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ProteomicsDifferentially represented proteins in response to tuberculosis identified by quantitative serum proteomics in Asian elephants
The study reported here is the first characterization of elephant serum proteome in response to TB. These results advance our understanding of elephant immune response to M. tuberculosis and provide potential biomarkers for diagnosis and control of TB in this endangered species.
ORGANISM(S): Elephas maximus maximus 
2022-10-15 | PXD033830 | Pride
Elephant  tuberculosis  proteomics  vaccinomics 
ProteomicsMetabolic pathways affected by Anaplasma in tick cells
Anaplasma phagocytophilum is an emerging zoonotic pathogen that causes human granulocytic anaplasmosis. These intracellular bacteria establish infection by affecting cell function in both the vertebrate host and the tick vector, Ixodes scapularis. Previous studies have characterized the tick transcr...
ORGANISM(S): Ixodes scapularis (Black-legged tick) (Deer tick) 
2015-10-05 | PXD002181 | Pride
Ixodes scapularis ise6 cells Anaplasma phagocytophilum Rp-lc-lit-ms 
ProteomicsComparative proteomics identifies host immune system proteins affected by infection with Mycobacterium bovis
Mycobacteria of the Mycobacterium tuberculosis complex (MTBC) greatly impact on human and animal health worldwide. Mycobacterial life cycle is complex and the mechanisms resulting in pathogen infection and survival in host cells are not fully understood. Eurasian wild boar (Sus scrofa) are natural r...
ORGANISM(S): Sus scrofa (Pig) 
2016-03-10 | PXD003251 | Pride
Immune system Wild boar Lc-ms/ms 
ProteomicsPaleoproteomics characterization of fossil holobiont in acari-host-parasite interactions
Paleoproteomics approaches the study of proteins by proteomics analysis in fossil samples. Recently, a protocol was developed and validated for paleoproteomics characterization of fossil arthropod parasitiformes in amber inclusions. In this study, the paleoproteomics approach was applied to arthropo...
ORGANISM(S): fossil metagenome 
2026-03-23 | PXD064361 | Pride
Amber  bird  arachnid  fossil  mite  paleoproteomics  parasitic nematode 
ProteomicsThe Akirin2 regulome and interactome reveal gene/protein targets, candidate functional complements and role in epigenetic regulation
The Akirin (AKR) family of transcription cofactors are involved in the regulation of different biological processes such as immunity, interdigital regression, muscle and neural development throughout the metazoan. This model regulatory proteins do not have catalytic or DNA-binding capability and exe...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022073 | Pride
Regulome Akirin2 Knockdown Interactome Hl60 
ProteomicsSerum proteomics covid-19 vaccine
In the last two years, the coronavirus disease 19 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a scientific and social challenge worldwide. Vaccines have been the most effective intervention for reducing virus transmission and disease severity. ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD031969 | Pride
Covid-19  proteomic  vaccine  immunology  biomarker 
ProteomicsSerum quantitative proteomics identifies prognostic biomarkers and physiological processes related to COVID-19 symptomatology
The coronavirus disease 19 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) posts a challenge for the understanding of factors affecting disease severity and the identification of prognostic biomarkers and physiological processes relevant for the development...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD024549 | Pride
Swath-ms Human serum Covid-19 
ProteomicsRole of complement system pathways in protective immune response to treatment with heat-inactivated Mycobacterium bovis
Development of vaccines to preserve and improve human and animal health require effective protective antigens, delivery platforms and adjuvants. The immunostimulant adjuvant based on heat-inactivated Mycobacterium bovis (IV) was developed to boost protective immune response in different animal speci...
ORGANISM(S): Bos taurus (Bovine) 
2025-10-15 | PXD050002 | Pride
Complement  immunology  proteomic  tuberculosis  vaccine  wild boar 
ProteomicsPaleoproteomics characterization of fossil arthropod parasitiformes amber inclusions
In this study, we developed and applied a paleoproteomics approach to study inclusions of fossil arthropod parasitiformes in two Burmese amber (Cretaceous, ca. 124 - 99 mya) pieces. The results supported the identification of Cornupalpatum sp. and the first report of fossil Holothyrida, Neothyridae ...
ORGANISM(S): Holothyrida 
2025-11-06 | PXD055542 | Pride
Amber  arthropod  fossil  paleontology  paleoproteomics 
ProteomicsPaleoproteomics in fossil amber arthropods
Paleoproteomics is the proteomics analysis of ancient proteins, which may be better preserved than DNA in fossil inclusions and particularly in amber fossilized tree resin. However, only yeast proteins have been previously suggested as identified by paleoproteomics analysis conducted in fossil amber...
ORGANISM(S): fossil metagenome 
2026-03-23 | PXD066794 | Pride
Amber  arthropod  evolution  fossil  paleontology  paleoproteomics 
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