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UnknownAnalysis of the effect of the mitochondrial prohibitin complex, a context-dependent modulator of longevity, on the C. elegans metabolome.
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S-EPMC4580209 | biostudies-literature
ProteomicsFGF21 modulates mitochondrial stress response in cardiomyocytes only under mild mitochondrial dysfunction
Mitochondrial integrated stress response emerged as a major adaptive pathway to respiratory chain deficiency, but tissue-specifics of its regulation or how it adapts to different levels of mitochondrial dysfunction are largely unknown. Here we report that diverse levels of mitochondrial cardiomyopat...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-27 | PXD031324 | Pride
Mitochondria Fgf21 Oxphos Cardiomyopathy Clpp 
ProteomicsSalvage pathway maintains functional respiratory complex I
Regulation of the turnover of complex I (CI), the largest mitochondrial respiratory chain complex remains enigmatic, despite huge advancement in understanding its structure and the assembly steps in recent years. Although some studies indicated that CI might be remodelled in response to various stim...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-05 | PXD014897 | Pride
Mitochondrial respiratory complex i  proteolytic control  salvage pathway  respiratory deficiency  clpxp protease 
ProteomicsDynamic complexome profiling identifies impaired protein turnover in mouse CLPP-/-embryonic fibroblasts
We studied dynamics within mitochondrial complexes in MEFs from CLPP-/- and wildtype mice.
ORGANISM(S): Mus musculus (Mouse) 
2020-03-05 | PXD017463 | Pride
Psilac Complex i Mitochondria Lc-msms Complexome profiling 
ProteomicsProtein exchange rates within mitochondrial protein complexes of differentiated myotubes using pulsed SILAC complexome profiling
We studied dynamics within stable mitochondrial complexes in differentiated mouse myotubes by pulsed SILAC complexome profiling.
ORGANISM(S): Mus musculus (Mouse) 
2020-03-05 | PXD017465 | Pride
Complex i Mitochondria Lc-msms Complexome profiling 
ProteomicsQuantification of proteins and oxidized proteins in wild type and CLPP deficient mouse heart mitochondria.
We studied consequences of CLPP deletion to mitochondrial proteome and redox-proteome.
ORGANISM(S): Mus musculus (Mouse) 
2020-03-05 | PXD017464 | Pride
Complex i Mitochondria Redox proteomics Lc-msms 
Proteomics2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction
Mitochondria play a crucial role in regulating cellular homeostasis in response to intrinsic and extrinsic cues by changing cellular metabolism to meet these challenges. However, the molecular underpinnings of this regulation and the complete spectrum of these physiological outcomes remain largely u...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-26 | PXD064288 | Pride
Nuclear softening Brown adipose tissue Mitochondria 2-hydroxyglutarate 
ProteomicsObesity causes irreversible mitochondria failure in visceral adipose tissue despite successful anti-obesogenic lifestyle-based interventions
Metabolic plasticity is the ability of a biological system to adapt its metabolic phenotype to different environmental stressors. We used a whole-body and tissue- specific phenotypic, functional, metabolomic and transcriptomic approach to systematically assess metabolic plasticity in diet-induced ob...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-04 | PXD025503 | Pride
Obesity Ewat Mouse High-fat diet Visceral adipose tissue 
ProteomicsThe let-7 family of miRNA mediates paternal intergenerational inheritance of metabolic disorders via post-transcriptional regulation of mitochondrial dynamics.
This study aims to investigate the molecular mechanisms and nature of impaired soma-germline crosstalk in IEI by focusing on the miRNA regulations in soma and sperm of obese male mice. We found that F0 HFD deteriorated glucose metabolism in F0 and F1, whereas F0 weight loss largely corrected glucose...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-06 | PXD042800 | Pride
Metabolic diseases Mitochondrial dysfunction Microrna Intergenerational epigenetic inheritance Let-7 
ProteomicsPhosphoproteomics of the developing heart identifies PERM1 - an outer mitochondrial membrane protein
Heart development relies on PTMs that control cardiomyocyte proliferation, differentiation and cardiac morphogenesis. We generated a map of phosphorylation sites during the early stages of cardiac postnatal development in mice; we quantified over 10,000 phosphorylation sites and 5000 proteins that w...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-07-21 | MSV000085796 | MassIVE
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