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UnknownPolymer film-based microwell array platform for long-term culture and research of human bronchial organoids.
The culture of lung organoids relies on drops of basement membrane matrices. This comes with limitations, for example, concerning the microscopic monitoring and imaging of the organoids in the drops. Also, the culture technique is not easily compatible with micromanipulations of the organoids. In th...
S-EPMC10060184 | biostudies-literature
UnknownThe pattern of gene copy number alteration (CNAs) in hepatocellular carcinoma: an in silico analysis.

Background

Hepatocellular carcinoma (HCC) is the most common type of liver cancer that occurs predominantly in patients with previous liver conditions. In the absence of an ideal screening modality, HCC is usually diagnosed at an advanced stage. Recent studies show that loss or gain of genom...
S-EPMC8254242 | biostudies-literature
UnknownCalcium Phosphate-Coated and Strontium-Incorporated Mesoporous Silica Nanoparticles Can Effectively Induce Osteogenic Stem Cell Differentiation.
Ceramic (nano)materials are promising materials for bone regeneration applications. The addition of bioinorganics such as strontium (Sr) and zinc (Zn) is a popular approach to further improve their biological performance. However, control over ion delivery is important to prevent off-target effects....
S-EPMC11468810 | biostudies-literature
UnknownTranscript-Activated Coatings on Titanium Mediate Cellular Osteogenesis for Enhanced Osteointegration.
Osteointegration is one of the most important factors for implant success. Several biomolecules have been used as part of drug delivery systems to improve implant integration into the surrounding bone tissue. Chemically modified mRNA (cmRNA) is a new form of therapeutic that has been used to induce ...
S-EPMC7927143 | biostudies-literature
UnknownComparative proteomic analysis of human mesenchymal stromal cell behavior on calcium phosphate ceramics with different osteoinductive potential.
In recent years, synthetic calcium phosphate (CaP) ceramics have emerged as an alternative to bone grafts in the treatment of large critical-sized bone defects. To successfully substitute for bone grafts, materials must be osteoinductive, that is, they must induce osteogenic differentiation and subs...
S-EPMC7334494 | biostudies-literature
UnknownMicrofluidically Aligned Collagen to Maintain the Phenotype of Tenocytes In Vitro.
Tendon is a highly organized tissue that transmits forces between muscle and bone. The architecture of the extracellular matrix of tendon, predominantly from collagen type I, is important for maintaining tenocyte phenotype and function. Therefore, in repair and regeneration of damaged and diseased t...
S-EPMC11468977 | biostudies-literature
UnknownEnthesitis on Chip - A Model for Studying Acute and Chronic Inflammation of the Enthesis and its Pharmacological Treatment.
Enthesitis, the inflammation of the enthesis, which is the point of attachment of tendons and ligaments to bones, is a common musculoskeletal disease. The inflammation often originates from the fibrocartilage region of the enthesis as a consequence of mechanical overuse or -load and consequently tis...
S-EPMC11650547 | biostudies-literature
UnknownAn in vitro model system based on calcium- and phosphate ion-induced hMSC spheroid mineralization.
A challenge in regenerative medicine is creating the three-dimensional organic and inorganic in vitro microenvironment of bone, which would allow the study of musculoskeletal disorders and the generation of building blocks for bone regeneration. This study presents a microwell-based platform ...
S-EPMC10682137 | biostudies-literature
UnknownOptimization of a tunable process for rapid production of calcium phosphate microparticles using a droplet-based microfluidic platform.
Calcium phosphate (CaP) biomaterials are amongst the most widely used synthetic bone graft substitutes, owing to their chemical similarities to the mineral part of bone matrix and off-the-shelf availability. However, their ability to regenerate bone in critical-sized bone defects has remained inferi...
S-EPMC11004461 | biostudies-literature
UnknownReal-Time Monitoring of the Formation and Culture of Hybrid Cell-Microbiomaterial Spheroids Using Non-Faradaic Electrical Impedance Spectroscopy.
Cellular spheroids are considered a popular option for modeling healthy and diseased tissues in vitro and as injectable therapies. The formation and culture of spheroids can make use of different three-dimensional (3D) culture platforms, but the spheroids' analysis often has to rely on endpoi...
S-EPMC12522083 | biostudies-literature
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