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UnknownA greener, efficient approach to Michael addition of barbituric acid to nitroalkene in aqueous diethylamine medium.
Not available
S-EPMC6271361 | biostudies-literature
TranscriptomicsGene Expression underlying Osteo-, Adipo-, and Chondro-Genic Lineage Commitment of Human Mesenchymal Stem Cells
Chondrogenic differentiation of hMSC has been investigated by this study using different growth conditions including control (INC), TGFβ1 (T), TGFβ1 + BMP2 (TB), TGFβ1 + GDF5 (TG). For each condition triplicate time course expression measurements were performed for 10 different time points. Osteoge...
ORGANISM(S): Homo sapiens 
2015-07-15 | E-MTAB-3731 | biostudies-arrayexpress
MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
GenomicsDNA binding factors shape the mouse methylome at distal regulatory regions [ChIP-seq].
To gain insights into the interplay between DNA methylation and gene regulation we generated a basepair resolution reference map of the mouse methylome in stem cells and neurons. High genome coverage allowed for a novel quantitative analysis of local methylation states, which identified Low Methylat...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-30203 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of retinae from wildtype and retinoschisin knockout mice (Rs1h-/Y) at postnatal day 7 to understand the effect of retinoschisin on gene expression
Genome-wide expression profiling of the retinoschisin deficient retina in C57CL/6 mice. Experiment Overall Design: RNAs from retinae from 3 Wildtype Mice versus 3 Retinoschisin-KO mice (Rs1h-/Y) at postnatal day 7 (P7) were hybridized onto Affymetrix microarrays.
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-5581 | biostudies-arrayexpress
GenomicsComparative epigenomic analysis of JUN, H3K27ac, H3K4me3 and H3K4me2 in primary aortic endothelial cells
This accession ID containes ChIP-seq data for JUN, H3K27ac, H3K4me3 and H3K4me2 in primary aortic endothelial cells. This data will be used for: 1) A phylogenetic framework for comparative analysis of chromatin state in mammalian species. Sara Knaack, Lina Antounians, Azad Alizada, Alejandra Medina...
ORGANISM(S): Rattus norvegicus 
2025-06-19 | E-MTAB-14612 | biostudies-arrayexpress
TranscriptomicsNatural variation in human gene expression assessed in lymphoblastoid cells
Lymphoblastoid cells from 35 unrelated individuals used to examined variation in gene expression. Identified genes whose transcript levels differed greatly among unrelated individuals.
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-137 | biostudies-arrayexpress
GenomicsA comparative epigenomics approach reveals REST as a mediator of Polycomb reprogramming during neuronal differentiation
Transcription factors (TFs) in concert with chromatin pathways stably reset transcriptional programs during differentiation. Yet we know little how local sites of chromatin reprogramming are specified and how the estimated 3000 TF encoded in mammalian genomes contribute to chromatin dynamics. To ide...
ORGANISM(S): Mus musculus 
2012-09-04 | E-GEOD-27148 | biostudies-arrayexpress
UnknownExperimental and Computational Investigations of the Reactions between α,β-Unsaturated Lactones and 1,3-Dienes by Cooperative Lewis Acid/Bronsted Acid Catalysis.
Not available
S-EPMC7589441 | biostudies-literature
TranscriptomicsThe activation of IL-1-induced enhancers depends on TAK1 kinase activity and NF-kappaB p65 I
The inflammatory gene response requires activation of the protein kinase TAK1, but it is currently unknown how TAK1-derived signals coordinate transcriptional programs in the genome. We determined the genome-wide binding of the TAK1-controlled NF-M-NM-:B subunit p65 in relation to active enhancers a...
ORGANISM(S): Homo sapiens 
2014-12-17 | E-GEOD-64201 | biostudies-arrayexpress
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