Sort   by:  
 Page size 
ProteomicsThe C-terminal end of engineered albumin variants and fusion proteins after exposure to carboxypeptidase A
Albumin has a long plasma half-life due to engagement of the neonatal Fc receptor (FcRn), which prevents intracellular degradation. However, its C-terminal end can be cleaved by carboxypeptidase A, and removal of the last leucine residue (L585) weakens receptor binding, reducing its half-life from 2...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-05-19 | PXD063561 | Pride
Albumin engineering Carboxypeptidase a The neonatal fc receptor (fcrn) Albumin-fusion proteins 
ProteomicsComparative Proteomics and micro-RNA analysis of Skeletal Muscle Cell Small Extracellular vesicles - Unique Profiles in Cells from Severely Obese Individuals with Type 2 Diabetes versus Normal Glucose Tolerance
: Type 2 diabetes (T2D) is associated with increased morbidity, mortality, and substantial healthcare costs. Peripheral insulin resistance, involving interconnected dysregulation of multiple organs, is considered a major driver of T2D. Extracellular vesicles (EVs) are suggested as mediators of this ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD068287 | Pride
Microrna Myotube Extracellular vesicles Type 2 diabetes Proteomics Obesity Skeletal muscle 
ProteomicsProteomic analysis of gemcitabine-resistant (GemR) versus paired control human pancreatic cancer cells (PCCs)
In search of potential markers of treatment response, comparative LC-MS/MS-based proteomic analysis of GemR and paired control PCCs was performed. It includes four different PCC lines including three primary - PCC-1 (c1), PCC-2 (c2), PCC-7 (c3) and Mia PaCa-2 (c4). Cells were maintained in DMEM supp...
ORGANISM(S): Homo sapiens (Human) 
2025-11-03 | PXD063320 | Pride
Proteome profiling Pancreatic cancer Gemcitabine resistance Lc-ms/ms 
ProteomicsHEK293 WT and ATP6AP1 knockout cells treated with and without mitochondrial translation inhibitors
Label-free whole-cell proteomics. Dataset 1: 15-days low-dose treatment with EtOH, 15uM ACT, 5ug/ml CAP or the combination ACT CAP in HEK293 WT cells. Dataset 2: 3-days low dose treatment with EtOH or 15uM ACT in HEK293 Cas9 and ATP6AP1 knockout cells
ORGANISM(S): Homo sapiens (Human) 
2025-11-20 | PXD050818 | Pride
Mitochondrial Mass spectrometry Ek293 wt Atp6ap1 
ProteomicsIntrinsic errors in mitochondrial translation trigger a decline in cell fitness
Defects in the faithful expression of the human mitochondrial genome underlies disease states, from rare inherited disorders to common pathologies and the aging process itself. The ensuing decrease in the capacity for oxidative phosphorylation alone cannot account for the phenotype complexity assoc...
ORGANISM(S): Mus musculus (Mouse) 
2026-10-02 | PXD069822 | Pride
Mitochondria  aging  protein synthesis  innate immunity  metabolism 
ProteomicsImmunoprecipitation/Pull-down of ATP6AP1-FLAG in HEK293 WT cells treated with and without a mitochondrial translation inhibitor
Dataset: HEK293 WT cells were transfected with ATP6AP1-FLAG expression vector for 96h, with or without the presence of 15uM actinonin, a mitochondrial translation inhibitor. Immunoprecipitation was performed using FLAG antibody and Protein-G Sepharose, and the samples were analysed with label-free w...
ORGANISM(S): Homo sapiens (Human) 
2025-11-20 | PXD057148 | Pride
Atp6ap1/ac45 Crispr/cas9 Mitochondrial translation Organellar cross-talk V-atpase Proteostasis Mitochondrial disease Retrograde signalling 
ProteomicsProteomic evaluation and comparison of native and decellularized human saphenous vein extracellular matrices
This project presents a label-free quantitative proteomic analysis of human saphenous vein (hSV) before and after decellularization, i.e. removal of cellular material using a CHAPS-based protocol. The study evaluated extracellular matrix preservation, vascular basement membrane composition changes, ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-17 | PXD068043 | Pride
Vascular tissue engineering Human saphenous vein Vascular graft Cardiovascular diseases Tissue decellularization Extracellular matrix Vascular basement membrane Regenerative medicine 
ProteomicsBenchmarking of mass spectrometry-based antibody repertoire profiling reveals extensive systematic biases
The serum antibody repertoire is crucial for long-term immune protection, holding significant immunological and biotechnological value. Bottom-up proteomics is the most widely used mass spectrometry (MS) technique for profiling the sequence diversity of serum antibodies. However, serum antibody bott...
ORGANISM(S): Homo sapiens (Human) 
2025-12-04 | PXD055846 | Pride
Serum antibody bottom-up proteomics (ab-seq) Ms Antibody sequencing Serum antibody repertoire 
ProteomicsTranscriptomic and proteomic insights into progressive myoclonus epilepsy, EPM1
Progressive myoclonus epilepsy EPM1 is a rare neurodegenerative disorder resulting from the partial loss of function of cystatin B (CSTB), a cysteine protease inhibitor with neuroprotective roles. The disease's mechanisms are not fully understood, and no treatments exist to manage the severe myoclon...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-27 | PXD068278 | Pride
Proteomics Brain Cstb-/- mouse Cystatin b Transcriptomics Epm1 
Sort   by:  
 Page size