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ProteomicsProteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links part 2 of 2: AP-MS DATA (QUBIC)
DNA interstrand crosslinks (ICLs) block replication fork progression by inhibiting DNA strand separation. Repair of ICLs requires sequential incisions, translesion DNA synthesis, and homologous recombination, but the full set of factors involved in these transactions remains unknown. Here we establi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-13 | MSV000079577 | MassIVE
ProteomicsDNA polymerase kappa is the primary translesion synthesis polymerase for aldehyde ICLs
DNA interstrand crosslinks (ICLs) are highly cytotoxic lesions that block essential cellular processes like replication and transcription. Endogenous ICLs can be induced by reactive aldehydes produced during normal cellular metabolism. Defective repair of these aldehyde-induced ICLs is associated wi...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2025-09-29 | PXD062134 | Pride
Acrolein-icl Fa pathway Acetaldehyde-icl Polymerase kappa Translesion synthesis 
GenomicsPrimordial germ cell DNA demethylation and development require DNA translesion synthesis
Primordial germ cell DNA demethylation and development require DNA translesion synthesis
PRJNA1068075 | ENA
ProteomicsDNA polymerase kappa is the primary translesion synthesis polymerase for aldehyde ICLs
DNA interstrand crosslinks (ICLs) are highly cytotoxic lesions that block essential cellular processes like replication and transcription. Endogenous ICLs can be induced by reactive aldehydes produced during normal cellular metabolism. Defective repair of these aldehyde-induced ICLs is associated wi...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2025-09-29 | PXD066315 | Pride
Dna polymerase kappa Acrolein-icl Translesion synthesis Fanconi anemia pathway Acetaldehyde-icl 
ProteomicsThe E3 ubiquitin ligase RFWD3 is required for translesion DNA synthesis
Lesions on DNA can uncouple DNA synthesis from helicase unwinding, generating stretches of unreplicated single stranded DNA (ssDNA) behind the replication fork. These ssDNA gaps need to be filled in to complete DNA duplication and thereby avoid the generation of DNA double-stranded breaks (DSBs), a ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2020-12-15 | PXD018217 | Pride
Chromass Tls Xenopus Rfwd3 Dna Damage Ubiquitin Pcna Ts 
ProteomicsThe E3 ubiquitin ligase RFWD3 is required for translesion DNA synthesis (total proteome)
Lesions on DNA can uncouple DNA synthesis from helicase unwinding, generating stretches of unreplicated single stranded DNA (ssDNA) behind the replication fork. These ssDNA gaps need to be filled in to complete DNA duplication and thereby avoid the generation of DNA double-stranded breaks (DSBs), a ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2020-12-15 | PXD021445 | Pride
Chromass Tls Xenopus Rfwd3 Total proteome Dna Damage Ubiquitin Pcna Ts 
GenomicsTranslesion DNA synthesis-driven mutagenesis in very early embryogenesis of fast cleaving embryos
Translesion DNA synthesis-driven mutagenesis in very early embryogenesis of fast cleaving embryos
PRJNA677917 | ENA
ProteomicsCatalytic and non-catalytic functions of DNA polymerase kappa in translesion DNA synthesis
Translesion DNA synthesis (TLS) is a cellular process that enables the bypass of DNA lesions encountered during DNA replication and is emerging as a primary target of chemotherapy. Among vertebrate DNA polymerases, polymerase kappa (PolK) has the distinctive ability to bypass minor groove DNA adduct...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2024-08-27 | PXD044258 | Pride
Xenopus Tls Polz Polk Rev1 Polymerase kappa Ubiquitin Translesion dna synthesis Pcna Dna replication 
TranscriptomicsThe NuA4 complex promotes Translesion Synthesis (TLS) - mediated DNA damage tolerance
DNA lesions can block a replication fork, leading to its collapse and gross chromosomal rearrangements. To circumvent such outcomes, DNA damage tolerance (DDT) pathways become engaged, allowing the replisome to bypass the lesion and complete S phase in the presence of unrepaired damage. Here we demo...
ORGANISM(S): Saccharomyces cerevisiae 
2015-02-21 | E-GEOD-66176 | biostudies-arrayexpress
UnknownPCNA trimer instability inhibits translesion synthesis by DNA polymerase η and by DNA polymerase δ.
Not available
S-EPMC3636165 | biostudies-literature
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