Sort   by:  
 Page size 
MetabolomicsNorbergenin prevents LPS-induced inflammatory responses in macrophages through inhibiting NFkB, MAPK and STAT3 activation and blocking metabolic reprogramming

Inflammation is thought to be a key cause of many chronic diseases and cancer. However, current therapeutic agents to control inflammation have limited long-term use potential due to various side-effects. This study aimed to examine norbergenin, a constituent of traditional anti-inflammatory reci...

2023-04-06 | MTBLS7127 | MetaboLights
ProteomicsDUSP2 dephosphorylates STAT3 at Y705 and S727 residues
In the related study, to determine whether DUSP2 definitively served as a phosphatase for STAT3, an in vitro phosphatase assay was used. Using S-tag beads, p-STAT3 was pulled down from IL-6 stimulated HEK293T cells transfected with STAT3-S-Tag. DUSP2 or control protein, which was purified from HEK29...
ORGANISM(S): Homo sapiens (Human) 
2015-10-13 | PXD002743 | Pride
Dusp2 Phosphorylation Stat3 
ProteomicsRole of Stat3 phosphorylation in Th17 differentiation
Determine the role of stat3 phosphorylation, particularly at S727, during the differentiation of Th17 cells.
ORGANISM(S): Mus musculus (Mouse) 
2025-10-29 | PXD059588 | Pride
Th17 stat3 
TranscriptomicsTranscription profiling of mouse IL-10 -/- macrophages treated with LPS/LPS plus IL10 reveals a transcriptional repressor and co-repressor induced by the STAT3-regulated anti-inflammatory signaling pathway.
IL-10 regulates anti-inflammatory signaling via the activation of STAT3, which in turn controls the induction of a gene expression program whose products execute inhibitory effects on pro-inflammatory mediator production. Here we show that IL-10 induces the expression of an ETS family transcriptiona...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9509 | biostudies-arrayexpress
TranscriptomicsOpposing Roles of STAT1 and STAT3 in IL-21 Function in CD4+ T cells
Interleukin-21 (IL-21) is a type 1 cytokine essential for immune cell differentiation and function. Although IL-21 can activate several STAT family transcription factors, previous studies focused mainly on the role of STAT3 in IL-21 signaling. Here, we investigated the role of STAT1 and show that ST...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-63204 | biostudies-arrayexpress
ProteomicsCIP2A negatively regulates Th17 differentiation
Interleukin 17 (IL-17) producing T helper 17 (Th17) cells are critical drivers of pathogenesis in a variety of autoimmune and inflammatory diseases. Strategies to mitigate excessive Th17 response thus remain an attractive target for immunotherapies. Here we report that Cancerous Inhibitor of Protein...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD010612 | Pride
Th17 cell differentiation Stat3 phosphorylation 
ProteomicsProteome and Modification of Stat3 and Malt1 dependent on Hectd3
We transfected HEK293T cells with HA-Ub, Flag-Stat3 or Flag-Malt1A, with or without Xpress-Hectd3. We performed Flag immunoprecipitation then conducted LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2019-01-16 | PXD011756 | Pride
Th17 cells Eae Hectd3 Stat3 activation Multiple sclerosis K29-lniked polyubiquitin chain Malt1 Neuroinflammation Ubiquitination Pstat3 y705 K27-linked polyubiquitin chain Stat3 phosphorylation Stat3 
TranscriptomicsInhibition of dendritic cell maturation and effector function
The initiation of donor derived dendritic cell (DC) adhesion and migration are one of the key events mediated by ischemia reperfusion injury (IRI) following solid organ transplantation. Recently we have been able to demonstrate that a single donor treatment with the synthetic metalloporphyrin cobalt...
ORGANISM(S): Mus musculus 
2010-05-18 | E-GEOD-8452 | biostudies-arrayexpress
ProteomicsA Bartonella effector acts as signaling hub for intrinsic STAT3 activation to trigger anti-inflammatory responses
Chronically infecting pathogens avoid clearance by the innate immune system by promoting premature transition from an initial pro-inflammatory response towards an anti-inflammatory tissue-repair response. STAT3, a central regulator of inflammation, controls this transition and thus is targeted by nu...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-12 | PXD017119 | Pride
Signaling Bartonella Stat3 
TranscriptomicsRNA-seq analysis of IL-10 treatment of wildtype and Ptpn1-/- knockout peritoneal macrophages
We report here the deep sequencing of the mRNA from peritoneal exudate cells (macrophages) purified from wildtype or Ptpn1 (PTP1B) knockout mice, either treated or untreated with IL-10. In periotenal macrophages IL-10 activates the transcription factor STAT3 to execute and anti-inflammatory gene exp...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-49449 | biostudies-arrayexpress
Sort   by:  
 Page size