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ProteomicsNucleoside Binding by a Surface Lipoprotein Governs Conjugative ICE Acquisition in Ruminant Mycoplasmas
This project aims to investigate whether the surface lipoproteins CDS14 and P48, both required for ICEA-mediated conjugation in Mycoplasma agalactiae, physically interact during mating. CDS14 is encoded by ICEA and constitutively expressed in donor cells, whereas P48 is expressed by both donor and r...
ORGANISM(S): Mycoplasma agalactiae 
2025-12-19 | PXD068569 | Pride
Mycoplasma  integrative and conugative elements (ice)  lipoprotein p48 
ProteomicsMycobacterium tuberculosis fingerprint in human lungs
Tuberculosis (TB) is one of the top ten causes of death worldwide and the leading cause of death from a single infectious agent. Globally, an estimated of 10 million people developed TB in 2018 according to WHO report. An estimated one third of all TB cases are not diagnosed or notified, partly due ...
ORGANISM(S): Mycobacterium tuberculosis H37Rv Homo sapiens (Human) Mycobacterium tuberculosis 
2023-03-10 | PXD028477 | Pride
Lipid Tuberculosis Exhaled breath condensate Diagnosis Lipoarabinomannan Protein 
ProteomicsProcessing of microbial glycolipids in lysosome expands the repertoire of TLR2 agonists
The goal is to demonstrate that a fraction of lysosomal proteins purified from THP1 cells contains lipolytic activities capable of digesting a cell envelope compound (a tetra-acylated PIM) to generate acyl-forms not produced by Mtb.
ORGANISM(S): Homo sapiens (Human) 
2026-09-09 | PXD051087 | Pride
Receptor Cd1b Mycobacterium Acylation Lysosome Lipase 
ProteomicsOverexpression of the mycobacterial PknB Ser/Thr kinase uncovers its global regulatory role in mycolic acids biosynthesis and trafficking
Comparison of the global phospho-proteomes of Mycobacterium smegmatis wild type, and over-expressing the protein kinase PknB from Mycobacterium tuberculosis or its enzymatically inactive K40M isoform.
ORGANISM(S): Escherichia coli 
2021-08-30 | PXD012553 | Pride
Mycobacterium smegmatis phosphoproteomics nanohlpc-ms/ms 
ProteomicsRv0180c contributes to M. tuberculosis cell shape and to infectivity in mice and host cells
Mycobacterium tuberculosis, the main causative agent of human tuberculosis, is transmitted from person to person via small droplets containing very few bacteria. Optimizing the chance to seed in the lung is therefore a major adaptation to favor survival and dissemination in the human population. He...
ORGANISM(S): Mycobacterium tuberculosis H37Rv_2009 
2022-02-16 | PXD024319 | Pride
Mycobacterium tuberculosis h37rv Lc-ms/ms 
ProteomicsLysosome proteomics from muscle cell in CTRL and X-linked centronuclear myopathy models
Lyso-Tag (3XHA-TMEME-192) isolation and purification followed by proteomic analysis in C2C12 vs MTM1-KO myotubes (4 replicates for each group)
ORGANISM(S): Mus musculus (Mouse) 
2026-02-09 | PXD065512 | Pride
Muscle cells/myotube Raggtpase Mtorc1 Lamtors Mtm1 Phosphonositides 
UnknownImpact of Switching from Twice-Daily Basal Insulin to Once-Daily Insulin Glargine 300 U/mL in People with Type 1 Diabetes on Basal-Bolus Insulin: Phase 4 OPTIMIZE Study.
Not available
S-EPMC6995801 | biostudies-literature
ProteomicsA potent cytidine deaminase biodegrader sensitises cancer cells to deoxycytidine analogue-based chemotherapies
Deoxycytidine analogues (dC) are chemotherapy agents used to treat a range of solid and blood cancers. However, their clinical efficacy is often limited by resistance mechanisms. Cytidine deaminase (CDA) plays a key role of this resistance by deaminating dC analogues into inactive metabolites. Altho...
ORGANISM(S): Homo sapiens (Human) 
2026-08-24 | PXD065390 | Pride
Targeted protein degradation Cytarabine Cytidine deaminase Chemotherapy resistance Single domain antibody Lung cancer Biodegrader Pancreatic cancer Gemcitabine 
ProteomicsCohesin interacting partners before and after DSB induction
Here we made use of a human osteosarcoma U-2 OS modified cell line (U-2 OS DIvA- Flag-GFP-SMC1), expressing a hydroxytamoxifen controlled restriction enzyme (AsiSI-ER which allows the induction of multiple annotated DSBs) and Flag GFP-SMC. We performed tandem purification before and after DSB induct...
ORGANISM(S): Homo sapiens (Human) 
2025-04-29 | PXD062315 | Pride
Lc-msms Human osteosarcoma cell Cohesin Dsb 
ProteomicsIntegrative analysis of the native ethanolamine utilization bacterial microcompartment system in Escherichia coli.
Bacterial microcompartments (BMCs) represent prokaryotic counterparts to the eukaryotic organelles. BMCs act as intracellular microbioreactors that spatially insulate targeted pathways and enhance their kinetics through metabolic channelling effects. Some strains of E. coli natively bear an ethanola...
ORGANISM(S): Escherichia coli 
2024-07-02 | PXD048973 | Pride
Escherichia Bacterial microcompartment Ethanolamine 
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