Sort   by:  
 Page size 
ProteomicsMechanism of ORMDL proteins turnover via proteasome and autophagy is cell-type dependent and tied to ceramide homeostasis
ORMDL proteins are essential negative regulators of the serine palmitoyltransferase (SPT) complex, thereby controlling the rate of de novo sphingolipid synthesis. Although mammalian ORMDL proteins undergo rapid turnover, the mechanisms regulating their stability are not completely understood, with c...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD067431 | Pride
Autophagy Sphingolipid Lc3 Fumonisin b1 Proteasome degradation Ormdl3 Myriocin 
ProteomicsPhosphorylation of TRF2 promotes its interaction with TIN2 and regulates DNA repair at damaged telomeres.
Protein phosphatase magnesium-dependent 1 delta (PPM1D) terminates the cell cycle checkpoint by dephosphorylating the tumour suppressor protein p53. By targeting additional substrates at chromatin, PPM1D contributes to the control of DNA damage response and DNA repair. Using proximity biotinylation ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035273 | Pride
Trf2 Shelterin Telomere Phosphorylation Ppm1d phosphatase 
ProteomicsHypolipidemic effects of beetroot juice in SHR-CRP and HHTg rat models of metabolic syndrome: Analysis of hepatic proteome.
Recently, red beetroot has attracted attention as a health promoting functional food. Studies showed that beetroot administration can reduce blood pressure and ameliorate parameters of glucose and lipid metabolism, however, mechanisms underlying these beneficial effects of beetroot are not fully und...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-03-11 | PXD039605 | Pride
Mtor signaling Spontaneously hypertensive rat Lipids Glycerophospholipid metabolism Beetroot Hereditary hypertriglyceridemic rat 
ProteomicsSpontaneous nonsense mutation in Tuft1 (tuftelin 1) gene is associated with abnormal hair appearance and amelioration of glucose and lipid metabolism in the rat
A new spontaneous mutation, abnormal hair appearance in the rat, has been identified as a non-functional Tuft1 (tuftelin 1) gene. The pleiotropic effects of this mutation regulate glucose and lipid metabolism. Analysis of the liver proteome revealed possible molecular mechanisms for the metabolic ef...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-03-12 | PXD045880 | Pride
Hepatic proteome  lipid and glucose metabolism  rat  spontaneous nonsense mutation  tuft1 (tuftelin 1) gene 
ProteomicsPhysiological variability in mitochondrial rRNA may predispose to metabolic syndrome
Objectives: Metabolic syndrome and its associated comorbidities are a growing concern in developed societies. Due to its polygenic nature, the genetic component of metabolic syndrome is only slowly being elucidated. Common mitochondrial DNA sequence variants have been associated with late-onset huma...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-08-13 | PXD045910 | Pride
Metabolic syndrome  mitochondrial haplotype  diacylglycerols  insulin signaling 
ProteomicsMitochondrial translation is the primary determinant of secondary mitochondrial complex I deficiencies
Individual complexes of the mitochondrial oxidative phosphorylation system (OXPHOS) are not linked solely by their function, they also share dependencies at the maintenance/assembly level, where one complex depends on the presence of a different individual complex. Despite the relevance of this ‘i...
ORGANISM(S): Homo sapiens (Human) 
2024-07-16 | PXD046331 | Pride
Integrated stress response Mitochondria Oxphos Complex i Mitochondrial protein synthesis Secondary deficiency Complex iv Complex v Mitochondrial translation Biogenesis interdependency 
ProteomicsCOX6B1 secures a redox-sensitive step in early cytochrome c oxidase assembly
COX6B is one of the eleven nuclear-encoded subunits of the human mitochondrial inner-membrane cytochrome c oxidase (cIV), which is located in the intermembrane space-facing region of cIV. In mammals, there are two COX6B isoforms: the ubiquitous isoform COX6B1, expressed in all cell types and tissues...
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD061621 | Pride
Mitochondria Alternative oxidase (aox) Cytochrome c oxidase Respiratory chain biogenesis 
ProteomicsHaplotype variability in mitochondrial rRNA predisposes to metabolic syndrome
Metabolic syndrome is a growing concern in developed societies and due to its polygenic nature, the genetic component is only slowly being elucidated. Common mitochondrial DNA sequence variants have been associated with symptoms of metabolic syndrome and may therefore be relevant players in the gene...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-08-13 | PXD052976 | Pride
Metabolic syndrome Diacylglycerols Mitochondrial haplotype Insulin signaling 
ProteomicsLoss of COX4i1 leads to combined respiratory chain deficiency and impaired mitochondrial protein synthesis
The oxidative phosphorylation (OXPHOS) system localized in the inner mitochondrial membrane secures production of the majority of ATP in mammalian organisms. Individual OXPHOS complexes form supramolecular assemblies termed supercomplexes. The complexes are linked not only by their function but also...
ORGANISM(S): Homo sapiens (Human) 
2021-02-18 | PXD023367 | Pride
Knock-out Cox Mitochondria Oxphos Complex i Cox assembly Mitochondrial protein synthesis Cox4 Biogenesis interdependency Complexome profiling 
ProteomicsCOX6B1 secures a redox-sensitive step in early cytochrome c oxidase assembly
COX6B is one of the eleven nuclear-encoded subunits of the human mitochondrial inner-membrane cytochrome c oxidase (cIV), which is located in the intermembrane space-facing region of cIV. In mammals, there are two COX6B isoforms: the ubiquitous isoform COX6B1, expressed in all cell types and tissues...
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD061618 | Pride
Mitochondria Alternative oxidase (aox) Cytochrome c oxidase Respiratory chain biogenesis Complexome profiling 
Sort   by:  
 Page size