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TranscriptomicsFundamental differences in promoter CpG island DNA hypermethylation between human cancer and genetically engineered mouse models of cancer [Methylation profiling by array]
Genetic and epigenetic alterations are essential for the initiation and progression of human cancer. We previously reported that primary human medulloblastomas showed extensive cancer-specific CpG island DNA hypermethylation in critical developmental pathways. To determine whether genetically engine...
ORGANISM(S): Homo sapiens 
2013-10-10 | E-GEOD-45240 | biostudies-arrayexpress
ProteomicsLC-MS of FLAG-tagged C-terminal domain of human DUX4
DUX4 activates the first wave of zygotic gene expression in the early embryo. Mis-expression of DUX4 in skeletal muscle causes facioscapulohumeral dystrophy (FSHD), whereas expression in cancers suppresses IFNg-induction of MHC Class I and contributes to immune evasion. We show that the DUX4 protein...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD029215 | Pride
Interferon gamma Cgas Dux Interferon beta Rig-i Dux4 Mda5 Stat1 Duxc Interferon stimulated genes 
ProteomicsNuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins
This study was designed to identify proteins associated with the D4Z4 macrosatellite repeat array in human muscle cells using a locus-specific proteomics approach (enChIP-MS).
ORGANISM(S): Homo sapiens (Human) 
2018-03-02 | PXD006839 | Pride
D4z4 Human Fshd Dux4 
TranscriptomicsDUX4-induced gene expression is the major molecular signature in FSHD skeletal muscle
Facioscapulohumeral dystrophy (FSHD) is caused by decreased epigenetic repression of the D4Z4 macrosatellite array and recent studies have shown that this results in the expression of low levels of the DUX4 mRNA in skeletal muscle. Several other mechanisms have been suggested for FSHD pathophysiolog...
ORGANISM(S): Homo sapiens 
2014-07-03 | E-GEOD-56787 | biostudies-arrayexpress
GenomicsFundamental differences in promoter CpG island DNA hypermethylation between human cancer and genetically engineered mouse models of cancer [RRBS]
Genetic and epigenetic alterations are essential for the initiation and progression of human cancer. We previously reported that primary human medulloblastomas showed extensive cancer-specific CpG island DNA hypermethylation in critical developmental pathways. To determine whether genetically engine...
ORGANISM(S): Mus musculus 
2013-10-10 | E-GEOD-45341 | biostudies-arrayexpress
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