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TranscriptomicsTP53 sequence of human glioblastoma stem cells sorted for p53-Ser15 induction and NS1 virus protein expression upon parvovirus MVMp infection
We have analyzed whether mutations in the TP53 gene and post-translational phosphorylation in the Ser-15 residue of the p53 protein (Pp53) may confer permissiveness to the prototype strain of the parvovirus Minute Virus of MIce ( MVMp) infection in human glioblastoma stem cells (GSCs) isolated from ...
ORGANISM(S): Homo sapiens 
2021-07-13 | E-MTAB-9359 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of nasopharyngeal carcinoma cell line HNE2 following TP53 overexpression
Recent studies have revealed that long non-coding RNAs (lncRNAs) participate in all steps of cancer initiation and progression by regulating protein coding genes at the epigenetic, transcriptional and post-transcriptional levels. LncRNAs are in turn regulated by other genes, forming a complex regula...
ORGANISM(S): Homo sapiens 
2015-05-14 | E-GEOD-60379 | biostudies-arrayexpress
TranscriptomicsTP53 mutation status and gene expression profiles are powerful prognostic markers of breast cancer
Background: Gene expression profiling of breast carcinomas has increased our understanding of the heterogeneous biology of this disease and promises to impact clinical care. The aim of this study was to evaluate the prognostic value of gene expression-based classification along with established prog...
ORGANISM(S): Homo sapiens 
2012-09-18 | E-GEOD-40954 | biostudies-arrayexpress
ProteomicsSARS-CoV-2 spike sequence dictates host TP53 activity and COVID-19 pathogenicity
SARS-CoV-2 induces widespread transcriptomic changes in host cells upon infection, in part through activation and modulation of innate immunity pathways and downstream gene regulation. However, the mechanisms by which SARS-CoV-2 and its evolutionary variants differentially affect host cell transcrip...
ORGANISM(S): Chlorocebus sabaeus 
2023-09-09 | PXD034648 | Pride
Idapt-ms Sars-cov-2 Covid-19 Tp53 Spike 
ProteomicsReduced structural rigidity of MDMX protein enhances binding to TP53 mRNA
The two murine double minute (MDM) family members, MDM2 and MDMX are a well-established negative regulator of p53 activity. Under DNA damage conditions, MDM2 and MDMX are phosphorylated near their RING domains (serine 395 at MDM2 and serine 403 at MDMX) and switch to act as p53 positive regulators. ...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD060074 | Pride
Human Mdmx-mdm2 interaction P53 mrna stabilization Ring domain Hdx-ms mapping Lc-ms/ms 
ProteomicsRNA and phosphoprotein profiles of TP53- and PTEN-knockouts in MCF10A at baseline and responding to DNA damage
A wealth of proteogenomic data has been generated using cancer samples to deepen our understanding of the mechanisms of cancer and how biological networks are altered in association with somatic mutation of tumor suppressor genes, such as TP53 and PTEN. To generate functional signatures of TP53 or P...
ORGANISM(S): Homo sapiens (Human) 
2023-11-20 | PXD028494 | Pride
Knockout Imac Phosphoproteomics Silac Mms Mcf10a Lc-ms/ms 
TranscriptomicsWild Type Tumor Repressor Protein 53 (TRP53) Promotes Ovarian Cancer Cell survival
Loss of Pten in the KrasG12D;Amhr2-Cre mutant mice leads to the transformation of ovarian surface epithelial (OSE) cells and rapid development of low-grade, invasive serous adenocarcinomas. Tumors occur with 100% penetrance and express elevated expression of wild type tumor repressor protein 53 (TRP...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-34882 | biostudies-arrayexpress
ProteomicsThe HLA peptide repertoire of SaOS-2 cell line transfected with TP53 protein
Analysis of the immunopeptidome of Human Leukocyte Antigen(HLA)class I of SaOS-2 osteosarcoma cells transfected with pBR322 vector only, and 2 mutants of TP53 protein namely R175H and R273H.
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD034044 | Pride
Hla Saos-2 Immunopeptidomics Tp53 protein Lc-ms/ms 
Proteomicsnascent proteome analysis of HCT116 TP53 wild type and TP53 knockout cells treated with Neocarcinostatin (NCS) for 6h
In order to investigate the potential role of TP53 in regulating translation, HCT116 wild type and TP53 knockout cells were analyzed using both RNA sequencing, Ribosome sequencing and nascent proteome analysis. The cells were treated with 0.2 µg/ml Neocarcinostatin (NCS) to induce DNA damage and act...
ORGANISM(S): Homo sapiens (Human) 
2022-04-27 | PXD029512 | Pride
Tp53 Ncs Nascent proteome Metabolic labeling Dna damage 
TranscriptomicsGene expression profiles of DFCs and SHED 48 hours after in vitro transfection with a TP53 plasmid, a SP1 plasmid, or an empty vector.
Dental follicle is a loose connective tissue that surrounds the developing tooth. Dental follicle cells (DFCs) have a promising potential for tissue engineering applications including periodontal and bone regeneration. However, little is known about the molecular mechanisms underlying osteogenic dif...
ORGANISM(S): Homo sapiens 
2011-08-24 | E-GEOD-31628 | biostudies-arrayexpress
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