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ProteomicsDeep proteomic and phosphoproteomic profiling of neuroblastoma treated with XPO1 inhibitor Selinexor
Neuroblastoma accounts for 15% of cancer-related deaths in children, highlighting an unmet need for novel therapies. Selinexor is a small molecule inhibitor of XPO1 that shuffles cargo proteins with a nuclear export sequence, many of which are essential for cancer growth and cell maintenance, from t...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD026454 | Pride
Tmtpro Phosphoproteome Selinexor Xpo1 Neuroblastoma Proteome 
ProteomicsProteome profiling of mouse germinal center B cells
Productive B cell responses are critical to protect a host from infection. The spleen and lymph nodes are populated by resting follicular B cells, which can enter germinal centers upon antigen encounter. Once in the germinal center, B cells migrate between the dark and light zones, where they underg...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-06 | PXD015524 | Pride
Mouse B cells 
ProteomicsIdentification of lysine succinylome and acetylome in vancomycin-intermediate Staphylococcus aureus XN108
In this study, we detected the first lysine succinylome and acetylome in a vancomycin-intermediate S. aureus (VISA) strain, XN108.Furthermore,Comparative analysis of the protein succinylation and acetylation between XN108-ΔcobB and XN108-WT strain was conducted on the basis of quantitative detection...
ORGANISM(S): Staphylococcus aureus 
2022-11-09 | PXD033341 | Pride
Post-translational modification  staphylococcus aureus visa  succinylation  acetylation sacobb. 
ProteomicsGlobal Proteomic Profiling of Pediatric AML: A Pilot Study
Acute Myeloid Leukemia (AML) is a heterogeneous disease with several recurrent cytogenetic abnormalities. Despite genomics and transcriptomics profiling efforts to understand AML’s heterogeneity, studies focused on the proteomic profiles associated with pediatric AML cytogenetic features remain limi...
ORGANISM(S): Homo sapiens (Human) 
2023-09-26 | PXD043982 | Pride
Leukemic cells Pediatrics acute myeloid leukemia Transcriptomics Tandem mass tag Untargeted labeled proteomics 
MetabolomicsPu-erh tea and theabrownin ameliorate metabolic syndrome in mice via potential microbiota-gut-liver-brain interactions
Metabolic syndrome (MS) is a common metabolic disorder characterized by obesity, insulin resistance, cardiovascular disease and gut microbiota dysbiosis. Pu-erh tea and its ingredient theabrownin have known functions on the reduction of body weight gain and fat accumulation. However, few studies sys...
2024-09-25 | MTBLS2594 | MetaboLights
ProteomicsAcute depletion of CTCF rewires genome-wide chromatin accessibility
The transcription factor CTCF appears indispensable in defining topologically associated domain boundaries and maintaining chromatin loop structures within these domains, supported by numerous functional studies. However, acute depletion of CTCF globally reduces chromatin interactions but does not s...
ORGANISM(S): Homo sapiens (Human) 
2021-07-04 | PXD026484 | Pride
Multiomics Phosphoproteome Ctcf Proteome 
UnknownLysSYL-Loaded pH-Switchable Self-Assembling Peptide Hydrogels Promote Methicillin-Resistant Staphylococcus Aureus Elimination and Wound Healing.
Not available
S-EPMC11681319 | biostudies-literature
ProteomicsIntegrated proteomics reveals autophagy degradation landscape in neurons and receptors regulating neuronal activity
Autophagy is a constitutive process of lysosomal degradation required for maintaining the homeostasis of large molecular complexes and organelles in neurons. Here we reported a systemic investigation of neuronal autophagy targets through integrated proteomics and functional analysis. Proteomic profi...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-06-22 | PXD048730 | Pride
Mass spectrometry Neuron Autophagy degradation Integrated proteomics Tandem mass tag Lc-ms/ms 
ProteomicsDeep undepleted human serum proteome profiling toward biomarker discovery for Alzheimer’s disease
Alzheimer's disease (AD) is a neurodegenerative disease, the most common cause of dementia in elderly persons. Accumulation of amyloid plaques in the brain is a characteristic of AD. The requirements for a biomarker include the ability to measure a pathologic process, predict outcome, distinguish di...
ORGANISM(S): Homo sapiens (Human) 
2019-04-23 | PXD011482 | Pride
Proteomics Alzheimer’s disease Human blood Mass spectrometry Plasma Serum Proteome Tandem mass tag Biomarker 
ProteomicsIntegrative proteomics and phosphoproteomics profiling and systems biology analysis reveal dynamic signaling networks and mTORC1-dependent mitochondrial function in T cell activation
The underlying mechanisms by which naïve T cells exit from quiescence after antigen stimulation remain elusive. Using multiplex isobaric labeling proteomics technology, we report unbiased, temporal profiling of whole proteome (>8,000 proteins) and phosphoproteome (>13,000 phosphopeptides) during the...
ORGANISM(S): Mus musculus (Mouse) 
2017-03-15 | PXD004367 | Pride
System biology T cell activation Mtorc1 Mass spectrometry Rptor Proteomic Phosphoproteomics Mitochondrial function 
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