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MetabolomicsMolecular networking coupled to high-resolution mass spectrometry fragmentation reveals a multitude of urinary antihypertensive drug metabolites
Mass spectrometry is the current technique of choice in studying drug metabolism. High-resolution mass spectrometry (HR-MS) in combination with fragment analysis (MS/MS) has the potential to contribute to rapid advances in this field. However, the data emerging from such fragmentation spectra pose c...
2016-05-23 | MTBLS307 | MetaboLights
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
MetabolomicsLipidFrag: Improving reliability of in silico fragmentation of lipids and application to the Caenorhabditis elegans lipidome
Lipid identification is a major bottleneck in high-throughput lipidomics studies. We combined the in silico fragmentation tool MetFrag with LipidMaps lipid-class specific classifiers which calculate probabilities for lipid class assignments. The LipidFrag approach was then applied to MS/MS spectra o...
2017-03-09 | MTBLS291 | MetaboLights
ProteomicsSCAI orchestrates DNA interstrand crosslink repair downstream of FANCI-FANCD2 ubiquitylation (total proteome)
By covalently linking Watson and Crick strands, DNA interstrand crosslinks (ICLs) are highly toxic lesions that block DNA replication and threaten genome integrity. The Fanconi anemia (FA) pathway orchestrates ICL repair during DNA replication, with ubiquitylated FANCI-FANCD2 (ID2) marking the activ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-02-18 | PXD029409 | Pride
Scai Xenopus Total proteome Interstrand crosslink repair Npe Dna damage Icl Fanci Fancd2 
ProteomicsSCAI orchestrates DNA interstrand crosslink repair downstream of FANCI-FANCD2 ubiquitylation
By covalently linking Watson and Crick strands, DNA interstrand crosslinks (ICLs) are highly toxic lesions that block DNA replication and threaten genome integrity. The Fanconi anemia (FA) pathway orchestrates ICL repair during DNA replication, with ubiquitylated FANCI-FANCD2 (ID2) marking the activ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-02-18 | PXD024280 | Pride
Scai Xenopus Interstrand crosslink repair Chromass Dna damage Icl Fanci Fancd2 
ProteomicsCavia porcellus spectral library
The guinea pig (cavia porcellus) is an excellent experimental model for translation to many aspects of human physiology and disease yet there is limited experimental information regarding its proteome. In an effort to overcome this gap in our knowledge, we generated a comprehensive spectral library ...
ORGANISM(S): Cavia Porcellus (ncbitaxon:10141) 
2018-12-07 | MSV000083199 | MassIVE
TranscriptomicsCharacterisation of the mouse megakaryocyte transcriptome
This study aims to identify all genes expressed in primary mouse megakaryocytes Keywords: Megakaryocyte, SAGE, transcriptome analysis Mouse megakaryocytes were grown in vitro from bone marrow progenitors. Mature, polyploid (approximately 95% 64n and 128n) differentiated megakaryocytes were used to ...
ORGANISM(S): Mus musculus 
2007-02-02 | E-GEOD-6940 | biostudies-arrayexpress
MetabolomicsA conserved metabolic signature associated with response to fast-acting antimalarial agents

Characterizing the mode of action of antimalarial compounds that emerge from high-throughput phenotypic screens is central to understanding how parasite resistance to these drugs can emerge. Here, we have employed untargeted metabolomics to inform on the mechanism of action of antimalarial leads ...

2023-09-27 | MTBLS6580 | MetaboLights
ProteomicsMass spectrometry detection of photodamage in human extracellular matrix assemblies
Photoageing in skin is commonly recognised by architectural remodelling of dermal extracellular matrix components. Mass spectrometry was previously used to identify tissue-specific patterns of fibrillin-1 and collagen VI peptide spectrum matches (PXD008450). This study aimed to determine if the same...
ORGANISM(S): Homo sapiens (Human) 
2020-01-30 | PXD015149 | Pride
Human Ecm Collagen vi Fibrillin Ultraviolet Microfibrils Lc-ms/ms 
ProteomicsNovel skin photoageing biomarkers of epidermis and dermis revealed by traditional relative quantification in combination with a novel peptide locational fingerprinting MPLF.
Human skin undergoes profound structural remodelling following chronic exposure to ultraviolet radiation (UVR) – photoageing - that is normally studied by comparing photoexposed and photoprotected skin sites. Whilst it is well established that the abundance and distribution of major dermal extracell...
ORGANISM(S): Homo sapiens (Human) 
2021-04-09 | PXD021194 | Pride
#skin #epidermis #dermis #biomarkers 
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