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ProteomicsProfiling CTBP2’s genome-wide interactome in murine macrophages during LPS-induced inflammation – oligomerization-dependent interactions
To identify oligomerization dependent interactors of C-terminal binding protein 2 (CTBP2), we stably expressed CTBP2 wild type or a monomeric mutant (CTBP2 mono: CTBP2 C140Y, N144R, R147E, L156W) in Ctbp1-/-, Ctbp2-/- J774.1 cells and profiled their genome-wide interactome in LPS conditions after 3 ...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-08 | PXD063883 | Pride
Lps Macrophage J774.1 Ctbp2 Inflammation Oligomerization Mouse Chip-ms 
ProteomicsProfiling CTBP2’s genome-wide interactome in murine macrophages in resting state and during LPS-induced inflammation
We profiled the genome-wide interactome of the co-repressor C-terminal binding protein 2 (CTBP2) in primary murine macrophages (BMDM) in vehicle and LPS conditions after 3 h of stimulation. We find that CTBP2 interacts with the transcription factors NF-κB and AP-1 and forms a corepressor complex tha...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-08 | PXD063850 | Pride
Lps Macrophage Ctbp2 Inflammation Bmdm Mouse Chip-ms 
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