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ProteomicsDeep Phosphoproteomic Elucidation of Metformin-Signaling in Heterogenous Colorectal Cancer Cells
The biguanide drug metformin is a safe and widely prescribed drug for type 2 diabetes. Interestingly, hundreds of clinical trials were set to evaluate the potential role of metformin in the prevention and treatment of cancer including colorectal cancer (CRC). However, the metformin-induced cell sign...
ORGANISM(S): Homo sapiens (Human) 
2023-02-18 | PXD036826 | Pride
Dia-ms Phosphoproteomics Metformin Colorectal cancer 
ProteomicsQuantitative phosphoproteomics for nocodazole treated cells measured by Lumos DIA
Phosphoproteomic DIA-MS quantitative dataset for nocodazole treated cells (or “PhosDIA” in short). The MS samples injected in a previous publication for developing the IPF, an algorithm for identifying post-translationally modified peptides, were herein re-measured by a new, powerful Orbitrap Lumos ...
ORGANISM(S): Homo sapiens (Human) 
2020-06-08 | PXD017476 | Pride
Phosphoproteomics U2os cells Dia Nocodazle Lumos Cell cycle 
ProteomicsPhosphoproteomic analysis supporting structural basis for GABAA receptor pi activation
GABAA receptors (GABAAR) are pentameric chloride channels comprising various combinations of different subunits that are activated by γ-aminobutyric acid (GABA), the main inhibitory neurotransmitter in vertebrates. we show here that GABRP chloride channel activity and ERK signaling is directly regul...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD044482 | Pride
Phosphoproteomics Dia Gabaa receptor 
ProteomicsProteomic and phosphoproteomic profilings in fibroblasts of 11 common mammalian species
A central goal of modern biology is to understand the molecular basis of phenotype evolution between species. Previously, the evolutionary profiling at the molecular level has been largely limited to the nucleotide level. Nevertheless, the genotype is translated to proteotype through comprehensive a...
ORGANISM(S): Bos taurus (Bovine) Sus scrofa (Pig) Homo sapiens (Human) Oryctolagus cuniculus (Rabbit) Canis lupus Monodelphis domestica Felis catus (Cat) (Felis silvestris catus) Rattus norvegicus (Rat) Ovis aries Macaca mulatta (Rhesus macaque) Equus caballus (Horse) 
2022-09-22 | PXD028979 | Pride
Phosphoproteomics Dia-ms Multiple species Quantitative proteomics 
ProteomicsProteomic analysis of the physiological E3 ubiquitin ligase responsible for PIN1 degradation
Induced oncoproteins degradation provides an attractive anti-cancer modality. Activation of anaphase-promoting complex (APC/CCDH1) prevents cell cycle entry by targeting crucial mitotic proteins for degradation. Phosphorylation of its co-activator CDH1 modulates the E3 ligase activity, but little is...
ORGANISM(S): Homo sapiens (Human) 
2024-02-28 | PXD046325 | Pride
Pin1 Proteomics Cdh1 
ProteomicsProteomics analysis of blood neutrophils from WT and Wnt5 DKO mice under DSS treatment
Neutrophils are abundant innate immune cells with important roles in host defense and many inflammatory diseases. They possess plasticity and heterogenicity, which underlie their functional ambivalency; they can be beneficial or detrimental to host well-being depending on contexts. While bone marrow...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-16 | PXD048613 | Pride
Wnt5 Neutrophil Proteomics Dia 
ProteomicsProteomics analysis of expi293 conditioned media purified with immobilized metal affinity chromatography
Isthmin-1 (ISM1) is a recently described adipokine with insulin-like properties, reported to regulate hyperglycemia and liver steatosis. However, contrary to earlier studies, we demonstrate that highly purified ISM1 does not stimulate AKT phosphorylation in 3T3-F442A pre-adipocytes. Instead, this ac...
ORGANISM(S): Homo sapiens (Human) 
2025-04-02 | PXD062353 | Pride
Dia Proteomics Akt 
ProteomicsA Robust Multiplex-DIA Workflow Profiles Protein Turnover Regulations Associated with Cisplatin Resistance and Aneuploidy
Measuring protein turnover is essential for understanding cellular biological processes and advancing drug discovery. The multiplex-DIA mass spectrometry (DIA-MS) approach, combined with dynamic SILAC labeling (pulse-SILAC, or pSILAC), has proven to be a reliable method for analyzing protein turnove...
ORGANISM(S): Homo sapiens (Human) 
2025-05-14 | PXD057632 | Pride
Aneuploidy Quantitative proteomics Protein turnover Dia Drug resistance Multiplex-dia Pulse silac 
ProteomicsFibroblast-derived Smoothened governs prognosis of acute kidney injury
Although the tubule is the epicenter of damage, kidney fibroblast is increasingly appreciated in governing the prognosis of acute kidney injury (AKI). Smoothened (Smo), a heptahelical transmembrane protein, carries a hedgehog signal to mediate the communications between kidney fibroblasts and tubula...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-12-23 | MSV000088609 | MassIVE
ProteomicsHOTAIR knockdown glioma cell proteomics
This study demonstrated the effects of lncRNA HOTAIR knockdown on the glioma proteomics. An abnormally high expression of the lncRNA HOTAIR has been previously demonstrated in glioma cells. HOTAIR regulates genes by anchoring epigenetic modification proteins and causes abnormalities in multiple sign...
ORGANISM(S): Homo Sapiens 
2021-12-31 | PXD029919 |
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