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ProteomicsSpatially-Resolved Top-Down Proteomics of Zebrafish Brain Using Capillary Zone Electrophoresis-Tandem Mass Spectrometry
Understanding region-specific proteoform profiles in the brain is crucial for deciphering neural function and identifying potential therapeutic targets. Here, we present a comprehensive label-free quantitative top-down proteomics (TDP) analysis of distinct zebrafish brain regions using capillary zon...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2026-06-08 | PXD070925 | Pride
Proteoform Top-down proteomics Zebrafish brainregions 
ProteomicsOn tissue Top down microproteomic bridged to MALDI MS Imaging reveal the molecular physiome of brain regions
Tissue Top-down microproteomic was performed on 3 brain regions. 156 references proteins from different cellular compartments were characterized. Moreover, 11 Alternative proteins issued from alternative open reading frames (AltORF) were identified and were relied to the brain regions and associated...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-11-14 | PXD005424 | Pride
Alternative proteins Top down micro-proteomics Maldi imaging 
ProteomicsOvarian serous cancer tumor microenvironment investigated by MALDI MSI associated to Top-down microproteomic: Evidence of a hidden proteome as novel potential target
Top-down tissue microproteomic was performed in order to investigate tumoral tissue microenvironment. 289 proteins with post-translational modifications have been isolated from biospies including Tumor, Borderline and healthy regions of serous ovarian cancers. Tumor tissue displays a majority of pro...
ORGANISM(S): Homo sapiens (Human) 
2017-06-23 | PXD005420 | Pride
Alternative proteins Top down micro-proteomics Maldi imaging 
Proteomicsmicro-proteomics experiment for single meiotic-phase barley anthers
We describe here a new micro-proteomics workflow for the analysis of individual barley anthers. The workflow detects more than 4000 proteins from small amounts of material representing single or paired anther samples, covering a dynamic range of protein expression levels across five orders of magnit...
ORGANISM(S): Hordeum vulgare (Barley) 
2019-05-04 | PXD010887 | Pride
Barley Micro-proteomics Anther 
TranscriptomicsTranscription profiling of wild type and ZakA and GskA knock-out Dictyostelium discoideum to investigate the Zak1-GSK-3 signalling pathway
GskA, the Dictyostelium GSK-3 orthologue, is modified and activated by the dual-specificity tyrosine kinase Zak1 and the two kinases form part of a signalling pathway that responds to extracellular cAMP. We identify potential cellular effectors for the two kinases by analysing their null mutants. Th...
ORGANISM(S): Dictyostelium discoideum 
2007-10-24 | E-SGRP-4 | biostudies-arrayexpress
UnknownProtein identification in imaging mass spectrometry through spatially targeted liquid micro-extractions.
Not available
S-EPMC5812809 | biostudies-literature
ProteomicsHeat-induced proteomes in tomato pollen mother cells
Tomato pollen production and viability is highly vulnerable to higher temperature. Hot summers with temperature reaching above 32°C can disrupt production of viable pollens and fruit set, resulting in yield loss. In recent years, temperature above 35-38oC has become a norm during mid-summer with po...
ORGANISM(S): Solanum lycopersicum 
2022-04-07 | PXD018915 | Pride
Tmt proteomics Pollen mother cells Laser capture microdissection Heat stress project description 
ProteomicsQuantification of proteins in the endothelial cell-pericyte interface with and without treatment with 19,20-dihydroxydocosapentaenoic acid (19,20-DHDP)
Goal of the study was to identify (using proteomics) the consequences of the lipocine 19,20-DHDP on the proteins enriched in the junctions between endothelial cells and pericytes.
ORGANISM(S): Homo sapiens (Human) 
2025-01-07 | PXD049131 | Pride
Lc-ms/ms Cell-cell junctions Endothelial cells 20-dhdp Pericytes 19 
ProteomicsAn Abundance of Free Proteasomal Regulatory (19S) Particles Regulate Neuronal Synapses Independent of the Proteasome
The major protein-degradation machine, the proteasome, functions at brain synapses and regulates long-term information storage. Here we found that the two essential subcomplexes of the proteasome, the regulatory (19S) and catalytic (20S) particles that assemble to recognize and degrade substrates, w...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-11-26 | PXD037893 | Pride
K48 Synapse Neurons Neuronal proteasome 19s K63 Pull-down Immunoprecipitation Proteasome Ubiquitin 
ProteomicsInteracting proteins on lncRNA SMANTIS in THP-1 cells
The lncRNA SMANTIS (formerly known as MANTIS, AK125871, n342419) functions as a regulator of cell function in endothelial cells and for adhesion to monocytes. Here, we investigated the function of SMANTIS in THP-1 monocytes. By using an antisense oligonucleotide pulldown approach followed by LC/MS, ...
ORGANISM(S): Homo sapiens (Human) 
2025-01-07 | PXD048847 | Pride
Monocytes Complex remodeling Lncrna Protein-rna complexes 
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