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ProteomicsMass spectrometry of immunoprecipitations from control and Er blood group
Immunoprecipitates were prepared from test Er(a+b-) donor RBCs and negative control Er(a-b+) (P1) RBCs using anti-Era plasma from P3 (5:1 ratio of plasma to cells) and proteomic analysis was performed.
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD035013 | Pride
Human Red blood cells Lcms 
ProteomicsNanoLC-MSMS Phosphoproteomics comparison of in vitro cultured/native reticulocytes and erythrocytes
Triplicate samples of donor-matched native reticulocytes (CD71+ cells), erythrocytes (CD71- cells) and in vitro culture-derived reticulocytes (derived from CD34+ cells) were analysed through qualitative phosphoproteomics to examine possible novel mechanisms underlying reticulocyte maturation.
ORGANISM(S): Homo sapiens (Human) 
2018-08-03 | PXD009015 | Pride
Human Phospho Reticulocyte Nanolc-msms Erythrocyte Erythropoiesis 
ProteomicsNanoLC-MSMS Phosphoproteomics comparison of in vitro cultured reticulocytes and red blood cells before, during and after microsphiltration
Four samples of in vitro culture-derived reticulocytes (biological replicates, derived from CD34+ cells) and three samples of red blood cells (biological replicates) were analysed through qualitative phosphoproteomics before, during and after passage through a spleen-mimicking microsphiltration devi...
ORGANISM(S): Homo sapiens (Human) 
2019-09-12 | PXD013960 | Pride
Red blood cell Blood Reticulocyte Erythrocyte Deformation 
ProteomicsNanoLC-MSMS Phosphoproteomics comparison of in vitro cultured reticulocytes before and after passage through microfluidic capillaries
Triplicate samples (biological replicates) of in vitro culture-derived reticulocytes (derived from CD34+ cells) were analysed through qualitative phosphoproteomics before and after passage through a microfluidics capillary chip to investigate the mechanisms underlying shear stress recognition.
ORGANISM(S): Homo sapiens (Human) 
2019-09-12 | PXD013652 | Pride
Human Red blood cell Phospho Reticulocyte Nanolc-msms Erythrocyte Erythropoiesis 
ProteomicsEnhancement of red blood cell transfusion compatibility using CRISPR-mediated erythroblast gene editing
Regular blood transfusion is the cornerstone of care for patients with red blood cell (RBC) disorders such as thalassemia or sickle cell disease. With repeated transfusion, alloimmunisation often occurs due to incompatibility at the level of minor blood group antigens. We use CRISPR-mediated genome ...
ORGANISM(S): Homo sapiens (Human) 
2018-04-26 | PXD009291 | Pride
Erythroid Blood Crispr Bel-a. transfusion Universal donor 
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