Whole Proteome measurement of pancreatic cancer cells (Panc89) or melanoma cells (MaMel47) treated with USP7 inhibitors and degrader to compare phenotypes induced by inhibition compared to degradation. We synthesized and characterized potent USP7-targeting degrader molecules (PROTACs) and compared U...
3' mRNA-seq was used to study the effects of USP7 degradation by the degraders NK266 and NK250 on gene expression in a human melanoma and PDAC cell line, respectively.
Whole proteome measurement to determine selectivity profile for compound NK266 in melanoma as well as determining downstream signalling effects of DUB inhibition and degradation.
Whole proteome measurement to determine selectivitiy profile for compound NK250 in pancreatic cancer as well as determining downstream signaling effects of DUB inhibition and degradation.
Whole proteome measurement to determine selectivitiy profile for compound NK250 in pancreatic cancer as well as determining downstream signaling effects of DUB inhibition and degradation
