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MetabolomicsAttenuate host susceptibility to respiratory virus invasion by inhibiting interactions between host proteins SLC16A3 and AP1G1

Modulating cell endocytosis activity to reduce host susceptibility to virus represents a promising strategy for antiviral drug development. In this study, we reveal that lactate transporter SLC16A3 as a critical host factor for reducing diverse virus invasion. By performing metabolomics, proteomi...

2025-07-28 | MTBLS12788 | MetaboLights
MetabolomicsViral-Induced Heme Accumulation Subverts TLR4bb-Mediated Antiviral Immunity by Triggering Gut Microbiota Dysbiosis, Metabolic Dysregulation, and Ferroptosis

This study identifies grass carp TLR4bb as a crucial hub coordinating antiviral immunity with heme metabolism, redox balance, and gut microbiota during GCRV-II infection. While TLR4bb recruits TIRAP/MyD88/TRIF to activate IFN signaling against the virus, its synergy with heme and viral sensing tr...

2026-01-23 | MTBLS13755 | MetaboLights
MetabolomicsBacillus subtilis inhibits African swine fever virus infection in vivo and in vitro based on its metabolites arctiin and genistein interfering with the function of viral topoisomerase II

African swine fever virus (ASFV) is an infectious disease with a mortality rate of nearly 100% in pigs; however, no safe commercial vaccines or antiviral drugs are currently available, which seriously threatens the global pig industry. Therefore, effective biologicals against ASFV are urgently ne...

2023-11-01 | MTBLS6586 | MetaboLights
ProteomicsTARA Oceans Viral Proteins - Illuminating structural proteins in viral "dark matter" with metaproteomics
A grand challenge in biology is the lack of annotation for much of global sequence space. In particular, while microbes and their viruses are critical to Earth System functioning, surveys of their communities in nature routinely return genes of unknown function, particularly for viruses. This hamper...
ORGANISM(S): environmental samples 
2016-02-25 | PXD000938 | Pride
Viral proteomics Virus Tara Viral Proteomics Proteins 
ProteomicsConfirmation of plant viral proteins and identification of specific viral strains by nanoLC-ESI-Q-TOF using single-leaf-tissue samples
An efficient protein extraction protocol without any precipitation steps was applied to plant samples from ten economically important plant hosts. Viral proteins from fourteen important viruses (WDV, BYDV/BYDV-PAV, BMV, TAV, CaMV, TMV, TVCV, PPV, TuMV, BCMV, SrMV, SCMV, TRSV, BBWV-2) from seven diff...
ORGANISM(S): Zea mays (Maize) Prunus domestica Brassica rapa subsp. pekinensis Triticum aestivum (Wheat) Hordeum vulgare (Barley) Nicotiana tabacum (Common tobacco) Sorghum bicolor Phaseolus vulgaris (Kidney bean) (French bean) Prunus armeniaca Chenopodium giganteum 
2020-11-20 | PXD022456 | Pride
Tumv Srmv Bmv Camv Wdv Tav Bcmv Trsv Lc-msms Scmv Tmv Bydv/bydv-pav Bbwv-2 Plant Ppv Viral proteins Tvcv 
TranscriptomicsTranscriptional perturbations caused by tumor virus proteins
Genotypic differences greatly influence susceptibility and resistance to disease. Understanding genotype-phenotype relationships requires that phenotypes be viewed as manifestations of network properties, rather than simply as the result of individual genomic variations. Genome sequencing efforts ha...
ORGANISM(S): Homo sapiens 
2012-07-19 | E-GEOD-38467 | biostudies-arrayexpress
TranscriptomicsDifferentially-expressed miRNAs in MDBK cells infected with bovine viral diarrhea virus compared to MDBK cells
Non-canonical microRNAs (miRNAs) are a class of short endogenous RNA molecules with the ability to control development, autophagy, apoptosis and the stress response in eukaryotes by pairing with partially complementary sites in the 3' untranslated regions (UTRs) of targeted genes. Recent studies hav...
ORGANISM(S): Bos taurus 
2014-12-16 | E-GEOD-61251 | biostudies-arrayexpress
ProteomicsSwapped genetic code block viral infections and gene transfer
Removing cellular transfer RNAs (tRNAs), making their cognate codons unreadable, creates a genetic firewall that prevents viral replication and horizontal gene transfer. However, numerous viruses and mobile genetic elements encode parts of the translational apparatus, including tRNAs, potentially re...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2022-07-08 | MSV000089854 | MassIVE
TranscriptomicsRoles and Programming of Arabidopsis ARGONAUTE Proteins During Turnip Mosaic Virus Infection
AGO protein immunoprecipitation was combined with high-throughput sequencing of associated small RNAs. AGO2, AGO10, and to a lesser extent AGO1 were shown to associate with siRNAs derived from silencing suppressor (HC-Pro)-deficient TuMV-AS9, but not with siRNAs derived from wild-type TuMV. Co-immun...
ORGANISM(S): Arabidopsis thaliana 
2015-04-06 | E-GEOD-64911 | biostudies-arrayexpress
ProteomicsMetaproteomics of viral concentrates at deep chlorophyll maximum of Scouth China Sea
Marine viral concentrates (VCs) contains a substantial amount of non-cellular biological particles, e.g. viruses, gene transfer agents (GTAs) and membrane vesicles that are ecological significant. Metagenomic sequencing of VCs has been extensively applied to study the diversity and function potentia...
ORGANISM(S): environmental samples <unclassified> 
2018-05-02 | PXD007174 | Pride
Virua 56 kda selenium-binding protein Viral concentrates Metaproteomics 
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