Sort   by:  
 Page size 
ProteomicsASCL1: a pioneer factor that induces subtype switching and characterizes adrenergic neuroblastoma
Neuroblastoma is an embryonic malignancy originating from early nerve cells. Neuroblastoma retains plasticity, interconverting between the mesenchymal (MES) and adrenergic (ADRN) states, which are controlled by different sets of transcription factors forming the core regulatory circuit (CRC). Howeve...
ORGANISM(S): Homo sapiens (Human) 
2023-12-08 | PXD037670 | Pride
Ascl1 Subtype switching Neuroblastoma Pioneer factor Core regulatory circuit 
ProteomicsGlobal analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesis
In addition to genomic alterations, aberrant changes in post-transcriptional regulation can modify gene function and drive cancer development. RNA-binding proteins (RBPs) are a large class of post-transcriptional regulators that have been increasingly implicated in carcinogenesis. By integrating mul...
ORGANISM(S): Homo sapiens (Human) 
2022-03-10 | PXD030215 | Pride
Post-transcriptional regulation Larp1 Myc Rna-binding protein Cancer 
ProteomicsLong-read transcriptome sequencing reveals abundant promoter diversity in distinct molecular subtypes of gastric cancer
Deregulated gene expression is a hallmark of cancer, however most studies to date have analyzed short-read RNA-sequencing data with inherent limitations. Here, we combine PacBio long-read isoform sequencing (Iso-Seq) and Illumina paired-end short read RNA sequencing to comprehensively survey the tra...
ORGANISM(S): Homo sapiens (Human) 
2021-02-02 | PXD023373 | Pride
Isoform sequencing (iso-seq) Alternative promoters Gastric cancer Long-read sequencing 
ProteomicsPLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP production
Inhibitors of the mitotic kinase PLK1 yield objective responses in a subset of refractory cancers. However, PLK1 overexpression in cancer does not correlate with drug sensitivity, and the clinical development of PLK1 inhibitors has been hampered by the lack of patient selection marker. Using a high-...
ORGANISM(S): Homo sapiens (Human) 
2022-03-08 | PXD031110 | Pride
Oxidative phosphorylation Mitochondria Plk1 Arid1a Synthetic lethality 
UnknownFactors associated with D-dimer levels in HIV-infected individuals.
Not available
S-EPMC3953205 | biostudies-literature
ProteomicsLong non-coding RNA PLUM controls PRC2-mediated H3K27 methylation in multiple myeloma to promote chemoresistance
Multiple myeloma (MM) ranks the second most prevalent haematological malignancy globally. Despite advancements in managing MM, it remains incurable due to the high genetic heterogeneity leading to treatment resistance and disease severity. One key drug resistance associated signalling pathway often ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-23 | PXD054586 | Pride
Non-coding rna Prc2 Plum Ezh2 Multiple myeloma Chemoresistance 
ProteomicsThe H. pylori CagA Oncoprotein Induces DNA Double Strand Breaks Through Fanconi Anemia Pathway Downregulation and Replication Fork Collapse
The proteins from the Fanconi Anemia (FA) pathway of DNA repair maintain DNA replication fork integrity by preventing the unscheduled degradation of nascent DNA at regions of stalled replication forks. Here, we ask if the bacterial pathogen H. pylori exploits the fork stabilisation machinery to gene...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD031168 | Pride
H. pylori  dna replication  caga  dna double strand breaks  fanconi anemia  h2ax 
Proteomicsc-Met activation leads to the establishment of a TGFβ receptor regulatory network required for bladder cancer invasion
Treatment of muscle-invasive bladder cancer remains a major clinical challenge. Aberrant HGF/c-MET upregulation and activation is frequently observed in bladder cancer correlating with cancer progression and invasion. However, the precise mechanisms underlying HGF/c-MET mediated invasion in bladder ...
ORGANISM(S): Homo sapiens (Human) 
2019-08-26 | PXD014736 | Pride
C-met Emt Bladder cancer invasion Phosphorylation Tgfb Smurf2 
ProteomicsSecretory autophagy mediates mitochondria clearance in the absence of the mATG8-conjugation machinery
PINK1-Parkin mediated mitophagy, a selective form of autophagy, represents an important mechanism in mitochondrial quality control (MQC) via clearance of damaged mitochondria. Although it is well known that the conjugation of mammalian ATG8s to phosphatidylethanolamine (PE) is a key step in autophag...
ORGANISM(S): Homo sapiens (Human) 
2022-06-03 | PXD025356 | Pride
Mitochondria Autophagy 
ProteomicsqChIP-MS reveals the local chromatin composition by label-free quantitative proteomics
Chromatin immunoprecipitation (ChIP) has been a cornerstone for epigenetic analyses over the last decades, but even coupled to sequencing approaches (ChIP-seq), it is ultimately limited to one protein at a time. In a complementary effort, we here combine ChIP with label-free quantitative mass spectr...
ORGANISM(S): Homo sapiens (Human) 
2026-04-03 | PXD076520 | Pride
Sort   by:  
 Page size