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TranscriptomicsSchistosoma mansoni developmental stages
Transcriptional profiling using two subsequent developmental stages of Schistosoma mansoni (Egg vs. Miracidium; Cercaria vs. 7-days-old Schistosomulum; 7-days-old Schistosomulum vs. Adult worms Two conditions experiment; Developmental Stage 1 vs. Developmental Stage 2
ORGANISM(S): Schistosoma mansoni 
2011-04-30 | E-GEOD-27026 | biostudies-arrayexpress
TranscriptomicsEffect of human TNF-alpha on schistosomulum stage of Schistosoma mansoni gene expression profile
Schistosoma mansoni is the major causative agent of schistosomiasis in the Americas. This parasite takes advantage from host signaling molecules such as cytokines and hormones to complete its development inside the host. TNF-α is the most important cytokine involved in the inflammatory response whe...
ORGANISM(S): Schistosoma mansoni 
2010-06-24 | E-GEOD-16260 | biostudies-arrayexpress
TranscriptomicsEffect of human TNF-alpha on adult Schistosoma mansoni gene expression profile
Schistosoma mansoni is the major causative agent of schistosomiasis in the Americas. This parasite takes advantage from host signaling molecules such as cytokines and hormones to complete its development inside the host. TNF-α is the most important cytokine involved in the inflammatory response whe...
ORGANISM(S): Schistosoma mansoni 
2010-06-24 | E-GEOD-16261 | biostudies-arrayexpress
TranscriptomicsInterference of hemozoin formation in Schistosoma mansoni by quinine reduces experimental schistosomiasis
Background: The parasitic trematode Schistosoma mansoni is one of the major causative agents of human schistosomiasis, which afflicts 200 million people worldwide. Praziquantel is still the only drug used for schistosomiasis treatment and reduction in drug efficiency has prompting the search for ne...
ORGANISM(S): Schistosoma mansoni 
2010-06-24 | E-GEOD-14751 | biostudies-arrayexpress
ProteomicsInhibition of histone methyltransferase EZH2 in Schistosoma mansoni by GSK343 decreases the expression of genes implicated in DNA replication and ncRNA metabolism
Schistosomiasis is a chronic and debilitating disease caused by a trematode of the genus Schistosoma. The current strategy for the control of the disease involves treatment with Praziquantel, the only available drug. The development of new drugs is therefore a top priority. Drugs that inhibit histon...
ORGANISM(S): Schistosoma mansoni (Blood fluke) 
2018-11-23 | PXD010342 | Pride
Proteomics Schistosoma mansoni Ezh2 Gsk343 Rna-seq 
TranscriptomicsConserved tissue expression signatures of intronic noncoding RNAs transcribed from human and mouse loci
It has been postulated that noncoding RNAs (ncRNAs) are involved in the post-transcriptional control of gene expression, and may have contributed to the emergence of the complex attributes observed in mammalians. The complement of ncRNAs expressed from intronic regions of the human and mouse genomes...
ORGANISM(S): Mus musculus 
2008-06-01 | E-GEOD-9950 | biostudies-arrayexpress
TranscriptomicsSm29 is a protective surface protein from the tegument of lung-stage Schistosoma mansoni
Schistosomiasis continues to be a significant public health problem1. Although vaccine development against this disease has experienced more failures than successes, encouraging results have recently been obtained using membrane-spanning protein antigens from the tegument of S. mansoni. Our group re...
ORGANISM(S): Schistosoma mansoni 
2010-05-15 | E-GEOD-10777 | biostudies-arrayexpress
TranscriptomicsGene expression patterns in Schistosoma mansoni larvae and eggs
Protein variation in blood-dwelling schistosome worms generated by differential splicing of micro-exon gene transcripts. The infective schistosome cercaria develops from an undifferentiated germ ball within the daughter sporocyst in the molluscan host, during which considerable morphological develo...
ORGANISM(S): Schistosoma mansoni 
2010-05-29 | E-GEOD-22037 | biostudies-arrayexpress
TranscriptomicsGene expression profile of mesenchymal stem cells from paired umbilical cord units: cord is different from blood
Mesenchymal stem cells (MSC) are multipotent cells which can be obtained from several adult and fetal tissues including human umbilical cord units. We have recently shown that umbilical cord tissue (UC) is richer in MSC than umbilical cord blood (UCB) but their origin and characteristics in blood a...
ORGANISM(S): Homo sapiens 
2009-09-18 | E-GEOD-18134 | biostudies-arrayexpress
TranscriptomicsRNA expression profiles in CD34+ and in stromal cells of patients with refractory anemia with ringed sideroblasts
Myelodysplastic syndromes (MDS) are a group of clonal hematological disorders characterized by ineffective hematopoiesis with morphological evidence of marrow cell dysplasia resulting in peripheral blood cytopenia. Microarray technology has permitted a refined high-throughput mapping of the transcri...
ORGANISM(S): Homo sapiens 
2010-06-22 | E-GEOD-18911 | biostudies-arrayexpress
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