Sort   by:  
 Page size 
ProteomicsA cis-regulatory element controls HDAC9 expression to fine-tune inflammasome-dependent chronic inflammation
To understand the underlying molecular mechanism of Hdac9-mediated inflammasome activation and motivated by the molecular scaffolding function of HDAC9, we pursued the hypothesis that HDAC9 may serve as a docking site for cytosolic inflammasome components thereby facilitating its rapid formation upo...
ORGANISM(S): Homo sapiens (Human) 
2025-07-10 | PXD042078 | Pride
Inflammation Inflammasome Atherosclerosis Hdac9 Nlrp3 
ProteomicsPeptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells
Inhibiting protein-protein interactions via designed peptides is a suitable strategy to block the function of important proteins in cells. The Elongin BC heterodimer (ELOB/C) is involved in transcription elongation and protein turnover. It interacts with target proteins via a so-called BC-box to mod...
ORGANISM(S): Homo sapiens (Human) 
2023-06-27 | PXD038414 | Pride
Peptide inhibition Elongin bc Cancer Prc2 Epop 
ProteomicsThe histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA-binding winged helix domainThe histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA-binding winged helix domain
The lysine acetyltransferase KAT6A (MOZ, MYST3) belongs to the MYST family of chromatin regulators, facilitating histone acetylation. Dysregulation of KAT6A has been implicated in developmental syndromes and the onset of acute myeloid leukemia (AML). Previous work suggests that KAT6A is recruited to...
ORGANISM(S): Homo sapiens (Human) 
2023-01-14 | PXD034833 | Pride
Winged helix Histone acetylation Cpg islands Kat6a Chromatin 
TranscriptomicsTranscription profiling of mouse dendritic cells treated with Lactobacillus acidophilus to investigate the induction of virus immune defense genes
Lactobacilli are probiotics that, among other health promoting effects, have been ascribed immunostimulating and virus preventive properties. Certain lactobacilli species have been shown to possess strong IL-12 inducing properties. As IL-12 production depends on the up-regulation of type I interfero...
ORGANISM(S): Mus musculus 
2009-10-20 | E-GEOD-18460 | biostudies-arrayexpress
UnknownTumour-reactive heterotypic CD8 T cell clusters from clinical samples.
Not available
S-EPMC12779571 | biostudies-literature
UnknownEconomic evaluation alongside the Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (E-PROSPECT): study protocol.
Not available
S-EPMC7322334 | biostudies-literature
UnknownEffects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study.
Not available
S-EPMC9210173 | biostudies-literature
UnknownGlobal variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries.
Not available
S-EPMC7846817 | biostudies-literature
Sort   by:  
 Page size