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UnknownA versatile strategy for rapid conditional genome engineering using loxP sites in a small synthetic intron in Plasmodium falciparum.
Not available
S-EPMC4759600 | biostudies-literature
ProteomicsPerTurboID of Plasmofium falciparum cytoadhesion complex
In this project proximity labeling was used to first identify proteins in the close vicinity of the P. falciparum exported kinase FIKK4.1 by fusing it to a biotin ligase. A conditional KO of the exported kinase FIKK4.1 was then generated for two identified targets, PTP4 and Kahrp in a FIKK4.1 condit...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum NF54 
2023-09-21 | PXD039125 | Pride
Malaria plasmodium falciparum red blood cells lc-ms/ms 
ProteomicsTurboID Proximity Profiling of FIKK10.2 (PF3D7_1039000) in Plasmodium falciparum–Infected Red Blood Cells During Febrile Heat Stress
This project investigates how febrile heat stress alters the local protein environment of the Maurer’s cleft resident kinase FIKK10.2 in the malaria parasite Plasmodium falciparum. During human infection, parasites are routinely exposed to elevated temperatures associated with fever, yet how this ph...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) 
2026-05-14 | PXD073890 | Pride
Proximity labelling Heat stress Turboid Plasmodium falciparum 
ProteomicsGlobal profiling of myristoylation in Toxoplasma gondii
N-myristoylation is a ubiquitous class of protein lipidation across eukaryotes and N-myristoyl transferase (NMT) has been proposed as an attractive drug target in several pathogens. Here we describe the first global chemoproteomic analysis of protein myristoylation in Toxoplasma gondii. Through quan...
ORGANISM(S): Homo sapiens (Human) Toxoplasma gondii RH 
2020-07-06 | PXD019677 | Pride
N-myristoylation Chemical proteomics Toxoplasma Nmt inhibition 
ProteomicsPhosphoproteomics of Plasmodium falciparum infected red blood cells under Heat Stress
This project investigates changes in protein phosphorylation in the malaria parasite Plasmodium falciparum in response to heat stress. During infection parasites are exposed to febrile temperatures in the human host. Heat stress is known to trigger adaptive responses but the role of protein phosphor...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) 
2026-05-14 | PXD073843 | Pride
Phosphoproteomics Heat stress Plasmodium falciparum 
ProteomicsA positive feedback loop mediates crosstalk between calcium, cyclic nucleotide and lipid signaling in Toxoplasma gondii.
Fundamental processes of obligate intracellular parasites, such as Plasmodium falciparum and Toxoplasma gondii are controlled by a set of plant-like calcium dependent kinases (CDPKs), the conserved cAMP- and cGMP-dependent protein kinases (PKA and PKG), second messengers and lipid signalling. While ...
ORGANISM(S): Homo sapiens (Human) Toxoplasma gondii RH 
2022-10-17 | PXD030057 | Pride
Toxoplasma gondii Calcium-signalling Egress Cdpk3 
ProteomicsAn Exported Kinase Family Mediates Species-Specific Erythrocyte Remodelling and Virulence in Human Malaria
The most severe form of human malaria is caused by Plasmodium falciparum. Its virulence is closely linked to the increase in rigidity and cytoadhesion of infected erythrocytes, which obstruct blood flow to vital organs. Unlike other human-infecting Plasmodium species, P. falciparum exports a family ...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) Plasmodium knowlesi strain H 
2020-04-17 | PXD015833 | Pride
Plasmodium Fikk kinases Malaria Red blood cell Phosphorylation 
ProteomicsDifferential protein phosphorylation during stage conversion in Toxoplasma gondii
The intracellular parasite Toxoplasma gondii resides within a membrane bound parasitophorous vacuole and secretes an array of proteins to establish this replicative niche during acute stage of infection. When rapidly dividing tachyzoites convert to chronic stage bradyzoites, many secreted proteins a...
ORGANISM(S): Homo sapiens (Human) Toxoplasma gondii ME49 
2020-06-12 | PXD019729 | Pride
Stage conversion Bradyzoites Phosphorylation Tachyzoites Toxoplasma 
ProteomicsToxoplasma gondii PRU ROP1-HA Co-Immunoprecipitation
Toxoplasma gondii is an intracellular parasite that can infect many different host species and is a cause of significant human morbidity worldwide. T. gondii secretes a diverse array of effector proteins into the host cell which are critical for infection; however, the vast majority of these secrete...
ORGANISM(S): Toxoplasma gondii PRU Mus musculus (Mouse) 
2022-10-20 | PXD032319 | Pride
Toxoplasma gondii 
GenomicsHistone variant, H2B.Z demarcates the AT-rich promoter regions of the Plasmodium falciparum genome
Histone variants are key components of the epigenetic code and evolved to perform specific functions in transcriptional regulation, DNA repair, chromosome segregation and other fundamental processes. H2B.Z is a rare, apicomplexan-specific variant of histone H2B. Here we show that in Plasmodium falci...
ORGANISM(S): Plasmodium falciparum 3D7 
2013-03-05 | E-GEOD-39702 | biostudies-arrayexpress
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