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ProteomicsTMTpro16plex Isobaric Labeling Reagents: Attaining New Sample Multiplexing Heights and New Cellular Proteome Depths in Quantitative Proteomics
Isobaric labeling empowers proteome-wide expression measurements simultaneously across multiple samples. Here, an expanded set of 16 isobaric reagents based on a proline backbone (TMTpro) is presented. These reagents have similar characteristics to existing TMT reagents but with increased fragmentat...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD014369 | Pride
Tmtpro16plex Real-time search Quantitative proteomics 
ProteomicsTMTpro16plex Isobaric Labeling Reagents: Attaining New Sample Multiplexing Heights and New Cellular Proteome Depths in Quantitative Proteomics
Isobaric labeling empowers proteome-wide expression measurements simultaneously across multiple samples. Here, an expanded set of 16 isobaric reagents based on a proline backbone (TMTpro) is presented. These reagents have similar characteristics to existing TMT reagents but with increased fragmentat...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD016491 | Pride
Tmtpro16 
ProteomicsTMTpro16plex Isobaric Labeling Reagents: Attaining New Sample Multiplexing Heights and New Cellular Proteome Depths in Quantitative Proteomics
Isobaric labeling empowers proteome-wide expression measurements simultaneously across multiple samples. Here, an expanded set of 16 isobaric reagents based on a proline backbone (TMTpro) is presented. These reagents have similar characteristics to existing TMT reagents but with increased fragmentat...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD016940 | Pride
Human Tmtpro Proteomics Sps-ms3 Cell lines 
ProteomicsPost-transcriptional mechanisms modulate the consequences of adaptive copy number variation
Copy-number variants (CNVs) are large-scale amplifications or deletions of DNA that can drive rapid adaptive evolution and result in large-scale changes in gene expression. Whereas alterations in the copy number of one or more genes within a CNV can confer a selective advantage, other genes within a...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-11-01 | PXD046587 | Pride
Long-term experimental evolution (ltee) Glutamine-limited growth media Copy-number variant (cnv) Saccharomyces cerevisiae Orbitrap 
ProteomicsIdentification of non-conventional small molecule degraders and stabilizers of squalene synthase
The dataset was obtained by performing a TMTpro16plex expression proteomics experiment, where HeLa cells were treated with small molecule ligands of squalene synthase (FDFT1). The experiment was successful in re-producing previously obtained Western Blot results in regards to SQS (=FDFT1) levels and...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-06-07 | MSV000092115 | MassIVE
ProteomicsIdentification of non-conventional small molecule degraders and stabilizers of squalene synthase
The dataset was obtained by performing a TMTpro16plex expression proteomics experiment, where HeLa cells were treated with small molecule ligands of squalene synthase (FDFT1). The experiment was successful in re-producing previously obtained Western Blot results in regards to SQS (=FDFT1) levels and...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-10-18 | MSV000093137 | MassIVE
ProteomicsQuantitative analysis of tyrosine phosphorylation from FFPE tissues reveals patient specific signaling networks
The aim of this study was to characterize tyrosine phosphorylation from FFPE tissues. Global phosphoproteomics, global proteomics and tyrosine phosphorylation were measured using quantitative LC-MS/MS based on TMT labeling.
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020284 | Pride
Lc-ms/ms Phosphotyrosine Ffpe Afatinib 
ProteomicsSex Differences in Response to Glutathione Precursors in the Aging Heart
Diastolic dysfunction in the aged population is multifactorial. Common features of the aging heart are dysregulated metabolism, elevated oxidative stress, inflammation and fibrosis, where each of these conditions can linked together and further promote the altered phenotype. It becomes increasingly ...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-05 | PXD048895 | Pride
Heart Sex differences Mitochondria Aging Extracellular matrix 
ProteomicsSrc Family Kinases as potential therapeutic targets for chemotherapy-resistant triple negative breast cancer
Here we quantified tyrosine phosphorylation (pTyr) mediated signaling networks in chemotherapy sensitive (CS) and resistant (CR) TNBC patient derived xenografts (PDX) to gain novel therapeutic insights. We identified Src Family Kinases (SFKs) as potential therapeutic targets in CR TNBC PDXs. Additio...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD034154 | Pride
Phosphoproteomics Breast cancer Phosphotyrosine Chemotherapy resistance Tnbc 
ProteomicsDegron models: a toolbox for rapid in vivo depletion of essential proteins regulating mRNA metabolism
Due to their essentiality, studying proteins involved in fundamental processes in vivo is challenging. PROTAC-based systems offer time-controlled protein depletion, but their characterization in vivo remains limited. Here, with an efficient direct zygote editing protocol, we generated degron-tag mod...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-26 | PXD069282 | Pride
Tmt Degron-tag Liver Mouse 
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