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ProteomicsScandiumIII
Recently, it has been reported that some metal complexes can act as artificial proteases. In particular, the Lewis acid scandium(III) triflate has been shown to catalyze the cleavage of peptide bonds N- and C-terminal to serine and threonine residues. Therefore, we investigated if this compound can ...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Equus caballus (Horse) 
2020-05-26 | PXD014918 | Pride
Endoproteinase Protein cleavage Mass spectrometry Scandium(iii) triflate Lewis acid 
ProteomicsLarge scale intact glycopeptide identification by Mascot database search
We present the adaptability of Mascot search engine for automated identification of intact glycopeptide mass spectra. The steps involved in adopting Mascot for intact glycopeptide analysis include: i) assigning unique one letter codes for monosaccharides, ii) linearizing glycan sequences and iii) pr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-07-02 | MSV000082567 | MassIVE
TranscriptomicsTranscription profiling of human CD34+ hematopoietic cells grown in suspension culture or in a collegen I matrix
CD34+ hematopoietic stem/progenitor cells (HSC) reside in the bone marrow in close vicinity to the endosteal bone surface, surrounded by osteoblasts, stromal cells and various extracellular matrix molecules. We utilized a bioartificial matrix containing fibrillar collagen I, the major matrix compone...
ORGANISM(S): Homo sapiens 
2007-12-12 | E-GEOD-3003 | biostudies-arrayexpress
ProteomicsDiethylation
In this study we compared diethylation using acetaldehyde-13C2/13C1 and acetaldehyde-2H4/1H4. Light and heavy labeled samples were combined in a ratio of 1:1 and analyzed on a LC-MSMS system using an OrbitrapXL. We analyzed ten techical replicates of each labeling version (13C/12C and 2H/1H) and com...
ORGANISM(S): Homo sapiens (Human) 
2022-03-02 | PXD001256 | Pride
Diethylation Retention time shift Stable isotope labeling Reductive amination Orbitrapxl 
TranscriptomicsGene expression profiling in AML with normal karyotype: A multicenter study investigating molecular markers in 251 cases
Acute myeloid leukemia (AML) is a heterogeneous disease and AML with normal karyotype (AML-NK) is categorized as an intermediate-risk group. Over the past years molecular analyses successfully identified biomarkers that will further allow to dissecting clinically meaningful subgroups in this disease...
ORGANISM(S): Homo sapiens 
2009-12-31 | E-GEOD-15434 | biostudies-arrayexpress
TranscriptomicsDetection of transcription factor NRF1, YY1 and SP1 bound regions in human peripheral blood monocytes
To study the correlation between sequence motif appearance, transcription factor binding and aberrant hypermethylation in the cell lines, we performed ChIP-on-chip analyses (on CpG island microarrays) for the transcription factors Sp1, NRF1 and YY1 in normal peripheral blood monocytes. Keywords: Ch...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-16078 | biostudies-arrayexpress
ProteomicsNAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase. WS patients exhibit severe metabolic phenotypes, but the underlying mechanisms are not understood, and whether the metabolic def...
ORGANISM(S): Caenorhabditis elegans 
2020-01-13 | PXD015644 | Pride
Mitophagy Wrn Nad+ Nmnat1 Aging 
TranscriptomicsAutotaxin is expressed in FLT3-ITD positive acute myeloid leukemia and hematopoietic stem cells and promotes cell migration and proliferation
Autotaxin (ATX) has been reported to act as a motility and growth factor in a variety of cancer cells. The ATX protein acts as a secreted lysophospholipase D (lysoPLD) by converting lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), which signals via G-protein coupled receptors and has im...
ORGANISM(S): Homo sapiens 
2013-05-10 | E-MTAB-1169 | biostudies-arrayexpress
UnknownCharacteristics and outcome of patients with low-/intermediate-risk acute promyelocytic leukemia treated with arsenic trioxide: an international collaborative study.
Not available
S-EPMC8634174 | biostudies-literature
TranscriptomicsGenome wide analysis of Histone H3 acetylation patterns in AML identifies PRDX2 as an epigenetically silenced tumor suppressor gene
Epigenetic deregulation plays a critical role in the pathogenesis of Acute Myeloid Leukemia. But changes in histone modification patterns at the epigenome level still remain largely unknown. Here, we analyzed alterations of histone H3 acetylation patterns in a large number of patients with AML compa...
ORGANISM(S): Homo sapiens 
2011-12-16 | E-GEOD-27863 | biostudies-arrayexpress
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