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ProteomicsNative State Stabilization is an Effective Strategy to Inhibit TDP-43 Oligomerization and Fibrillogenesis
Transactive response DNA-binding protein 43 kDa (TDP-43) is a partially disordered nuclear protein that plays essential roles in RNA metabolism to maintain cellular homeostasis. In individuals with neurodegenerative diseases (NDDs), including Amyotrophic lateral Sclerosis (ALS), Alzheimer’s disease,...
ORGANISM(S): Homo sapiens (Human) Bacteria 
2026-06-24 | PXD041160 | Pride
Hdx-ms Aggregation Neuronal toxicity Oligonucleotides Tar dna binding protein (tdp-43) 
ProteomicsAutoregulation of tubulin mRNA via reversible TTC5 sequestration by soluble ab-tubulins
Microtubule cytoskeleton, built from heterodimers of α and β-tubulins, is critically important to physically organize cells, mediate intracellular transport and power cell division. The availability of soluble αβ-tubulins influences the biomechanical properties and functions of microtubules. When pr...
ORGANISM(S): Homo sapiens (Human) 
2024-10-18 | PXD050483 | Pride
Microtubules Ttc5 Hdx-ms Mrna Tubulin 
ProteomicsConoid extrusion serves as gatekeeper for entry of glideosome components into the pellicular space to control motility and invasion in Apicomplexa
Members of the apicomplexans are defined by apical cytoskeletal structures and secretory or-ganelles, tailored for motility and invasion. Gliding is powered by the actomyosin-dependent rearward translocation of apically secreted transmembrane adhesins. In Toxoplasma gondii, the conoid, composed of a...
ORGANISM(S): Toxoplasma gondii GT1 
2023-08-31 | PXD031816 | Pride
Apicomplexa Conoid extrusion Egress Motility Alphafold F-actin Invasion Toxoplasma gondii Hdx-ms Plasmodium berghei Preconoidal rings Micronemes 
ProteomicsAn inhibitory segment within G-patch activators tunes Prp43-ATPase activity during ribosome assembly
Mechanisms by which G-patch activators tune the processive multi-tasking ATP-dependent RNA helicase Prp43 to remodel diverse RNA:protein complexes remain elusive. Here, a comparative study between a new activator, Tma23, and a characterized activator, Pxr1, uncovered segments that organize Prp43 fun...
ORGANISM(S): Saccharomyces cerevisiae Saccharomyces cerevisiae (Baker's yeast) 
2024-10-09 | PXD046892 | Pride
Ribosome assembly Prp43 Cryo-em Hdx-ms Rna helicase 
ProteomicsInactivation of Influenza A virus under expiratory aerosol conditions is mediated by structural protein changes, as determined by whole virus mass-spectrometry.
Multiple respiratory viruses including Influenza A virus (IAV) can be transmitted via expiratory aerosol particles, and many studies have established that environmental conditions can affect viral infectivity during airborne transmission. Low aerosol pH was recently identified as a major factor infl...
ORGANISM(S): Influenza A virus (A/WSN/1933(H1N1)) 
2023-08-10 | PXD037176 | Pride
Influenza Heamaggluttinin Ph Hdx-ms Hatrix protein 1 
MetabolomicsPantothenate biosynthesis is critical for chronic infection by the neurotropic parasite Toxoplasma gondii
Coenzyme A (CoA) is an essential molecule acting in metabolism, post-translational modification, and regulation of gene expression. While all organisms synthesize CoA, many, including humans, are unable to produce its precursor, pantothenate. Intriguingly, like most plants, fungi and bacteria, paras...
2022-03-21 | MTBLS2501 | MetaboLights
ProteomicsIdentification of RON13 binding with with RON4 substrate
Active host cell invasion by the obligate intracellular apicomplexan parasites relies on the formation of a moving junction (MJ), which joins parasite and host cell plasma membranes during entry. Invading Toxoplasma gondii tachyzoites secrete a complex of RON proteins from the rhoptry organelles tha...
ORGANISM(S): Toxoplasma gondii GT1 
2021-05-10 | PXD023791 | Pride
Ron13 Toxoplasma gondii Secretory pathway Hdx-ms Kinase 
ProteomicsStructural and regulatory insights into the glideosome-associated connector from Toxoplasma gondii
The phylum of Apicomplexa groups intracellular parasites that employ substrate-dependent gliding motility to invade host cells, egress from the infected cells and cross biological barriers. The glideosome associated connector (GAC) is a conserved protein essential to this process. GAC facilitates th...
ORGANISM(S): Toxoplasma gondii RH-88 
2023-05-10 | PXD039335 | Pride
Apicomplexa Gliding motility X-ray crystallography Hdx-ms Toxoplasma gondii 
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