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TranscriptomicsThe Small Molecule ISRIB Reverses the Effects of eIF2α Phosphorylation on Translation and Stress Granule Assembly
We recently identified ISRIB as a potent inhibitor of the integrated stress response (ISR). ISRIB renders cells resistant to the effects of eIF2α phosphorylation and enhances long-term memory in rodents (10.7554/eLife.00498). Here we show by genome-wide in vivo ribosome profiling that translation o...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-65778 | biostudies-arrayexpress
ProteomicsProximity-dependent biotinylation detects association between stress granule associated proteins and SARS coronavirus nonstructural protein 1
Severe acute respiratory syndrome coronavirus (SARS-CoV and SARS-CoV-2) nonstructural protein 1 (nsp1) is a critical viral protein that suppresses host gene expression by blocking the assembly of the ribosome on host messenger RNAs (mRNA). Using proximity-dependent biotinylation assay followed by pr...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025980 | Pride
Nsp1 Stress granule Sars-cov Sars-cov-2 Bioid2 
TranscriptomicsIdentification of the stress granule transcriptome via RNA-editing in bulk S2 cells, single S2 cells and in Drosophila neurons
Stress granules are phase separated assemblies formed around mRNAs that have now been identified after stress granule purification from cell culture. Here, we present a purification free method to detect stress granules RNAs in single cells and in tissues, including those displaying cell heterogenei...
ORGANISM(S): Drosophila melanogaster 
2021-05-30 | GSE175782 | GEO
ProteomicsIntegrated multi-omics reveals common properties underlying stress granule and P-body formation
Non-membrane-bound compartments such as mRNA processing bodies (PBs) and stress granules (SGs) play important roles in the regulation of gene expression following environmental stresses. We have systematically determined the protein and mRNA composition of PBs and SGs formed in response to a common ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-11-03 | PXD018762 | Pride
Stress granule purification P-body purification Saccharomyces cerevisiae 
ProteomicsRoles of stress granule formation in cancer cell behaviors
Although several studies have reported that overexpression of certain SG proteins can enhance cancer progression, the role of SGs, per se, in this process has not been clearly determined. To address this issue, we expressed wild-type (EGFP-G3BP1) or mutant G3BP1 (EGFP-G3BP1-ΔNTF2, which lacks the G...
ORGANISM(S): Homo sapiens (Human) 
2025-09-17 | PXD058141 | Pride
Anchorage independence Anoikis stress Cancer progression Stress granule 
ProteomicsTM4SF1-AS1 inhibits apoptosis by promoting stress granule formation in cancer cells
Long noncoding RNAs (lncRNAs) play pivotal roles in tumor development, but little is known about their involvement in the early steps of tumorigenesis. To identify lncRNAs dysregulated in precancerous lesions, we analyzed genome-wide trimethylation of histone H3 lysine 4 (H3K4me3) to screen for tran...
ORGANISM(S): Homo Sapiens (human) 
2023-09-16 | PXD036766 | JPOST Repository
GenomicsIdentification of the stress granule transcriptome via RNA-editing in bulk S2 cells, single S2 cells and in Drosophila neurons
Identification of the stress granule transcriptome via RNA-editing in bulk S2 cells, single S2 cells and in Drosophila neurons
PRJNA733657 | ENA
ProteomicsProtein and metabolite composition of Arabidopsis stress granules
• Stress granules (SGs) are evolutionary conserved aggregates of proteins and untranslated mRNAs formed in response to stress. Despite their importance for stress adaptation, no complete proteome composition has been reported for plant SGs. Herein, we addressed the existing gap. Importantly, we also...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-01-07 | PXD011716 | Pride
Cdka1 Arabidopsis thaliana Stress granules proteome Stress response Stress granule metabolome Affinity purification Stress granule extraction 
ProteomicsBLM helicase protein negatively regulates stress granule formation through unwinding RNA G-quadruplex structures
Bloom’s syndrome (BLM) protein is a known nuclear helicase that is able to unwind DNA secondary structures such as G-quadruplexes. However, its role in the regulation of cytoplasmic processes that involve RNA G-quadruplexes (rG4s) has not been previously studied. Here, we demonstrate that BLM is rec...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD039534 | Pride
Stress granule Apex Helicase Lc-msms G-quadruplex Rg4-binding proteins Blm Quma-1 
ProteomicsFasnall induces atpically transient Stress Granules
Stress Granule formation has been linked to the resistance of some cancer cells to chemotherapeutic intervention. A number of studies have proposed that certain anti-tumor compounds promote cancer cell survival by inducing Stress Granules formation, leading to increased cellular fitness and apoptosi...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021229 | Pride
Stress granule Fasnall Pabpc1 
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