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MetabolomicsDifferent regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly
Vesicle associated membrane protein 2 (VAMP2/synaptobrevin2), a core SNARE protein residing on synaptic vesicles (SVs), forms helix bundles with syntaxin-1 and SNAP25 for the SNARE assembly. Prior to the SNARE assembly, the structure of VAMP2 is unclear. Here, by using in-cell NMR spectroscopy, we d...
2021-10-06 | MTBLS1503 | MetaboLights
ProteomicsCross-linking mass spectrometry uncovers protein interactions and functional assemblies in synaptic vesicle membranes
Synaptic vesicles are storage organelles for neurotransmitters in the pre-synaptic cytosol. When an action potential arrives at the pre-synaptic terminal, they fuse with the pre-synaptic membrane and neurotransmitters are released. In this project, we set out to study the protein interactions formed...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-12-09 | PXD020859 | Pride
Chemical cross-linking Mass spectrometry Protein networks Synaptic vesicles Synaptophysin Synaptobrevin-2 
TranscriptomicsTranscriptional dysregulation of synaptic genes in a human iPSC model of major mental disorders
Schizophrenia and other psychiatric disorders are postulated to be developmental disorders resulting from synapse dysfunction. How susceptibility genes for major mental disorders could lead to synaptic deficits in humans is not well-understood. Here we generated induced pluripotent stem cells (iPSCs...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-57821 | biostudies-arrayexpress
ProteomicsSynaptic vesicle proteomics with age and in synucleinopathies
Neurotransmitter release occurs through exocytosis of synaptic vesicles. α-Synuclein’s function and dysfunction in Parkinson’s disease and other synucleinopathies is tightly linked to synaptic vesicle binding. Age is the biggest risk factor for synucleinopathy, and ~15% of synaptic vesicle proteins ...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-02 | PXD048771 | Pride
Synuclein Synaptic vesicle Mouse Age 
UnknownClathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity.
Not available
S-EPMC5935483 | biostudies-literature
ProteomicsBeta-synuclein potentiates synaptic vesicle dopamine uptake and rescues dopaminergic neurons from MPTP-induced death in the absence of other synucleins
Previous studies have demonstrated an importance of alpha-synuclein as a modulator of various mechanisms implicated in chemical neurotransmission but information about other two synuclein family members’ involvement in molecular processes taking place in presynaptic terminals is limited. Here we dem...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD027786 | Pride
Dopamine Synapse Mptp toxicity Synuclein Transgenic mice Dopaminergic neurons Parkinson’s disease Vesicles Neurodegenerative disease Neurotransmitter vesicular uptake 
UnknownHigh- and low-mobility stages in the synaptic vesicle cycle.
Not available
S-EPMC2905121 | biostudies-literature
ProteomicsControl of synaptic vesicle release probability via VAMP4 targeting to endolysosomes
The probability of synaptic vesicle (SV) fusion in response to an action potential, termed vesicular release probability (Pr), is a stochastic but tightly regulated process. SNARE proteins are the molecular executors of SV fusion and therefore, key modulators of Pr. The non-canonical SNARE VAMP4 is ...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-11 | PXD021437 | Pride
Endosome Neurotransmitter Synaptic plasticity Release probability Vamp4 Lysosome Synaptic vesicle Endocytosis 
ProteomicsIdentification of synaptic DGKq interactors that stimulate DGKq activity
Lipids and their metabolic enzymes are a critical point of regulation for the membrane curvature required to induce membrane fusion during synaptic vesicle recycling. One such enzyme is diacylglycerol kinase theta (DGKq), which produces phosphatidic acid (PtdOH) that generates negative membrane curv...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-12-18 | PXD030495 | Pride
Lc-msms Apex2 Dgk Syt1 
UnknownEndophilin-A regulates presynaptic Ca2+ influx and synaptic vesicle recycling in auditory hair cells.
Not available
S-EPMC6396150 | biostudies-literature
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