Stx5 Ykt6 
ProteomicsMass Spectrometry Uncovers Protein Interactions and Stoichiometry of Intermediates and Sub-complexes for SNARE Complex Assembly
The neuronal SNARE complex assembles from vesicular Synaptobrevin-2 as well as Syntaxin-1 and SNAP25 anchored to the presynaptic membrane. It mediates fusion of synaptic vesicles with the presynaptic plasma membrane resulting in exocytosis of neurotransmitters into the synaptic cleft. While the gene...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-01-25 | PXD030619 | Pride
Native mass spectrometry Chemical cross-linking Snare complex Complexin-1 Signal transmission in neurons 
UnknownSNARE zippering requires activation by SNARE-like peptides in Sec1/Munc18 proteins.
Not available
S-EPMC6130351 | biostudies-literature
ProteomicsDeficiency in the SNARE protein SYNTAXIN-11 causes a secondary B cell defect
CD4 T cell help requires functional SNARE protein SYNTAXIN-11 for successful interaction with B cells, CD40L mobilization and secretion of IL-2 and IL-10 to promote B cell differentiation, germinal centre formation and class switch. STX11-deficieny results in hypogammaglobulinemia suggesting a highe...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-03-01 | MSV000094210 | MassIVE
ProteomicsSerine ubiquitination of SNAREs generates bacterial vacuoles and prevents their lysosomal fusion
Here we show that Legionella SidE effectors mediate phosphoribosyl-linked serine ubiquitination (PR-Ub) of the autophagic SNARE proteins STX17 and SNAP29. On the one hand, PR-Ub modification of STX17 enhances its interaction with ATG14L, which drives the recruitment of ER membranes to the bacterial ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-14 | PXD058184 | Pride
Legionella pneumophila Xenophagy Syntaxin17 Ubiquitin Autophagy 
UnknownThe Multifaceted Role of SNARE Proteins in Membrane Fusion.
Not available
S-EPMC5247469 | biostudies-literature
ProteomicsMiniTurbo-based interactomics of two plasma membrane-localized SNARE proteins in Marchantia polymorpha
• Marchantia polymorpha is a model liverwort and its overall low genetic redundancy is advantageous for dissecting complex pathways. Proximity-dependent in vivo biotin-labelling methods have emerged as powerful interactomics tools in recent years. However, interactomics studies applying proximity la...
ORGANISM(S): Marchantia polymorpha 
2022-04-01 | PXD030429 | Pride
Snare protein Interactomics Membrane-trafficking Miniturbo Proximity labelling Marchantia polymorpha 
UnknownSelf-assembly of SNARE fusion proteins into star-shaped oligomers.
Not available
S-EPMC1186695 | biostudies-literature
UnknownSNARE proteins: zip codes in vesicle targeting?
Not available
S-EPMC8883487 | biostudies-literature
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