Sort   by:  
 Page size 
ProteomicsEstimating the Contribution of Proteasomal Spliced Peptides to the HLA-I Ligandome
Spliced peptides are short protein fragments spliced together in the proteasome by peptide bond formation. True estimation of the contribution of proteasome-spliced peptides (PSPs) to the global Human Leukocyte Antigen (HLA) ligandome is critical. A recent study suggested that PSPs contribute up to ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-11-13 | MSV000086452 | MassIVE
ProteomicsMelanoma spliced and linear HLA-I peptides
In this project we have identifed and linear and spliced HLA-I bound peptides to LM-MEl-44, 53 and 33 cell lines in two different condition, treated and not treated with interferone gamma.
ORGANISM(S): Homo sapiens (Human) 
2020-09-25 | PXD014397 | Pride
Spliced peptides Melanoma Hla peptides 
ProteomicsKRAS G12V spliced neoepitope is produced by proteasomes
This dataset contains further evidence that the HLA-A*02:01+ KRAS G12V+ spliced neoepitope we previously identified (Mishto et al., Front. Immunol. 2019) is produced by proteasomes in various experimental conditions
ORGANISM(S): Homo sapiens (Human) 
2022-09-05 | PXD024528 | Pride
Mass spectrometry Epitope discovery Peptide splicing Proteasome Cis-spliced peptides Kras 
ProteomicsEstimating the Contribution of Proteasomal Spliced Peptides to the HLA-I Ligandome
Spliced peptides are short protein fragments spliced together in the proteasome by peptide bond formation. True estimation of the contribution of proteasome-spliced peptides (PSPs) to the global Human Leukocyte Antigen (HLA) ligandome is critical. A recent study suggested that PSPs contribute up to ...
ORGANISM(S): Homo sapiens (Human) 
2018-09-03 | PXD010793 | Pride
Lc-msms Immunopeptidomics Proteasomal splicing Hla-i peptides 
ProteomicsDatabase search engines and target database features impinge upon the identification of post-translationally cis-spliced peptides in HLA class I immunopeptidomes
Unconventional epitopes presented by HLA class I complexes are emerging targets for T cell targeted immunotherapies. Their identification by mass spectrometry required development of novel methods to cope with the large number of theoretical candidates. Methods to identify post-translationally splic...
ORGANISM(S): Homo sapiens (Human) 
2022-04-06 | PXD031709 | Pride
K562 cell line Mass spectrometry Peptide splicing Immunopeptidome Hla-i Cis-spliced peptides 
ProteomicsIdentification of spliced peptides in pancreatic islets uncovers errors leading to false assignments
Spliced peptides have been identified in the class I major histocompatibility complex (MHC) peptidomes of several tumors and have emerged as novel autoantigens that can stimulate highly specific T cells. A special class of spliced peptides, hybrid insulin peptides (HIPs), bound to histocompatibility...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-02-11 | PXD019819 | Pride
Mhc-i peptidome Crinosomes 
ProteomicsSPI-ART and the features of cis-spliced peptides in HLA class I immunopeptidomes
The identification of peptides presented by HLA class I molecules to CD8+ T cells – i.e. the HLA-I immunopeptidome - is a useful tool to fish epitopes suitable for vaccinations and immunotherapies against cancer, infection and autoimmunity. These peptides are mainly generated by proteasomes through ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD025346 | Pride
K562 cell line Mass spectrometry Peptide splicing Immunopeptidome Hla-i Cis-spliced peptides 
ProteomicsElucidation of the Signatures of Proteasome-Catalyzed Peptide Splicing
Proteasomes catalyze the degradation of endogenous proteins into oligopeptides, but can concurrently create spliced oligopeptides through ligation of previously non-contiguous peptide fragments. Recent studies have uncovered a formerly unappreciated role for proteasome-catalyzed peptide splicing (PC...
ORGANISM(S): Homo sapiens (Human) Human immunodeficiency virus 
2021-05-17 | PXD025893 | Pride
Peptide spliicng Proteasome Antigen processing 
ProteomicsContribution of proteasome-catalyzed peptide cis-splicing to viral targeting by CD8+ T cells in HIV-1 infection
Peptides generated by proteasome-catalyzed splicing of non-contiguous amino acid sequences have been shown to constitute a source of non-templated human leukocyte antigen class I (HLA-I) epitopes, but their role in pathogen-specific immunity remains unknown. CD8+ T cells are key mediators of human i...
ORGANISM(S): Homo sapiens (Human) HIV-1 vector pNL4-3 
2019-11-25 | PXD015489 | Pride
Spliced epitope Peptide splicing Viral escape Mass spectrometry Cd8+ t cell Epitope discovery Proteasome Human leukocyte antigen Immunopeptidome Human immunodeficiency virus 
TranscriptomicsRNA sequencing of HEK293T cells expressing peptide 9J10, a 14-3-3 interacting peptide
We investigated the transcriptome profile of HEK293T cells transfected with a plasmid encoding 9J10, a peptide isolated in a phenotypic screen from a library of peptides derived from bacterial and archaeal genomes. The peptide was identified in a screen for FOXO3a reactivation and has been shown to...
ORGANISM(S): Homo sapiens 
2021-05-28 | E-MTAB-10161 | biostudies-arrayexpress
Sort   by:  
 Page size