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ProteomicsNative State Stabilization is an Effective Strategy to Inhibit TDP-43 Oligomerization and Fibrillogenesis
Transactive response DNA-binding protein 43 kDa (TDP-43) is a partially disordered nuclear protein that plays essential roles in RNA metabolism to maintain cellular homeostasis. In individuals with neurodegenerative diseases (NDDs), including Amyotrophic lateral Sclerosis (ALS), Alzheimer’s disease,...
ORGANISM(S): Homo sapiens (Human) Bacteria 
2026-06-24 | PXD041160 | Pride
Hdx-ms Aggregation Neuronal toxicity Oligonucleotides Tar dna binding protein (tdp-43) 
ProteomicsConoid extrusion serves as gatekeeper for entry of glideosome components into the pellicular space to control motility and invasion in Apicomplexa
Members of the apicomplexans are defined by apical cytoskeletal structures and secretory or-ganelles, tailored for motility and invasion. Gliding is powered by the actomyosin-dependent rearward translocation of apically secreted transmembrane adhesins. In Toxoplasma gondii, the conoid, composed of a...
ORGANISM(S): Toxoplasma gondii GT1 
2023-08-31 | PXD031816 | Pride
Apicomplexa Conoid extrusion Egress Motility Alphafold F-actin Invasion Toxoplasma gondii Hdx-ms Plasmodium berghei Preconoidal rings Micronemes 
MetabolomicsPantothenate biosynthesis is critical for chronic infection by the neurotropic parasite Toxoplasma gondii
Coenzyme A (CoA) is an essential molecule acting in metabolism, post-translational modification, and regulation of gene expression. While all organisms synthesize CoA, many, including humans, are unable to produce its precursor, pantothenate. Intriguingly, like most plants, fungi and bacteria, paras...
2022-03-21 | MTBLS2501 | MetaboLights
ProteomicsIdentification of RON13 binding with with RON4 substrate
Active host cell invasion by the obligate intracellular apicomplexan parasites relies on the formation of a moving junction (MJ), which joins parasite and host cell plasma membranes during entry. Invading Toxoplasma gondii tachyzoites secrete a complex of RON proteins from the rhoptry organelles tha...
ORGANISM(S): Toxoplasma gondii GT1 
2021-05-10 | PXD023791 | Pride
Ron13 Toxoplasma gondii Secretory pathway Hdx-ms Kinase 
ProteomicsStructural and regulatory insights into the glideosome-associated connector from Toxoplasma gondii
The phylum of Apicomplexa groups intracellular parasites that employ substrate-dependent gliding motility to invade host cells, egress from the infected cells and cross biological barriers. The glideosome associated connector (GAC) is a conserved protein essential to this process. GAC facilitates th...
ORGANISM(S): Toxoplasma gondii RH-88 
2023-05-10 | PXD039335 | Pride
Apicomplexa Gliding motility X-ray crystallography Hdx-ms Toxoplasma gondii 
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