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ProteomicsMulti-omics analyses reveal that HIV-1 alters CD4 T cell immunometabolism to fuel virus replication
Human Immunodeficiency Virus type-1 (HIV-1)-infected individuals show metabolic alterations of CD4 T cells through unclear mechanisms with undefined consequences. We analyzed the transcriptome of CD4 T cells from HIV-1 patients and revealed that elevated oxidative phosphorylation (OXPHOS) pathway i...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD023565 | Pride
Hiv-1 Cd4 t cell Virus replication Nlrx1 Fastkd5 Oxidative phosphorylation 
ProteomicsG9a/GLP inhibition during ex vivo lymphocyte expansion increases in vivo cytotoxicity of engineered TCR-T cells against hepatocellular carcinoma
Engineered T cells transiently expressing tumor-targeting receptors are an attractive form of engineered T cell therapy as they carry no risk of insertional mutagenesis or long-term adverse side-effects. However, multiple rounds of treatment are often required, increasing patient discomfort and cost...
ORGANISM(S): Homo Sapiens (human) 
2023-01-19 | PXD039542 | JPOST Repository
UnknownAssociation of colorectal cancer susceptibility variants with esophageal cancer in a Chinese population.
Not available
S-EPMC4462730 | biostudies-literature
UnknownA Mendelian randomization study investigating the causal associations of 35 blood and urinary metabolite biomarkers with breast cancer development.
Not available
S-EPMC12048380 | biostudies-literature
UnknownWilson disease with hepatic presentation in an eight-month-old boy.
Not available
S-EPMC4528042 | biostudies-literature
UnknownTwo novel VPS33B mutations in a patient with arthrogryposis, renal dysfunction and cholestasis syndrome in mainland China.
Not available
S-EPMC3886028 | biostudies-literature
UnknownInterface Engineering of Fe7S8/FeS2 Heterostructure in situ Encapsulated into Nitrogen-Doped Carbon Nanotubes for High Power Sodium-Ion Batteries.
Not available
S-EPMC10149539 | biostudies-literature
UnknownRAGE gene three polymorphisms with Crohn's disease susceptibility in Chinese Han population.
Not available
S-EPMC3942844 | biostudies-literature
UnknownAngiopterisnodosipetiolata (Marattiaceae), a new fern species from Yunnan, China.
Not available
S-EPMC11077261 | biostudies-literature
ProteomicsAIM2 in regulatory T (Treg) cells restrains autoimmune diseases
The inflammasome initiates innate defense and inflammatory response by activating caspase-1 and pyroptotic cell death in myeloid cells1,2. It is comprised of an innate immune receptor/effector, pro-caspase-1 and a common adaptor molecule, ASC (apoptotic speck-containing protein with a CARD). Consis...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-27 | PXD018638 | Pride
Autoimmunity Aim2 (absent in melanoma 2) Akt-mtor signaling 
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