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TranscriptomicsTranscription profiling of Saccharomyces cerevisiae mutant delta-spe3 delta-fms1 after spermidine treatment
The naturally occurring polyamines putrescine, spermidine or spermine are ubiquitous in all cells. Although polyamines have prominent regulatory roles in cell division and growth, precise molecular and cellular functions are not well established in vivo. In this work we have performed a microarray e...
ORGANISM(S): Saccharomyces cerevisiae 
2009-09-05 | E-GEOD-15269 | biostudies-arrayexpress
MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
ProteomicsEvaluation of N8-propargyl spermidine and spermine as substrates of deoxyhypusine synthase in the in vitro hypusination of eIF5A and RIPK1
eIF5A is a well-established protein substrate of deoxyhypusine synthase (DHS), which also requires spermidine as a small-molecule substrate. At the end of 2024, a publication claimed that RIPK1 is an additional DHS substrate and that N8-propargyl spermidine can also serve as a DHS substrate. To eval...
ORGANISM(S): Homo sapiens (Human) 
2026-03-13 | PXD071577 | Pride
N8-propargyl spermidine Dhs Eif5a Chemical probe Hypusination Deoxyhypusine synthase Ripk1 
ProteomicsProfiling proteome changes during polyamine depletion within the Leishmania donovani polyamine pathway gene deletion mutants, del-odc (ornithine decarboxylase) and del-spdsyn (spermidine synthase)
Polyamines are aliphatic polycations that have emerged as important determinants of cell growth and viability in rapidly proliferating cells, including in the pathogenic protozoan parasite Leishmania donovani. In L. donovani, the polyamine spermidine is synthesized by the successive conversion of or...
ORGANISM(S): Leishmania donovani BPK282A1 
2022-08-29 | PXD036349 | Pride
Psr-ohsu Leishmania Starvation Ornithine decarboxylase Stress-response Spermidine synthase Quantitative proteomics Polyamine Tandem mass tags 
ProteomicsEvaluation of N8-propargyl spermidine as a substrate of deoxyhypusine synthase in cellulo
Two complementary experiments were performed to evaluate whether N8-propargyl spermidine is a substrate of deoxyhypusine synthase in cells. HEK293 and mouse embryonic fibroblast (MEF) cells were incubated with either N8-propargyl spermidine or spermidine, lysed, and subjected to CuAAC ligation with ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-03-13 | PXD071477 | Pride
Chemical probe Hypusination Hek293 N8-propargyl spermidine Mef 
ProteomicsEvaluation of N8-propargyl spermidine (Probe 1) as a substrate of deoxyhypusine synthase in cellulo
Two complementary experiments were performed to evaluate whether N8-propargyl spermidine is a substrate of deoxyhypusine synthase in cells. HEK293 and mouse embryonic fibroblast (MEF) cells were incubated with either N8-propargyl spermidine (Probe 1) or spermidine, lysed, and subjected to CuAAC liga...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-06-23 | PXD080059 | Pride
N8-propargyl spermidine Mef Chemical probe Hypusination Hek293 
GenomicsCancer cell-secreted spermidine synthase induces skeletal muscle fibrosis upon radiotherapy (Gastrocnemius muscle)
Cancer cell-secreted spermidine synthase induces skeletal muscle fibrosis upon radiotherapy (Gastrocnemius muscle)
PRJNA1097658 | ENA
GenomicsCancer cell-secreted spermidine synthase induces skeletal muscle fibrosis upon radiotherapy (Xenograft tumor)
Cancer cell-secreted spermidine synthase induces skeletal muscle fibrosis upon radiotherapy (Xenograft tumor)
PRJNA1097659 | ENA
GenomicsCancer cell-secreted spermidine synthase induces skeletal muscle fibrosis upon radiotherapy (Gastrocnemius muscle KD)
Cancer cell-secreted spermidine synthase induces skeletal muscle fibrosis upon radiotherapy (Gastrocnemius muscle KD)
PRJNA1097657 | ENA
GenomicsCancer cell-secreted spermidine synthase induces skeletal muscle fibrosis upon radiotherapy (MDA-MB-231)
Cancer cell-secreted spermidine synthase induces skeletal muscle fibrosis upon radiotherapy (MDA-MB-231)
PRJNA1097655 | ENA
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