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UnknownAnatomically modern human in Southeast Asia (Laos) by 46 ka.
Not available
S-EPMC3437904 | biostudies-literature
ProteomicsThe CDK12-inhibitor CR8 mediates Cyclin K degradation through the CUL4-RBX1-DDB1 E3 ubiquitin ligase
Small molecules have been identified that induce protein-protein interactions between a substrate and a ubiquitin ligase, resulting in targeted protein degradation. Such molecular glue compounds, unlike traditional enzyme inhibitors, act sub-stoichiometrically to catalyse rapid depletion of previous...
ORGANISM(S): Homo sapiens (Human) 
2020-06-10 | PXD016188 | Pride
Cr8 Cyclin k Molecular glue Cdk12 Ubiquitin Crl4ddb1 
ProteomicsThe CDK12-inhibitor CR8 mediates Cyclin K degradation through the CUL4-RBX1-DDB1 E3 ubiquitin ligase
Small molecules have been identified that induce protein-protein interactions between a substrate and a ubiquitin ligase, resulting in targeted protein degradation. Such molecular glue compounds, unlike traditional enzyme inhibitors, act sub-stoichiometrically to catalyse rapid depletion of previous...
ORGANISM(S): Homo sapiens (Human) 
2020-06-10 | PXD016187 | Pride
Crl4 Cr8 Cyclin k Molecular glue Cdk12 Ubiquitin Ddb1 
TranscriptomicsLudwig Institute/UCSD ENCODE project June 2007 Release
The readout of genome information is controlled by transcriptional regulatory elements, but a comprehensive view of the combinatorial control by these DNA sequences, which bind regulatory protein and/or the modified histones in regulating gene transcription, is clearly preliminary. We have developed...
ORGANISM(S): Homo sapiens 
2007-06-01 | E-GEOD-7872 | biostudies-arrayexpress
UnknownPlatelet-Rich Plasma for Treating Chronic Noncancer Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Not available
S-EPMC12279671 | biostudies-literature
ProteomicsAdipocyte FMO3-derived TMAO induces WAT dysfunction and metabolic disorders by promoting inflammasome activation in ageing
Circulating trimethylamine N-oxide (TMAO) participates in the pathogenesis of cardio-metabolic diseases, with hepatic flavin-containing monooxygenase 3 (FMO3) originally regarded as the primary source of TMAO production. Here, we demonstrate that white adipose tissue (WAT) expressed FMO3 and its der...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-23 | PXD066391 | Pride
Macrophage Mouse Inflammasome Adipocyte Fmo3 Tmao 
UnknownAssociation Between Dietary Vitamin K Intake With Cancer Cachexia and Mortality: NHANES 1999-2018.
Not available
S-EPMC12566881 | biostudies-literature
UnknownPredicting the Risk of Lumbar Prolapsed Disc: A Gene Signature-Based Machine Learning Analysis.
Not available
S-EPMC12085505 | biostudies-literature
ProteomicsMiddle-Late Pleistocene Denisovans and unresolved Homo in southern China
Shotgun palaeoproteomic analyses were conducted on three teeth from two cave sites (Chuanshandong and Longchuandong) in Guangxi, southern China, dated to >100.8 ka and 104.5-42.6 ka, respectively. Typical enamel proteome was recovered. SAP assignment and phylogenetic analyses suggested that the Long...
ORGANISM(S): Homo sapiens (Human) 
2026-10-16 | PXD071210 | Pride
Enamel Lc ms/ms Archaic human 
TranscriptomicsShoot tip tissue: Tall Mokka vs Typica.
The closely related Coffea arabica cultivars ‘Tall Mokka’ and ‘Typica’, with excellent flavor, but differing distinctively in the size of aerial organs, branching pattern and branch numbers. Differential gene expression analysis of shoot tips of arabica coffee cultivars 'Tall Mokka' and 'Typica' wer...
ORGANISM(S): Coffea arabica 
2011-08-03 | E-GEOD-31179 | biostudies-arrayexpress
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