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UnknownA greener, efficient approach to Michael addition of barbituric acid to nitroalkene in aqueous diethylamine medium.
Not available
S-EPMC6271361 | biostudies-literature
TranscriptomicsGene Expression underlying Osteo-, Adipo-, and Chondro-Genic Lineage Commitment of Human Mesenchymal Stem Cells
Chondrogenic differentiation of hMSC has been investigated by this study using different growth conditions including control (INC), TGFβ1 (T), TGFβ1 + BMP2 (TB), TGFβ1 + GDF5 (TG). For each condition triplicate time course expression measurements were performed for 10 different time points. Osteoge...
ORGANISM(S): Homo sapiens 
2015-07-15 | E-MTAB-3731 | biostudies-arrayexpress
MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
GenomicsDNA binding factors shape the mouse methylome at distal regulatory regions [ChIP-seq].
To gain insights into the interplay between DNA methylation and gene regulation we generated a basepair resolution reference map of the mouse methylome in stem cells and neurons. High genome coverage allowed for a novel quantitative analysis of local methylation states, which identified Low Methylat...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-30203 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of retinae from wildtype and retinoschisin knockout mice (Rs1h-/Y) at postnatal day 7 to understand the effect of retinoschisin on gene expression
Genome-wide expression profiling of the retinoschisin deficient retina in C57CL/6 mice. Experiment Overall Design: RNAs from retinae from 3 Wildtype Mice versus 3 Retinoschisin-KO mice (Rs1h-/Y) at postnatal day 7 (P7) were hybridized onto Affymetrix microarrays.
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-5581 | biostudies-arrayexpress
ProteomicsE2F6 initiates stable epigenetic silencing of germline genes during embryonic development
In mouse development, long-term silencing by CpG island DNA methylation is specifically targeted to germline genes, however the molecular mechanisms of this specificity remain unclear. Here we demonstrate that the transcription factor E2F6, a member of the polycomb repressive complex 1.6 (PRC1.6), i...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-22 | PXD023974 | Pride
Embryonic stem cells Prc1.6 Dna methylation E2f6 
GenomicsComparative epigenomic analysis of JUN, H3K27ac, H3K4me3 and H3K4me2 in primary aortic endothelial cells
This accession ID containes ChIP-seq data for JUN, H3K27ac, H3K4me3 and H3K4me2 in primary aortic endothelial cells. This data will be used for: 1) A phylogenetic framework for comparative analysis of chromatin state in mammalian species. Sara Knaack, Lina Antounians, Azad Alizada, Alejandra Medina...
ORGANISM(S): Rattus norvegicus 
2025-06-19 | E-MTAB-14612 | biostudies-arrayexpress
ProteomicsSystematic identification of factors involved in the silencing of germline genes in mouse embryonic stem cells
In mammals, many germline genes are repressed by epigenetic mechanisms to prevent their illegitimate expression in embryonic and somatic cells. To advance our understanding of the complete mechanisms restricting the expression of germline genes in mammals, we analyzed the chromatin signature of germ...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-03 | PXD030666 | Pride
Germline genes Erh Prc1.6 Shfm1 Crispr-cas9 screen Dna methylation Es cells Usp7 
ProteomicsDynamic proximity based interactome of the transcription factor RELA to identify gene-regulatory networks revealed
Using p65-miniTurbo fusion proteins in HeLa cells, we identified by biotin tagging > 350 RELA interactors from untreated and IL-1a-stimulated cells, including many TFs (47 % of all interactors) and > 50 epigenetic regulators belonging to different classes of chromatin remodeling complexes.
ORGANISM(S): Homo sapiens (Human) 
2024-11-04 | PXD045888 | Pride
Lc-msms Rela Affinity proteomics Turbo id Genetic networks P65 nf-kb Interactome 
TranscriptomicsNatural variation in human gene expression assessed in lymphoblastoid cells
Lymphoblastoid cells from 35 unrelated individuals used to examined variation in gene expression. Identified genes whose transcript levels differed greatly among unrelated individuals.
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-137 | biostudies-arrayexpress
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