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ProteomicsIdentification of sites of ubiquitination in human UBQLN2
Using immunoprecipitations from HEK293T cells of UBQLN2-HA constructs, sites of ubiquitination were identified. A variety of UBQLN2 variants were studied including lysineless proteins, deletions of the UBL domain and N-terminal fusions to ubiquitin.
ORGANISM(S): Homo sapiens (Human) 
2025-12-17 | PXD059465 | Pride
Ubiquilin ubiquitin ubqln2 ubl 
ProteomicsGlobal proteomics of Ubqln2-based murine models of ALS
Familial neurodegenerative diseases commonly involve mutations that result in either aberrant proteins or dysfunctional components of the proteolytic machinery that acts on aberrant proteins. UBQLN2 is a ubiquitin receptor of the UBL/UBA family that binds the proteasome through its ubiquitin-like (...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-01-20 | PXD021991 | Pride
Proteomics Als Ubqln2 Proteasome Ubiquitin ligase Neurodegeneration Ubiquitin 
ProteomicsWhole-cell abundance profiling and interaction analysis of UBQLN2
To address whether expression of ALS/FTD-associated UBQLN2 mutant variants changes the cellular proteome, we performed label-free quantification-based global protein abundance profiling of patient-derived LCLs and CRISPR engineered HeLa cells. UBQLN2 mutant in both cell lines carried the mutation T4...
ORGANISM(S): Homo sapiens (Human) 
2022-06-24 | PXD029747 | Pride
Whole proteome Ha-ip Hela Lcl Als/ftd Ubqln2 
GenomicsUBQLN2 Links Proteotoxicity with Lipid Metabolism in Neurodegeneration
UBQLN2 Links Proteotoxicity with Lipid Metabolism in Neurodegeneration
PRJNA1139765 | ENA
TranscriptomicsUBQLN2 Links Proteotoxicity with Lipid Metabolism in Neurodegeneration
Protein homeostasis and lipid metabolism are crucial cellular processes that are dysregulated in neurodegeneration. However, their connection in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) remains unexplored. Ubiquilin 2 (UBQLN2) is a prot...
ORGANISM(S): Homo sapiens 
2025-07-01 | GSE272994 | GEO
ProteomicsUBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS
Amyotrophic Lateral Sclerosis (ALS) is a rare neurodegenerative disease characterized by motor neuron dysfunction and loss, leading to progressive paralysis and death. A portion of ALS cases is caused by mutation of the proteasome shuttle factor Ubiquilin 2 (UBQLN2), but the molecular pathway leadin...
ORGANISM(S): Homo sapiens (Human) 
2023-03-24 | PXD031964 | Pride
Q-exactive hf-x Tmt Als Human spinal cord 
ProteomicsPhosphoproteomic analysis of UBQLN2 mutant cells
In the project “Phosphoproteomic analysis of UBQLN2 mutant cells” by Laura Strohm, Zehan Hu, Jörn Dengjel, and Christian Behrends eight sets of SILAC experiments were performed, two times four biological replicates, comparing proteome and phosphoproteome of control and UBQLN2 mutant, patient-derived...
ORGANISM(S): Homo sapiens (Human) 
2022-06-28 | PXD029730 | Pride
Human Lc-msms Lcl Phosphoproteomics 
ProteomicsEndogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology
The human genome is replete with sequences derived from foreign elements including endogenous retrovirus-like proteins of unknown function. The human genome is replete with sequences derived from foreign elements including endogenous retrovirus-like proteins of unknown function. Here we show that UB...
ORGANISM(S): Homo sapiens (Human) 
2025-06-04 | PXD061852 | Pride
Stress granules Retrotransposon-derived proteins Ubiquilins 
UnknownPathogenic Ubqln2 gains toxic properties to induce neuron death.
Not available
S-EPMC4777328 | biostudies-literature
UnknownGlobal proteomics of Ubqln2-based murine models of ALS.
Not available
S-EPMC7873701 | biostudies-literature
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