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ProteomicsHuman SKI component SKIV2L regulates telomeric DNA-RNA hybrids and prevents telomere fragility
Super killer (SKI) complex is a well-known cytoplasmic 3′ to 5′ mRNA decay complex that functions with the exosome to degrade excessive and aberrant mRNAs. Recently, SKIV2L, the 3′ to 5′ RNA helicase of the human SKI (hSKI) complex has been implicated with the extraction of mRNA at stalled ribosomes...
ORGANISM(S): Homo sapiens (Human) 
2024-10-03 | PXD046955 | Pride
Skiv2l Genome instability Dna-rna hybrids Dna damage Telomere 
ProteomicsThe Human Telomeric Proteome During Telomere Replication
Telomere shortening can cause detrimental diseases and contribute to aging. It occurs due to the end replication problem in cells lacking telomerase. In addition, recent evidence revealed that telomere shortening can be attributed to difficulties of the semi-conservative DNA replication machinery to...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD018712 | Pride
Pot1 Telomeres Ipond Telomere fragility Histone h1 Qtip Dna replication 
ProteomicsDNA2 and MSH2 activities collectively mediate environmental chemical compound stabilized G4 for efficient telomere replication
G-quadruplexes (G4s) are widely existing stable DNA secondary structures in mammalian cells. A long-standing hypothesis is that timely resolution of G4s is needed for efficient and faithful DNA replication. In vitro, G4s may be unwound by helicases or alternatively resolved via DNA2 nuclease-mediate...
ORGANISM(S): Homo sapiens (Human) 
2025-08-07 | PXD059843 | Pride
G-quadruplex Msh2 Dna2 Telomere 
UnknownHuman SKI component SKIV2L regulates telomeric DNA-RNA hybrids and prevents telomere fragility.
Not available
S-EPMC11530851 | biostudies-literature
TranscriptomicsRoles of mammalian Rap1 in TERT recruitment to chromatin, subtelomeric gene silencing and transcriptional regulation
Repressor-activator protein 1 (scRap1) is the major binding activity at Saccharomyces cerevisiae telomeres, with roles in telomere length regulation and establishment of subtelomeric silencing by recruiting the Sir proteins. scRap1 also acts as a transcription factor controlling the expression of ri...
ORGANISM(S): Mus musculus 
2010-07-10 | E-GEOD-19011 | biostudies-arrayexpress
UnknownTopoIIα prevents telomere fragility and formation of ultra thin DNA bridges during mitosis through TRF1-dependent binding to telomeres.
Not available
S-EPMC4050144 | biostudies-literature
UnknownBRCA2 acts as a RAD51 loader to facilitate telomere replication and capping.
Not available
S-EPMC2998174 | biostudies-literature
UnknownTPP1 is required for TERT recruitment, telomere elongation during nuclear reprogramming, and normal skin development in mice.
Not available
S-EPMC3631760 | biostudies-literature
UnknownMammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites.
Not available
S-EPMC3792482 | biostudies-literature
UnknownThe THO complex counteracts TERRA R-loop-mediated telomere fragility in telomerase+ cells and telomeric recombination in ALT+ cells.
Not available
S-EPMC10359610 | biostudies-literature
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