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ProteomicsCell Surface Engineering Enables Surfaceome Profiling
Understanding which proteins are presented at the cell surface is essential for ongoing therapeutic development, and to expand our basic understanding of biology. We envisioned the integration of cell surface engineering with radical-mediated protein biotinylation to profile cell surface proteins (C...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-05-06 | PXD031845 | Pride
Proximity labeling Surfaceome Pdac 
TranscriptomicsSurface sensing in Vibrio parahaemolyticus triggers a programme of gene expression that promotes colonization and virulence
Vibrio parahaemolyticus senses surfaces via impeded rotation of its polar flagellum. We have exploited this surface-sensing mechanism to trick the organism into thinking it is on a surface when it is growing in liquid. This facilitated studies of global gene expression in a way that avoided many of ...
ORGANISM(S): Vibrio parahaemolyticus 
2010-12-15 | E-GEOD-18763 | biostudies-arrayexpress
ProteomicsMetal organic layers enabled cell surface engineering coupling biomembrane fusion for dynamic membrane proteome profiling
Systematically dissecting the highly dynamic and tightly communicating membrane proteome of living cells is essential for systems-level understanding of fundamental cellular processes and intricate relationship between membrane-bound organelles constructed through membrane traffic. While extensive e...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD044945 | Pride
Membrane protein enrichment metal organic layers proteome 
ProteomicsMycobacterium tuberculosis surface proteomics
Surface shaving Mtb using two concentrations of trypsin: 0.4 ug/mL and 0.05 ug/mL. Both bacteria and supernatant without the bacteria were subject to trypsinization, to allow for a ratio between samples to identify candidate surface proteins.
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2024-12-11 | PXD052936 | Pride
Surface Proteomics Mtb 
TranscriptomicsSurface topography enhances differentiation of mesenchymal stem cells towards osteogenic and adipogenic lineages
Surface topography impacts on cell growth and differentiation, but it is not trivial to generate defined surface structures and to assess the relevance of specific topographic parameters. In this study, we have systematically compared in vitro differentiation of mesenchymal stem cells (MSCs) on a va...
ORGANISM(S): Homo sapiens 
2018-09-20 | E-MTAB-7177 | biostudies-arrayexpress
TranscriptomicsSurface Topography Enhances Differentiation of Mesenchymal Stem Cells Towards Osteogenic and Adipogenic Lineages
Surface topography impacts on cell growth and differentiation, but it is not trivial to generate homogeneous surface structures and to define the specific morphological parameters of relevance. In this study, we have compared gene expression profiles of mesenchymal stem cells (MSCs) on nanostructure...
ORGANISM(S): Homo sapiens 
2015-08-25 | E-GEOD-61113 | biostudies-arrayexpress
TranscriptomicsDynamic adaptation of mesenchymal stem cell physiology upon exposure to surface micropatterns
Human mesenchymal stem cells (hMSCs) are defined as multi-potent colony-forming cells expressing a specific subset of plasma membrane markers when grown on flat tissue culture polystyrene. However, as soon as hMSCs are used for transplantation, they are exposed to a 3D environment, which can strongl...
ORGANISM(S): Homo sapiens 
2019-06-18 | E-MTAB-7505 | biostudies-arrayexpress
ProteomicsRepurposing E3 ubiquitin ligases as cell surface protein degraders using Proteolysis Targeting Antibodies
The majority of current therapeutics targeting plasma membrane receptors function by antagonizing ligand binding or enzymatic activities. Typical mammalian proteins, however, consist of multiple domains executing discrete but coordinated activities, and saturating inhibition of one functional domain...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-05-25 | MSV000089542 | MassIVE
TranscriptomicsP. falciparum Complicated Malaria: Modulation and Connectivity between Exportome and Variant Surface Gene Families
In temperate and sub-tropical regions of Latin America, complicated malaria manifested as hepatic dysfunction or renal dysfunction is seen in all age groups. There has been a concerted focus on understanding the patho-physiological and molecular basis of complicated malaria in children, much less is...
ORGANISM(S): Plasmodium falciparum 
2015-07-07 | E-GEOD-59844 | biostudies-arrayexpress
TranscriptomicsPredicting the therapeutic efficacy of MSC in bone tissue engineering using the molecular marker CADM1
Mesenchymal stromal cells (hMSCs) are advancing into the clinic but the therapeutic efficacy of hMSCs faces the problem of donor variability. In bone tissue engineering, no reliable markers have been identified which are able to predict the bone-forming capacity of hMSCs prior to implantation. To th...
ORGANISM(S): Homo sapiens 
2018-10-04 | E-MTAB-7210 | biostudies-arrayexpress
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