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TranscriptomicsTranscription profiling of Drosophila wild type vs TIM-MJD mutants expressing a polyglutamine-expanded neurotoxic protein in the major timeless (tim)-expressing cells after 3 days of training in light-dark (LD) conditions
WT flies or flies of the strain Tim-gal4; UAS-MJD78Q. All samples were collected at ZT16 after 3 days of training in LD conditions.
ORGANISM(S): Drosophila melanogaster 
2008-06-12 | E-GEOD-2422 | biostudies-arrayexpress
ProteomicsA hybrid TIM complex mediates protein import into hydrogenosomes of Trichomonas vaginalis
Hydrogenosomes are a specific type of mitochondria that have adapted for life under anaerobiosis. Limited availability of oxygen has resulted in the loss of the membrane- associated respiratory chain, and consequently in the generation of minimal inner membrane potential (), and inefficient ATP synt...
ORGANISM(S): Trichomonas vaginalis 
2024-06-16 | PXD047649 | Pride
Presequence translocase-associated motor Parasite Protein import machinery Tim22 complex Mitochondria Tim23 complex Trichomonas vaginalis Hydrogenosomes 
ProteomicsGlycosite mapping and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE
Mucin-domain glycoproteins are densely O-glycosylated and play key roles in a host of biological functions. In particular, the T-cell immunoglobulin and mucin-domain containing family of proteins (TIM-1, 3, 4) decorate immune cells and act as key checkpoint inhibitors in cancer. However, their dense...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-09-27 | PXD039583 | Pride
O-glycoprotein Tim-1 Cancer Mucinase Tim-4 Tim-3 O-glycosylation Immune checkpoint T-cell immunoglobulin and mucin-domain containing Lc-ms/ms Molecular dynamics Mucinome Mucin O-glycoproteomics Mucin domain Checkpoint inhibitor O-glycoprotease 
TranscriptomicsExpression data from human lymphoma endothelium and reactive lymph node-derived endothelium
Angiogenesis plays a key role in tumor metastasis. Many genes may act in this process including formation of vessels, immune evasion,etc. Different gene expression profiles between lymphoma endothelium cells and reactive lymph node-derived endothelium cells may uncover these genes. And intensive mec...
ORGANISM(S): Homo sapiens 
2010-01-14 | E-GEOD-19882 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse B16-F10 melanoma cells stimulated with TIM-3
The effect of TIM-3 stimulation was studied on B16F10 mouse melanoma cells, in vitro. Experiment Overall Design: Cy3: B16F10 mouse melanoma cells, treated by unspecific goat IgG (control) for 2 hours. Experiment Overall Design: Cy5: B16F10 mouse melanoma cells, in vitro, treated by an agonist goat p...
ORGANISM(S): Mus musculus 
2009-10-15 | E-GEOD-14418 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse IgE/antigen-activated mast cells stimulated with TIM-3
TIM-3 is known to be expressed on dendritic cells, monocytes, melanoma cells, mast cells and on activated Th1 cells. In activated Th1 cells, stimulating TIM-3 by one of its ligands, galectin-9, leads to apoptosis and thus it plays a central role in terminating Th1-type immune responses. Interestingl...
ORGANISM(S): Mus musculus 
2009-10-15 | E-GEOD-14438 | biostudies-arrayexpress
UnknownKnock-down of the TIM/TIPIN complex promotes apoptosis in melanoma cells.
Not available
S-EPMC7244016 | biostudies-literature
UnknownHuman Tim-Tipin complex affects the biochemical properties of the replicative DNA helicase and DNA polymerases.
Not available
S-EPMC3574903 | biostudies-literature
UnknownThe human Tim-Tipin complex interacts directly with DNA polymerase epsilon and stimulates its synthetic activity.
Not available
S-EPMC3642320 | biostudies-literature
UnknownA hybrid TIM complex mediates protein import into hydrogenosomes of Trichomonas vaginalis.
Not available
S-EPMC11145794 | biostudies-literature
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