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ProteomicsA proteomic approach to identify vaccine candidates based on host cell attachment provides a novel protective Pseudomonas aeruginosa vaccine antigen: cell division protein, FtsZ
Pseudomonas aeruginosa is an opportunistic Gram negative pathogen that causes severe nosocomial infections in susceptible individuals due to the emergence of multi-drug resistant strains. There are no approved vaccines against P. aeruginosa infections nor candidates in active clinical development, h...
ORGANISM(S): Pseudomonas aeruginosa PA14 Bacteria 
2025-05-07 | PXD055823 | Pride
Antigens Pseudomonas aeruginosa Vaccine 
GenomicsPrototype LNP-mRNA vaccine candidates [SC_RNAseq]
Prototype LNP-mRNA vaccine candidates [SC_RNAseq]
PRJNA853803 | ENA
ProteomicsA mass spectrometry guided pre-clinical funnel for the identification of novel vaccine candidates against Helicobacter pylori
We established a generic pipeline for the identification of surface-exposed vaccine candidates in gram-negative bacteria. Using Helicobacter pylori as a model organism, our approach combines design of experiment driven surface shaving with quantitative mass spectrometry to identify 22 highly conserv...
ORGANISM(S): Helicobacter pylori J99 (Campylobacter pylori J99) 
2019-11-11 | PXD012566 | Pride
Proteomics Vaccine Surfome Helicobacter pylori 
ProteomicsPost-translational modifications of vaccine candidates of Cryptosporidium parvum
Here we describe the post translational modifications on vaccine candidate proteins from Cryptosporidium parvum. We have identified O-glycosylated peptides from GP15, GP40, GP900, and a novel mucin-like protein referred to as GP20. In addition, we have discovered that the immune dominant antigen, C...
ORGANISM(S): Cryptosporidium parvum 
2017-08-14 | PXD005989 | Pride
Cryptosporidium parvum Lipopeptides Vaccine candidates Glycopeptides Lc-ms/ms 
TranscriptomicsSystems analysis of the Merck Ad5/HIV vaccine reveals robust induction of a core innate immune gene network: in vivo analysis
Here we applied a systems approach to define human innate immune signatures following MRKAd5/HIV immunization and to analyze the effects of pre-existing Ad5 immunity. We defined the global early immune response to MRKAd5/HIV by profiling the PBMC transcriptomes from seven Ad5Neg individuals pre- and...
ORGANISM(S): Homo sapiens 
2012-11-20 | E-GEOD-22768 | biostudies-arrayexpress
ProteomicsQuantitative proteomics of the 2016 WHO Neisseria gonorrhoeae reference strains identifies vaccine candidates and antimicrobial resistance signatures.
Neisseria gonorrhoeae is the causative agent of gonorrhea, a leading sexually transmitted disease with severe complications on reproductive health. The U.S. Centers for Disease Control and Prevention has categorized the public health threat induced by N. gonorrhoeae as “urgent”, due to the ease of t...
ORGANISM(S): Neisseria gonorrhoeae FA6140 Neisseria gonorrhoeae 
2018-12-19 | PXD008412 | Pride
Who Proteomics Vaccine Neisseria gonorrhoeae Antimicrobial resistance 
ProteomicsComprehensive proteomics for Discovery vaccine candidates against Streptococcus equi Infections
Streptococcus equi subspecies equi (S. equi) is a major pathogen which cause strangles, a highly contagious respiratory infection, in horses and other equines. In this study, we purified the extracellular vesicles (EVs) of S. equi ATCC 39506 and evaluated them as vaccine candidates against S. equi i...
ORGANISM(S): Mus musculus (Mouse) Streptococcus equi subsp. equi 
2021-08-06 | PXD025527 | Pride
Label-free Lc-ms Streptococcus equi Extracellular vesicle Immunoprecipitation-ms 
ProteomicsComprehensive proteomics for Discovery vaccine candidates against Streptococcus equi Infections
Streptococcus equi subspecies equi (S. equi) is a major pathogen which cause strangles, a highly contagious respiratory infection, in horses and other equines.In this study, we discovered potential vaccine candidates using comprehensive proteomics and reverse vaccinology. As the initial step, we div...
ORGANISM(S): Streptococcus equi subsp. equi 4047 
2021-08-06 | PXD025152 | Pride
Secretory proteome Label-free Membrane proteome Streptococcus equi Extracellular vesicle Whole cell lysate Lc-ms Comprehensive proteome 
TranscriptomicsMerck Ad5/HIV induces broad innate immune activation that predicts CD8+ T-cell responses but is attenuated by preexisting Ad5 immunity.
This SuperSeries is composed of the following subset Series: GSE22768: Systems analysis of the Merck Ad5/HIV vaccine reveals robust induction of a core innate immune gene network: in vivo analysis GSE22769: Systems analysis of the Merck Ad5/HIV vaccine reveals robust induction of a core innate immun...
ORGANISM(S): Homo sapiens 
2012-11-20 | E-GEOD-22822 | biostudies-arrayexpress
UnknownPreviously unrecognized vaccine candidates control Trypanosoma cruzi infection and immunopathology in mice.
Not available
S-EPMC2519298 | biostudies-literature
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