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Transcriptomics3' mRNA-seq of human Ma-Mel-47 (melanoma) and Panc89 (PDAC) cells treated with the USP7 degraders NK266 and NK250, respectively, for 72 h.
3' mRNA-seq was used to study the effects of USP7 degradation by the degraders NK266 and NK250 on gene expression in a human melanoma and PDAC cell line, respectively.
ORGANISM(S): Homo sapiens 
2026-03-27 | E-MTAB-16302 | biostudies-arrayexpress
GenomicsTranscriptome profiling in USP7 inhibitor (P22077)-treated H1299 and HeLa cells
Transcriptome profiling in USP7 inhibitor (P22077)-treated H1299 and HeLa cells
PRJNA883214 | ENA
TranscriptomicsYG001: A Usp7-Tip60 pathway regulates early adipogenesis
USP7, a dominant DUB activity in 3T3-L1 adipocytes and in mouse adipose tissue, increases Tip60 protein levels, and deubiquitinates Tip60 both in intact cells and in vitro. Treatment with a pan deubiquitinase (DUB) inhibitor, or knockdown of USP7, decreases adipogenesis. Transcriptome analysis revea...
ORGANISM(S): Mus musculus 
2013-08-28 | E-GEOD-28587 | biostudies-arrayexpress
GenomicsChromatin organization in T-ALL cells upon USP7 inhibitor with or without dexamethasone (Hi-C)
Chromatin organization in T-ALL cells upon USP7 inhibitor with or without dexamethasone (Hi-C)
PRJNA757417 | ENA
GenomicsChromatin accessibility in T-ALL cells upon USP7 inhibitor with or without dexamethasone (RNA-Seq)
Chromatin accessibility in T-ALL cells upon USP7 inhibitor with or without dexamethasone (RNA-Seq)
PRJNA757415 | ENA
GenomicsChromatin accessibility in T-ALL cells upon USP7 inhibitor with or without dexamethasone (ATAC-Seq)
Chromatin accessibility in T-ALL cells upon USP7 inhibitor with or without dexamethasone (ATAC-Seq)
PRJNA757416 | ENA
ProteomicsUSP7, a protein involved in Hao-Fountain syndrome, controls neuronal differentiation via BCOR-ncPRC1.1
Pathogenic variants in the ubiquitin-specific protease 7 (USP7) gene cause a neurodevelopmental disorder called Hao-Fountain syndrome. However, which of its pleiotropic substrates are relevant for neurodevelopment is undetermined. Here, we present a combination of quantitative proteomics, transcript...
ORGANISM(S): Homo sapiens (Human) 
2025-09-08 | PXD051616 | Pride
Usp7 Prm Dia-ms Label free quantitative proteomics Neuronal differentiation Bcor Hao-fountain syndrome 
TranscriptomicsTranscriptome profiling in USP7 inhibitor (P22077)-treated H1299 and HeLa cells
To investigate the molecular pathway signature responsive to pharmacological inhibition of USP7, we analyzed transcriptome in P22077 (a USP7 selective inhibitor)-treated H1299 and HeLa cells.
ORGANISM(S): Homo sapiens 
2023-09-30 | GSE213931 | GEO
ProteomicsThe USP7-TRIM27 axis as part of non-canonical PRC1.1 is a druggable target in leukemia
In an attempt to unravel the functionality and targettability of the non-canonical PRC1.1 Polycomb complex in human leukemogenesis, we dissected the subunit composition of the PRC1.1 complex and show that USP7 and TRIM27 are integral components. USP7 interactome analyses show that PRC1.1 is the pred...
ORGANISM(S): Homo sapiens (Human) 
2021-06-14 | PXD018365 | Pride
Trim27 Leukemia Prc1.1 Polycomb Usp7 
UnknownUSP7 V517F mutation as a mechanism of inhibitor resistance.
Not available
S-EPMC11909274 | biostudies-literature
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