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MetabolomicsJasmonate-mediated stomatal closure under elevated CO2 revealed by time-resolved metabolomics
Foliar stomatal movements are critical for regulating plant water loss and gas exchange. Elevated carbon dioxide (CO2) levels are known to induce stomatal closure. However, the current knowledge on CO2 signal transduction in stomatal guard cells is limited. Here we report metabolomic responses of Br...
2017-04-25 | MTBLS312 | MetaboLights
ProteomicsTime-resolved combined analysis of transcriptome and proteome of the pathogenicity-activated plant pathogen Xanthomonas oryzae pv. oryzae
Xanthomonas oryzae pv. oryzae (Xoo) is a rice pathogen causing bacterial blight, which outbreaks in most rice cultivating countries and reduces yield up to 50% due to no effective pesticide. Urgent responses of Xoo upon the initial contacts with rice at infection site are essential for pathogenesis....
ORGANISM(S): Xanthomonas oryzae pv. oryzae KACC 10331 
2021-09-09 | PXD020135 | Pride
Transcriptome Time-resolved gene expression Xoo–rice interactions Pathogenicity Proteome Xanthomonas oryzae pv. oryzae 
ProteomicsA time-resolved multi-omics atlas of Acanthamoeba castellanii encystment
Encystment is a common response of most protists to stress. Although some signaling pathways regulating this process were reported, our knowledge remains limited. Here, we mapped the molecular changes occurring in the amoeba Acanthamoeba castellanii during the early steps of encystment. De novo anal...
ORGANISM(S): Acanthamoeba castellanii str. Neff 
2022-07-12 | PXD031788 | Pride
Acanthamoeba castellanii Encystment Time-resolved molecular atlas 
ProteomicsDecrypting drug actions and protein modifications by dose- and time-resolved chemical proteomics
Measuring dose-dependent effects of drugs on post-translational modifications on a proteome-wide scale reveals how these drugs work in cells. Here, we present a quantitative chemical proteomic approach termed decryptM, able to assess target and pathway engagement as well as the mode of action (MoA)...
ORGANISM(S): Homo sapiens (Human) 
2023-03-17 | PXD037285 | Pride
Kat Screen Drug mode of action Post-translational modifciation Time-resolved Inhibitors Decryptm Proteome-wide Hdac Dose-resolved Kinase 
ProteomicsThree rate-determining protein roles in photosyntheic O2-evolution addressed by time-resolved experiments on genetically modified photosystems
Light-driven water splitting by plants, algae and cyanobacteria is pivotal for global bioenergetics and biomass formation. A manganese cluster bound to the photosystem II proteins catalyzes the complex reaction at high rate, but the rate-determining factors are insufficiently understood. Here we tra...
ORGANISM(S): Synechocystis sp. PCC 6803 
2025-09-17 | PXD068038 | Pride
Time-resolved infrared spectroscopy Time-resolved polarography Molecular dynamics simulations Proton-coupled electron transfer Photosynthetic o2 formation 
UnknownTracking Pathogen Infections by Time-Resolved Chemical Proteomics.
Not available
S-EPMC8276254 | biostudies-literature
ProteomicsTime and compartment resolved proteome profiling of the extracellular niche in lung injury and repair
The extracellular niche is a key regulator of tissue morphogenesis and repair, however, its composition is currently not well characterized. Quantitative mass spectrometry resolved the dynamics of 8366 proteins from total tissue and bronchioalveolar lavage fluid in the consecutive phases of repair u...
ORGANISM(S): Mus musculus (Mouse) 
2015-07-21 | PXD001765 | Pride
Regeneration Proteomics Matrisome Fibrosis Repair 
ProteomicsTime-Resolved Interactome Profiling Deconvolutes Secretory Protein Quality Control Dynamics
Protein-protein interactions play host to several cellular processes that depend heavily on both spatial and temporal regulation of these interactions. As such, understanding these parameters is necessary to fully comprehend and elucidate cellular processes and pathological disease states associated...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2024-08-08 | PXD035681 | Pride
Time-resolved proteomics  protein quality control  mass spectrometry  affinity purification - mass spectrometry 
ProteomicsDistinct phases of cellular signaling revealed by time-resolved protein synthesis
The post-translational regulation of protein function is involved in most cellular processes. As such, synthetic biology tools that operate at this level provide opportunities for manipulating cellular states. Here, we deploy a proximity-triggered protein trans-splicing technology to enable the time...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-10-06 | PXD044530 | Pride
Signaling Silac ap-ms Protein engineering Prm Tmt-phosphoproteomics Fusion oncogenes 
GenomicsCombining Time-Resolved Transcriptomics and Proteomics Data for Adverse Outcome Pathway Refinement in Ecotoxicology
Combining Time-Resolved Transcriptomics and Proteomics Data for Adverse Outcome Pathway Refinement in Ecotoxicology
PRJNA910102 | ENA
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